Vitamin D Deficiency among HIV Type 1-Infected Individuals in the Netherlands : Effects of Antiretroviral Therapy

Vitamin D regulates bone metabolism but has also immunoregulatory properties. In HIV-infected patients bone disorders are increasingly observed. Furthermore, low 1,25(OH)(2)D(3) levels have been associated with low CD4(+) counts, immunological hyperactivity, and AIDS progression rates. Few studies h...

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Veröffentlicht in:	AIDS research and human retroviruses 2008-11, Vol.24 (11), p.1375-1382
Hauptverfasser:	VAN DEN BOUT-VAN DEN BEUKEL, Carolien J. P, FIEVEZ, Lydia, MICHELS, Meta, SWEEP, Fred C. G. J, HERMUS, Ad R. M. M, BOSCH, Marjolein E. W, BURGER, David M, BRAVENBOER, Bert, KOOPMANS, Peter P, VAN DER VEN, André J. A. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiretroviral Therapy, Highly Active - adverse effects Antiviral agents Biological and medical sciences Care and treatment CD4 Lymphocyte Count Complications and side effects Demographic aspects Dosage and administration Drug therapy Female Fundamental and applied biological sciences. Psychology HIV infection HIV Infections - complications HIV Infections - drug therapy HIV Infections - immunology HIV-1 - isolation & purification Human immunodeficiency virus Human viral diseases Humans Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Netherlands Parathyroid Hormone - blood Prevalence Retrovirus Risk Factors Skin Pigmentation Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology Vitamin D deficiency Vitamin D Deficiency - chemically induced
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Zusammenfassung:	Vitamin D regulates bone metabolism but has also immunoregulatory properties. In HIV-infected patients bone disorders are increasingly observed. Furthermore, low 1,25(OH)(2)D(3) levels have been associated with low CD4(+) counts, immunological hyperactivity, and AIDS progression rates. Few studies have examined the vitamin D status in HIV-infected patients. This study will specifically focus on the effects of antiretroviral agents on vitamin D status. Furthermore, the effect of vitamin D status on CD4 cell recovery after initiation of HAART will be evaluated. Among 252 included patients the prevalence of vitamin D deficiency (
ISSN:	0889-2229 1931-8405
DOI:	10.1089/aid.2008.0058