Clinical outcome of cardioembolic stroke treated by intravenous thrombolysis

Introduction Cardioembolic stroke (CS) in patients without thrombolytic treatment is associated with a worse clinical outcome and higher mortality compared to other types of stroke. The aim of this study was to determine the clinical outcome of CS in patients treated by intravenous thrombolysis (IVT...

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Veröffentlicht in:Acta neurologica Scandinavica 2018-03, Vol.137 (3), p.347-355
Hauptverfasser: Vaclavik, D., Vilionskis, A., Jatuzis, D., Karlinski, M. A., Gdovinova, Z., Kõrv, J., Tsivgoulis, G., Mikulik, R.
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container_end_page 355
container_issue 3
container_start_page 347
container_title Acta neurologica Scandinavica
container_volume 137
creator Vaclavik, D.
Vilionskis, A.
Jatuzis, D.
Karlinski, M. A.
Gdovinova, Z.
Kõrv, J.
Tsivgoulis, G.
Mikulik, R.
description Introduction Cardioembolic stroke (CS) in patients without thrombolytic treatment is associated with a worse clinical outcome and higher mortality compared to other types of stroke. The aim of this study was to determine the clinical outcome of CS in patients treated by intravenous thrombolysis (IVT). Material and methodology Data of patients from the SITS‐EAST register (Safe Implementation of Treatments in Stroke) were analyzed in patients who received IVT treatment from 2000 to April 2014. The effect of the stroke etiology according to ICD‐10 classification on outcome was analyzed using a univariate and multivariate analysis. The outcomes were assessed as follows: excellent clinical outcome (modified Rankin scale (mRS) 0‐1) at 3 months, the rate of symptomatic intracranial hemorrhage (sICH), mortality, and improvement at 24 hours after IVT. Results Data of 13 772 patients were analyzed. CS represented 30% of all strokes. The mean age of patients with CS, atherothrombotic stroke, lacunar stroke, and other stroke was 70.8, 66.7, 66.2, and 63.3 years, respectively (P 
doi_str_mv 10.1111/ane.12880
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A. ; Gdovinova, Z. ; Kõrv, J. ; Tsivgoulis, G. ; Mikulik, R.</creator><creatorcontrib>Vaclavik, D. ; Vilionskis, A. ; Jatuzis, D. ; Karlinski, M. A. ; Gdovinova, Z. ; Kõrv, J. ; Tsivgoulis, G. ; Mikulik, R.</creatorcontrib><description>Introduction Cardioembolic stroke (CS) in patients without thrombolytic treatment is associated with a worse clinical outcome and higher mortality compared to other types of stroke. The aim of this study was to determine the clinical outcome of CS in patients treated by intravenous thrombolysis (IVT). Material and methodology Data of patients from the SITS‐EAST register (Safe Implementation of Treatments in Stroke) were analyzed in patients who received IVT treatment from 2000 to April 2014. The effect of the stroke etiology according to ICD‐10 classification on outcome was analyzed using a univariate and multivariate analysis. The outcomes were assessed as follows: excellent clinical outcome (modified Rankin scale (mRS) 0‐1) at 3 months, the rate of symptomatic intracranial hemorrhage (sICH), mortality, and improvement at 24 hours after IVT. Results Data of 13 772 patients were analyzed. CS represented 30% of all strokes. The mean age of patients with CS, atherothrombotic stroke, lacunar stroke, and other stroke was 70.8, 66.7, 66.2, and 63.3 years, respectively (P &lt; .001). Severity of stroke on admission by median NIHSS score was 13 points in patients with CS, 12 points – in atherothrombotic stroke, 7 points – in lacunar stroke, and 10 points—in other stroke types (P &lt; .001). No difference in mortality was detected among atherothrombotic and CS; however, atherothrombotic strokes had higher odds of sICH [OR = 1.63 (95% CI: 1.07‐2.47), P = .023], lower odds of early improvement [OR = 0.79 (95% CI: 0.72‐0.86), P &lt; .001], and excellent clinical outcome [OR = 0.77 (95% CI: 0.67‐0.87), P &lt; .001] compared with CS. Conclusions Cardioembolic strokes are not associated with increased mortality. Patients with CS are less likely to have sICH and have better outcome after IVT.