The toxin BjussuLAAO-II induces oxidative stress and DNA damage, upregulates the inflammatory cytokine genes TNF and IL6, and downregulates the apoptotic-related genes BAX, BCL2 and RELA in human Caco-2 cells

•BjussuLAAO-II is a snake venom toxin with cytotoxic effects towards Caco-2 cells.•The toxin induces necrosis, apoptosis, oxidative stress, and DNA damage.•The toxin reduces cell viability by acting on multiple intracellular targets.•The toxin upregulates the inflammatory cytokine genes TNF and IL6...

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Veröffentlicht in:	International journal of biological macromolecules 2018-04, Vol.109, p.212-219
Hauptverfasser:	Machado, A.R.T., Aissa, A.F, Ribeiro, D.L., Hernandes, L.C., Machado, C.S., Bianchi, M.L.P., Sampaio, S.V., Antunes, L.M.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Comet assay Gene expression L-amino acid oxidase Snake venom
Online-Zugang:	Volltext
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