Regulation of floral meristem activity through the interaction of AGAMOUS, SUPERMAN, and CLAVATA3 in Arabidopsis
Key message Floral meristem size is redundantly controlled by CLAVATA3 , AGAMOUS , and SUPERMAN in Arabidopsis . The proper regulation of floral meristem activity is key to the formation of optimally sized flowers with a fixed number of organs. In Arabidopsis thaliana , multiple regulators determine...
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| Veröffentlicht in: | Plant reproduction 2018-03, Vol.31 (1), p.89-105 |
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| container_title | Plant reproduction |
| container_volume | 31 |
| creator | Uemura, Akira Yamaguchi, Nobutoshi Xu, Yifeng Wee, WanYi Ichihashi, Yasunori Suzuki, Takamasa Shibata, Arisa Shirasu, Ken Ito, Toshiro |
| description | Key message
Floral meristem size is redundantly controlled by
CLAVATA3
,
AGAMOUS
, and
SUPERMAN
in
Arabidopsis
.
The proper regulation of floral meristem activity is key to the formation of optimally sized flowers with a fixed number of organs. In
Arabidopsis thaliana
, multiple regulators determine this activity. A small secreted peptide, CLAVATA3 (CLV3), functions as an important negative regulator of stem cell activity. Two transcription factors, AGAMOUS (AG) and SUPERMAN (SUP), act in different pathways to regulate the termination of floral meristem activity. Previous research has not addressed the genetic interactions among these three genes. Here, we quantified the floral developmental stage-specific phenotypic consequences of combining mutations of
AG, SUP,
and
CLV3
. Our detailed phenotypic and genetic analyses revealed that these three genes act in partially redundant pathways to coordinately modulate floral meristem sizes in a spatial and temporal manner. Analyses of the
ag sup clv3
triple mutant, which developed a mass of undifferentiated cells in its flowers, allowed us to identify downstream targets of AG with roles in reproductive development and in the termination of floral meristem activity. Our study highlights the role of AG in repressing genes that are expressed in organ initial cells to control floral meristem activity. |
| doi_str_mv | 10.1007/s00497-017-0315-0 |
| format | Article |
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Floral meristem size is redundantly controlled by
CLAVATA3
,
AGAMOUS
, and
SUPERMAN
in
Arabidopsis
.
The proper regulation of floral meristem activity is key to the formation of optimally sized flowers with a fixed number of organs. In
Arabidopsis thaliana
, multiple regulators determine this activity. A small secreted peptide, CLAVATA3 (CLV3), functions as an important negative regulator of stem cell activity. Two transcription factors, AGAMOUS (AG) and SUPERMAN (SUP), act in different pathways to regulate the termination of floral meristem activity. Previous research has not addressed the genetic interactions among these three genes. Here, we quantified the floral developmental stage-specific phenotypic consequences of combining mutations of
AG, SUP,
and
CLV3
. Our detailed phenotypic and genetic analyses revealed that these three genes act in partially redundant pathways to coordinately modulate floral meristem sizes in a spatial and temporal manner. Analyses of the
ag sup clv3
triple mutant, which developed a mass of undifferentiated cells in its flowers, allowed us to identify downstream targets of AG with roles in reproductive development and in the termination of floral meristem activity. Our study highlights the role of AG in repressing genes that are expressed in organ initial cells to control floral meristem activity.</description><identifier>ISSN: 2194-7953</identifier><identifier>EISSN: 2194-7961</identifier><identifier>DOI: 10.1007/s00497-017-0315-0</identifier><identifier>PMID: 29218596</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>AGAMOUS Protein, Arabidopsis - genetics ; AGAMOUS Protein, Arabidopsis - physiology ; Agriculture ; Arabidopsis - genetics ; Arabidopsis - physiology ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - physiology ; Arabidopsis thaliana ; Biomedical and Life Sciences ; Cell Biology ; Control ; Developmental stages ; DNA binding proteins ; Flowers ; Flowers - genetics ; Flowers - growth & development ; Flowers - physiology ; Gene Expression Regulation, Plant ; Genes ; Genetic analysis ; Life Sciences ; Meristem - physiology ; Mutation ; Organs ; Original Article ; Plant Cells - physiology ; Plant Reproduction Research in Asia ; Plant Sciences ; Regulators ; Reproduction ; Spatial analysis ; Stem cells ; Target recognition ; Transcription factors ; Transcription Factors - genetics ; Transcription Factors - physiology</subject><ispartof>Plant reproduction, 2018-03, Vol.31 (1), p.89-105</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2017</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-109411593a57aaaefbaccec15cd47e449b44c8f29836c1c74d7552035c20a9093</citedby><cites>FETCH-LOGICAL-c511t-109411593a57aaaefbaccec15cd47e449b44c8f29836c1c74d7552035c20a9093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00497-017-0315-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00497-017-0315-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29218596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uemura, Akira</creatorcontrib><creatorcontrib>Yamaguchi, Nobutoshi</creatorcontrib><creatorcontrib>Xu, Yifeng</creatorcontrib><creatorcontrib>Wee, WanYi</creatorcontrib><creatorcontrib>Ichihashi, Yasunori</creatorcontrib><creatorcontrib>Suzuki, Takamasa</creatorcontrib><creatorcontrib>Shibata, Arisa</creatorcontrib><creatorcontrib>Shirasu, Ken</creatorcontrib><creatorcontrib>Ito, Toshiro</creatorcontrib><title>Regulation of floral meristem activity through the interaction of AGAMOUS, SUPERMAN, and CLAVATA3 in Arabidopsis</title><title>Plant reproduction</title><addtitle>Plant Reprod</addtitle><addtitle>Plant Reprod</addtitle><description>Key message
Floral meristem size is redundantly controlled by
CLAVATA3
,
AGAMOUS
, and
SUPERMAN
in
Arabidopsis
.