</description><identifier>ISSN: 0001-6314</identifier><identifier>EISSN: 1600-0404</identifier><identifier>DOI: 10.1111/ane.12880</identifier><identifier>PMID: 29218699</identifier><language>eng</language><publisher>Denmark: Hindawi Limited</publisher><subject>cardioembolic stroke ; Clinical outcomes ; Etiology ; Hemorrhage ; Intravenous administration ; Mortality ; Multivariate analysis ; outcome ; SITS register ; Stroke ; Thrombolysis</subject><ispartof>Acta neurologica Scandinavica, 2018-03, Vol.137 (3), p.347-355</ispartof><rights>2017 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd</rights><rights>2017 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd.</rights><rights>Copyright © 2018 John Wiley &amp; Sons A/S. 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A.</creatorcontrib><creatorcontrib>Gdovinova, Z.</creatorcontrib><creatorcontrib>Kõrv, J.</creatorcontrib><creatorcontrib>Tsivgoulis, G.</creatorcontrib><creatorcontrib>Mikulik, R.</creatorcontrib><title>Clinical outcome of cardioembolic stroke treated by intravenous thrombolysis</title><title>Acta neurologica Scandinavica</title><addtitle>Acta Neurol Scand</addtitle><description>Introduction Cardioembolic stroke (CS) in patients without thrombolytic treatment is associated with a worse clinical outcome and higher mortality compared to other types of stroke. The aim of this study was to determine the clinical outcome of CS in patients treated by intravenous thrombolysis (IVT). Material and methodology Data of patients from the SITS‐EAST register (Safe Implementation of Treatments in Stroke) were analyzed in patients who received IVT treatment from 2000 to April 2014. The effect of the stroke etiology according to ICD‐10 classification on outcome was analyzed using a univariate and multivariate analysis. The outcomes were assessed as follows: excellent clinical outcome (modified Rankin scale (mRS) 0‐1) at 3 months, the rate of symptomatic intracranial hemorrhage (sICH), mortality, and improvement at 24 hours after IVT. Results Data of 13 772 patients were analyzed. CS represented 30% of all strokes. The mean age of patients with CS, atherothrombotic stroke, lacunar stroke, and other stroke was 70.8, 66.7, 66.2, and 63.3 years, respectively (P &lt; .001). Severity of stroke on admission by median NIHSS score was 13 points in patients with CS, 12 points – in atherothrombotic stroke, 7 points – in lacunar stroke, and 10 points—in other stroke types (P &lt; .001). No difference in mortality was detected among atherothrombotic and CS; however, atherothrombotic strokes had higher odds of sICH [OR = 1.63 (95% CI: 1.07‐2.47), P = .023], lower odds of early improvement [OR = 0.79 (95% CI: 0.72‐0.86), P &lt; .001], and excellent clinical outcome [OR = 0.77 (95% CI: 0.67‐0.87), P &lt; .001] compared with CS. Conclusions Cardioembolic strokes are not associated with increased mortality. Patients with CS are less likely to have sICH and have better outcome after IVT.</description><subject>cardioembolic stroke</subject><subject>Clinical outcomes</subject><subject>Etiology</subject><subject>Hemorrhage</subject><subject>Intravenous administration</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>outcome</subject><subject>SITS register</subject><subject>Stroke</subject><subject>Thrombolysis</subject><issn>0001-6314</issn><issn>1600-0404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp10M1LwzAYBvAgipvTg_-ABLzooVu--pGjjPkBQy96Dmn7FjPbZiat0v_ezE4Pgrm8BH48PDwInVMyp-EtdAtzyrKMHKApTQiJiCDiEE0JITRKOBUTdOL9JvxYKsQxmjDJaJZIOUXrZW1aU-ga274rbAPYVrjQrjQWmtzWpsC-c_YNcOdAd1DifMCm7Zz-gNb2Hnevzu7g4I0_RUeVrj2c7e8Mvdyunpf30frp7mF5s44KHkpGtEgklJVMBK-qpMoBZE60jAmLNQehuQaqiUhKIQSXGjJWypTpBCQvqaCUz9DVmLt19r0H36nG-ALqOgwROikq05jQVKZpoJd_6Mb2rg3tgpKcxTRlcVDXoyqc9d5BpbbONNoNihK1m1iFZPU9cbAX-8Q-b6D8lT-bBrAYwaepYfg_Sd08rsbIL2Z6hSE</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Vaclavik, D.</creator><creator>Vilionskis, A.</creator><creator>Jatuzis, D.</creator><creator>Karlinski, M. A.</creator><creator>Gdovinova, Z.</creator><creator>Kõrv, J.</creator><creator>Tsivgoulis, G.</creator><creator>Mikulik, R.