Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi-lysosome contact site

In response to amino acid supply, mTORC1, a master regulator of cell growth, is recruited to the lysosome and activated by the small GTPase Rheb. However, the intracellular localization of Rheb is controversial. In this study, we showed that a significant portion of Rheb is localized on the Golgi bu...

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Veröffentlicht in:	Journal of cell science 2018-02, Vol.131 (3), p.jcs208017-jcs208017
Hauptverfasser:	Hao, Feike, Kondo, Kazuhiko, Itoh, Takashi, Ikari, Sumiko, Nada, Shigeyuki, Okada, Masato, Noda, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Activation Amino acids Golgi apparatus Guanosine triphosphatases Localization
Online-Zugang:	Volltext
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