The proper regulation of floral meristem activity is key to the formation of optimally sized flowers with a fixed number of organs. In
Arabidopsis thaliana
, multiple regulators determine this activity. A small secreted peptide, CLAVATA3 (CLV3), functions as an important negative regulator of stem cell activity. Two transcription factors, AGAMOUS (AG) and SUPERMAN (SUP), act in different pathways to regulate the termination of floral meristem activity. Previous research has not addressed the genetic interactions among these three genes. Here, we quantified the floral developmental stage-specific phenotypic consequences of combining mutations of
AG, SUP,
and
CLV3
. Our detailed phenotypic and genetic analyses revealed that these three genes act in partially redundant pathways to coordinately modulate floral meristem sizes in a spatial and temporal manner. Analyses of the
ag sup clv3
triple mutant, which developed a mass of undifferentiated cells in its flowers, allowed us to identify downstream targets of AG with roles in reproductive development and in the termination of floral meristem activity. Our study highlights the role of AG in repressing genes that are expressed in organ initial cells to control floral meristem activity.</description><subject>AGAMOUS Protein, Arabidopsis - genetics</subject><subject>AGAMOUS Protein, Arabidopsis - physiology</subject><subject>Agriculture</subject><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - physiology</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - physiology</subject><subject>Arabidopsis thaliana</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Control</subject><subject>Developmental stages</subject><subject>DNA binding proteins</subject><subject>Flowers</subject><subject>Flowers - genetics</subject><subject>Flowers - growth & development</subject><subject>Flowers - physiology</subject><subject>Gene Expression Regulation, Plant</subject><subject>Genes</subject><subject>Genetic analysis</subject><subject>Life Sciences</subject><subject>Meristem - physiology</subject><subject>Mutation</subject><subject>Organs</subject><subject>Original Article</subject><subject>Plant Cells - physiology</subject><subject>Plant Reproduction Research in Asia</subject><subject>Plant Sciences</subject><subject>Regulators</subject><subject>Reproduction</subject><subject>Spatial analysis</subject><subject>Stem cells</subject><subject>Target recognition</subject><subject>Transcription factors</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - physiology</subject><issn>2194-7953</issn><issn>2194-7961</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFq3DAQhkVpacI2D9BLEfTSQpxqZMm2jmZJ08CmKbvZXoVWlh0F29pKcknePlqcpqRQhDRC8_3DaH6E3gM5A0LKL4EQJsqMQNo58Iy8QscUBMtKUcDr5zvPj9BJCHeEEDhwhL1FR1RQqLgojtF-bbqpV9G6EbsWt73zqseD8TZEM2Clo_1t4wOOt95N3W2KBtsxGn_IzJr6or663m5O8Wb743x9VX8_xWps8HJV_6xv6jzhuPZqZxu3Dza8Q29a1Qdz8hQXaPv1_Gb5LVtdX1wu61WmOUDMgAgGwEWueKmUMu1OaW00cN2w0jAmdozpqqWiygsNumRNyTklOdeUKEFEvkCf5rp7735NJkQ52KBN36vRuClIECVPsxM5JPTjP-idm_yYupOUAC1oVVGWqLOZ6lRvpB1bF9MQ0mrMYLUbTWvTe81zwqrUQJEEn18IEhPNfezUFIK83KxfsjCz2rsQvGnl3ttB-QcJRB7slrPdMrUsDzamY4E-PLU97QbTPCv-mJsAOgMhpcbO-L__-n_VR52FsNQ</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Uemura, Akira</creator><creator>Yamaguchi, Nobutoshi</creator><creator>Xu, Yifeng</creator><creator>Wee, WanYi</creator><creator>Ichihashi, Yasunori</creator><creator>Suzuki, Takamasa</creator><creator>Shibata, Arisa</creator><creator>Shirasu, Ken</creator><creator>Ito, Toshiro</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7X8</scope></search><sort><creationdate>20180301</creationdate><title>Regulation of floral meristem activity through the interaction of AGAMOUS, SUPERMAN, and CLAVATA3 in Arabidopsis</title><author>Uemura, Akira ; Yamaguchi, Nobutoshi ; Xu, Yifeng ; Wee, WanYi ; Ichihashi, Yasunori ; Suzuki, Takamasa ; Shibata, Arisa ; Shirasu, Ken ; Ito, Toshiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-109411593a57aaaefbaccec15cd47e449b44c8f29836c1c74d7552035c20a9093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>AGAMOUS Protein, Arabidopsis - genetics</topic><topic>AGAMOUS Protein, Arabidopsis - physiology</topic><topic>Agriculture</topic><topic>Arabidopsis - genetics</topic><topic>Arabidopsis - physiology</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis Proteins - physiology</topic><topic>Arabidopsis thaliana</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Control</topic><topic>Developmental stages</topic><topic>DNA binding proteins</topic><topic>Flowers</topic><topic>Flowers - genetics</topic><topic>Flowers - growth & development</topic><topic>Flowers - physiology</topic><topic>Gene Expression Regulation, Plant</topic><topic>Genes</topic><topic>Genetic analysis</topic><topic>Life Sciences</topic><topic>Meristem - physiology</topic><topic>Mutation</topic><topic>Organs</topic><topic>Original Article</topic><topic>Plant Cells - physiology</topic><topic>Plant Reproduction Research in Asia</topic><topic>Plant Sciences</topic><topic>Regulators</topic><topic>Reproduction</topic><topic>Spatial analysis</topic><topic>Stem cells</topic><topic>Target recognition</topic><topic>Transcription factors</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uemura, Akira</creatorcontrib><creatorcontrib>Yamaguchi, Nobutoshi</creatorcontrib><creatorcontrib>Xu, Yifeng</creatorcontrib><creatorcontrib>Wee, WanYi</creatorcontrib><creatorcontrib>Ichihashi, Yasunori</creatorcontrib><creatorcontrib>Suzuki, Takamasa</creatorcontrib><creatorcontrib>Shibata, Arisa</creatorcontrib><creatorcontrib>Shirasu, Ken</creatorcontrib><creatorcontrib>Ito, Toshiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><jtitle>Plant reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uemura, Akira</au><au>Yamaguchi, Nobutoshi</au><au>Xu, Yifeng</au><au>Wee, WanYi</au><au>Ichihashi, Yasunori</au><au>Suzuki, Takamasa</au><au>Shibata, Arisa</au><au>Shirasu, Ken</au><au>Ito, Toshiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of floral meristem activity through the interaction of AGAMOUS, SUPERMAN, and CLAVATA3 in Arabidopsis</atitle><jtitle>Plant reproduction</jtitle><stitle>Plant Reprod</stitle><addtitle>Plant Reprod</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>31</volume><issue>1</issue><spage>89</spage><epage>105</epage><pages>89-105</pages><issn>2194-7953</issn><eissn>2194-7961</eissn><abstract>Key message
Floral meristem size is redundantly controlled by
CLAVATA3
,
AGAMOUS
, and
SUPERMAN
in
Arabidopsis
.
The proper regulation of floral meristem activity is key to the formation of optimally sized flowers with a fixed number of organs. In
Arabidopsis thaliana
, multiple regulators determine this activity. A small secreted peptide, CLAVATA3 (CLV3), functions as an important negative regulator of stem cell activity. Two transcription factors, AGAMOUS (AG) and SUPERMAN (SUP), act in different pathways to regulate the termination of floral meristem activity. Previous research has not addressed the genetic interactions among these three genes. Here, we quantified the floral developmental stage-specific phenotypic consequences of combining mutations of
AG, SUP,
and
CLV3
. Our detailed phenotypic and genetic analyses revealed that these three genes act in partially redundant pathways to coordinately modulate floral meristem sizes in a spatial and temporal manner. Analyses of the
ag sup clv3
triple mutant, which developed a mass of undifferentiated cells in its flowers, allowed us to identify downstream targets of AG with roles in reproductive development and in the termination of floral meristem activity. Our study highlights the role of AG in repressing genes that are expressed in organ initial cells to control floral meristem activity.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29218596</pmid><doi>10.1007/s00497-017-0315-0</doi><tpages>17</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2194-7953 |
| ispartof | Plant reproduction, 2018-03, Vol.31 (1), p.89-105 |
| issn | 2194-7953 2194-7961 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1975017931 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | AGAMOUS Protein, Arabidopsis - genetics AGAMOUS Protein, Arabidopsis - physiology Agriculture Arabidopsis - genetics Arabidopsis - physiology Arabidopsis Proteins - genetics Arabidopsis Proteins - physiology Arabidopsis thaliana Biomedical and Life Sciences Cell Biology Control Developmental stages DNA binding proteins Flowers Flowers - genetics Flowers - growth & development Flowers - physiology Gene Expression Regulation, Plant Genes Genetic analysis Life Sciences Meristem - physiology Mutation Organs Original Article Plant Cells - physiology Plant Reproduction Research in Asia Plant Sciences Regulators Reproduction Spatial analysis Stem cells Target recognition Transcription factors Transcription Factors - genetics Transcription Factors - physiology |
| title | Regulation of floral meristem activity through the interaction of AGAMOUS, SUPERMAN, and CLAVATA3 in Arabidopsis |
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