</creator><general>Hindawi Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6728-2020</orcidid><orcidid>https://orcid.org/0000-0002-1902-1093</orcidid></search><sort><creationdate>201803</creationdate><title>Clinical outcome of cardioembolic stroke treated by intravenous thrombolysis</title><author>Vaclavik, D. ; Vilionskis, A. ; Jatuzis, D. ; Karlinski, M. A. ; Gdovinova, Z. ; Kõrv, J. ; Tsivgoulis, G. ; Mikulik, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3880-1c69edf9643ff6fbee9b0a95025a3e4a3ae1a046d44439ae82d972a6e93d14113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>cardioembolic stroke</topic><topic>Clinical outcomes</topic><topic>Etiology</topic><topic>Hemorrhage</topic><topic>Intravenous administration</topic><topic>Mortality</topic><topic>Multivariate analysis</topic><topic>outcome</topic><topic>SITS register</topic><topic>Stroke</topic><topic>Thrombolysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vaclavik, D.</creatorcontrib><creatorcontrib>Vilionskis, A.</creatorcontrib><creatorcontrib>Jatuzis, D.</creatorcontrib><creatorcontrib>Karlinski, M. A.</creatorcontrib><creatorcontrib>Gdovinova, Z.</creatorcontrib><creatorcontrib>Kõrv, J.</creatorcontrib><creatorcontrib>Tsivgoulis, G.</creatorcontrib><creatorcontrib>Mikulik, R.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neurologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaclavik, D.</au><au>Vilionskis, A.</au><au>Jatuzis, D.</au><au>Karlinski, M. A.</au><au>Gdovinova, Z.</au><au>Kõrv, J.</au><au>Tsivgoulis, G.</au><au>Mikulik, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical outcome of cardioembolic stroke treated by intravenous thrombolysis</atitle><jtitle>Acta neurologica Scandinavica</jtitle><addtitle>Acta Neurol Scand</addtitle><date>2018-03</date><risdate>2018</risdate><volume>137</volume><issue>3</issue><spage>347</spage><epage>355</epage><pages>347-355</pages><issn>0001-6314</issn><eissn>1600-0404</eissn><abstract>Introduction Cardioembolic stroke (CS) in patients without thrombolytic treatment is associated with a worse clinical outcome and higher mortality compared to other types of stroke. The aim of this study was to determine the clinical outcome of CS in patients treated by intravenous thrombolysis (IVT). Material and methodology Data of patients from the SITS‐EAST register (Safe Implementation of Treatments in Stroke) were analyzed in patients who received IVT treatment from 2000 to April 2014. The effect of the stroke etiology according to ICD‐10 classification on outcome was analyzed using a univariate and multivariate analysis. The outcomes were assessed as follows: excellent clinical outcome (modified Rankin scale (mRS) 0‐1) at 3 months, the rate of symptomatic intracranial hemorrhage (sICH), mortality, and improvement at 24 hours after IVT. Results Data of 13 772 patients were analyzed. CS represented 30% of all strokes. The mean age of patients with CS, atherothrombotic stroke, lacunar stroke, and other stroke was 70.8, 66.7, 66.2, and 63.3 years, respectively (P &lt; .001). Severity of stroke on admission by median NIHSS score was 13 points in patients with CS, 12 points – in atherothrombotic stroke, 7 points – in lacunar stroke, and 10 points—in other stroke types (P &lt; .001). No difference in mortality was detected among atherothrombotic and CS; however, atherothrombotic strokes had higher odds of sICH [OR = 1.63 (95% CI: 1.07‐2.47), P = .023], lower odds of early improvement [OR = 0.79 (95% CI: 0.72‐0.86), P &lt; .001], and excellent clinical outcome [OR = 0.77 (95% CI: 0.67‐0.87), P &lt; .001] compared with CS. Conclusions Cardioembolic strokes are not associated with increased mortality. Patients with CS are less likely to have sICH and have better outcome after IVT.</abstract><cop>Denmark</cop><pub>Hindawi Limited</pub><pmid>29218699</pmid><doi>10.1111/ane.12880</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6728-2020</orcidid><orcidid>https://orcid.org/0000-0002-1902-1093</orcidid><oa>free_for_read</oa></addata></record>
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subjects cardioembolic stroke
Clinical outcomes
Etiology
Hemorrhage
Intravenous administration
Mortality
Multivariate analysis
outcome
SITS register
Stroke
Thrombolysis
title Clinical outcome of cardioembolic stroke treated by intravenous thrombolysis
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