Variable transcriptional responsiveness of the P2X3 receptor gene during CFA‐induced inflammatory hyperalgesia

The purinergic receptor P2X3 (P2X3‐R) plays important roles in molecular pathways of pain, and reduction of its activity or expression effectively reduces chronic inflammatory and neuropathic pain sensation. Inflammation, nerve injury, and cancer‐induced pain can increase P2X3‐R mRNA and/or protein...

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Veröffentlicht in:	Journal of cellular biochemistry 2018-05, Vol.119 (5), p.3922-3935
Hauptverfasser:	Nuñez‐Badinez, Paulina, Sepúlveda, Hugo, Diaz, Emilio, Greffrath, Wolfgang, Treede, Rolf‐Detlef, Stehberg, Jimmy, Montecino, Martin, van Zundert, Brigitte
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Cancer Chromatin Core Binding Factor Alpha 2 Subunit - metabolism Dorsal root ganglia DRG epigenetic modifications Epigenetics Freund's adjuvant Freund's Adjuvant - adverse effects Freund's Adjuvant - pharmacology Ganglia Ganglia, Spinal - metabolism Ganglia, Spinal - pathology Gene Expression Regulation - drug effects Histone H3 Hyperalgesia Hyperalgesia - chemically induced Hyperalgesia - metabolism Hyperalgesia - pathology Immunoprecipitation Inflammation Injury prevention Male Molecular modelling Neuralgia Neurons P2X3‐R Pain Pain perception Rats Rats, Sprague-Dawley Receptors, Purinergic P2X3 - biosynthesis Regulators Rodents Runx1 Runx1 protein Transcription, Genetic - drug effects
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