The respiratory chain complex thresholds in mitochondria of a Drosophila subobscura mutant strain

Analysis of a mutant strain of Drosophila subobscura revealed that most (80%) mitochondrial genomes have undergone a large scale deletion (5 kb) in the coding region. Compared with the wild-type strain, complex I and III activities are, respectively, reduced by 50% and 30% in the mutant. However, th...

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Veröffentlicht in:	Biochimie 2002-12, Vol.84 (12), p.1189-1197
Hauptverfasser:	Farge, G., Touraille, S., Debise, R., Alziari, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - biosynthesis Animals Antimycin A - analogs & derivatives Antimycin A - pharmacology ATP synthesis Citrate (si)-Synthase - antagonists & inhibitors Citrate (si)-Synthase - metabolism Dose-Response Relationship, Drug Drosophila - genetics Drosophila - metabolism Drosophila subobscura Electron Transport - physiology Electron Transport Complex I - metabolism Electron Transport Complex III - antagonists & inhibitors Electron Transport Complex III - metabolism Electron Transport Complex IV - antagonists & inhibitors Electron Transport Complex IV - metabolism Enzyme Inhibitors - pharmacology Female Glycerophosphates - metabolism Heteroplasmy Kinetics Male Mitochondria - drug effects Mitochondria - enzymology Multienzyme Complexes - metabolism Mutation NADH, NADPH Oxidoreductases - antagonists & inhibitors NADH, NADPH Oxidoreductases - metabolism Oxidation-Reduction - drug effects Oxygen Consumption Potassium Cyanide - pharmacology Respiratory chain complexes Rotenone - pharmacology Threshold curves
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