Evaluation of the ability of arsenic species to traverse cell membranes by simple diffusion using octanol-water and liposome-water partition coefficients
Arsenic metabolism in living organisms is dependent on the ability of different arsenic species to traverse biological membranes. Simple diffusion provides an alternative influx and efflux route to mediated transport mechanisms that can increase the amount of arsenic available for metabolism in cell...
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Veröffentlicht in: | Journal of environmental sciences (China) 2016-11, Vol.49 (11), p.222-232 |
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description | Arsenic metabolism in living organisms is dependent on the ability of different arsenic species to traverse biological membranes. Simple diffusion provides an alternative influx and efflux route to mediated transport mechanisms that can increase the amount of arsenic available for metabolism in cells. Using octanol-water and liposome-water partition coefficients, the ability of arsenous acid, arsenate, methylarsonate, dimethylarsinate, thio-methylarsonate, thiodimethylarsinic acid, arsenotriglutathione and monomethylarsonic diglutathione to diffuse through the lipid bilayer of cell membranes was investigated. Molecular modelling of arsenic species was used to explain the results. All arsenic species with the exception of arsenate, methylarsonate and thio-methylarsonate were able to diffuse through the lipid bilayer of liposomes, with liposome-water partition coefficients between 0.04 and 0.13. Trivalent arsenic species and thio-pentavalent arsenic species showed higher partition coefficients, suggesting that they can easily traverse cell membranes by passive simple diffusion. Given the higher toxicity of these species compared to oxo-pentavalent arsenic species, this study provides evidence supporting the risk associated with human exposure to trivalent and thio-arsenic species. |
doi_str_mv | 10.1016/j.jes.2016.08.007 |
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Simple diffusion provides an alternative influx and efflux route to mediated transport mechanisms that can increase the amount of arsenic available for metabolism in cells. Using octanol-water and liposome-water partition coefficients, the ability of arsenous acid, arsenate, methylarsonate, dimethylarsinate, thio-methylarsonate, thiodimethylarsinic acid, arsenotriglutathione and monomethylarsonic diglutathione to diffuse through the lipid bilayer of cell membranes was investigated. Molecular modelling of arsenic species was used to explain the results. All arsenic species with the exception of arsenate, methylarsonate and thio-methylarsonate were able to diffuse through the lipid bilayer of liposomes, with liposome-water partition coefficients between 0.04 and 0.13. Trivalent arsenic species and thio-pentavalent arsenic species showed higher partition coefficients, suggesting that they can easily traverse cell membranes by passive simple diffusion. Given the higher toxicity of these species compared to oxo-pentavalent arsenic species, this study provides evidence supporting the risk associated with human exposure to trivalent and thio-arsenic species.</description><identifier>ISSN: 1001-0742</identifier><identifier>EISSN: 1878-7320</identifier><identifier>DOI: 10.1016/j.jes.2016.08.007</identifier><identifier>PMID: 29216971</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Arsenic ; Liposomes ; Partition coefficients ; Passive simple diffusion ; Thio-arsenic species ; Trivalent arsenic species ; 扩散 ; 氧物种 ; 砷形态 ; 细胞膜 ; 能力评价 ; 脂水分配系数 ; 脂质体 ; 醇-水</subject><ispartof>Journal of environmental sciences (China), 2016-11, Vol.49 (11), p.222-232</ispartof><rights>2016</rights><rights>Copyright © 2016. 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Simple diffusion provides an alternative influx and efflux route to mediated transport mechanisms that can increase the amount of arsenic available for metabolism in cells. Using octanol-water and liposome-water partition coefficients, the ability of arsenous acid, arsenate, methylarsonate, dimethylarsinate, thio-methylarsonate, thiodimethylarsinic acid, arsenotriglutathione and monomethylarsonic diglutathione to diffuse through the lipid bilayer of cell membranes was investigated. Molecular modelling of arsenic species was used to explain the results. All arsenic species with the exception of arsenate, methylarsonate and thio-methylarsonate were able to diffuse through the lipid bilayer of liposomes, with liposome-water partition coefficients between 0.04 and 0.13. Trivalent arsenic species and thio-pentavalent arsenic species showed higher partition coefficients, suggesting that they can easily traverse cell membranes by passive simple diffusion. Given the higher toxicity of these species compared to oxo-pentavalent arsenic species, this study provides evidence supporting the risk associated with human exposure to trivalent and thio-arsenic species.</description><subject>Arsenic</subject><subject>Liposomes</subject><subject>Partition coefficients</subject><subject>Passive simple diffusion</subject><subject>Thio-arsenic species</subject><subject>Trivalent arsenic species</subject><subject>扩散</subject><subject>氧物种</subject><subject>砷形态</subject><subject>细胞膜</subject><subject>能力评价</subject><subject>脂水分配系数</subject><subject>脂质体</subject><subject>醇-水</subject><issn>1001-0742</issn><issn>1878-7320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9UU1v3CAQtapGTZr2B_RSoZ56sTNgDLZ6qqL0Q4qUS3pGGA8JK9s4gDfan9J_W9zd5tgLDMObN_PmFcUHChUFKq521Q5jxXJYQVsByFfFBW1lW8qawescA9ASJGfnxdsYdwDAG2jeFOesY1R0kl4Uv2_2elx1cn4m3pL0iET3bnTpsD11iDg7Q-KCxmEkyZMU9B5zmhgcRzLh1Ac956_-QKKblhHJ4Kxd40aYz_mBeJP07MfyWScMRM8DGd3io5_wlFp0SO7vBMajtS63mlN8V5xZPUZ8f7ovi1_fbu6vf5S3d99_Xn-9LU3dQip7K7DtWYMdBzrwrqHW9D3XINhg-NB3tWiEZgYMsyibznZt20ouDQcu-CDry-LzkXcJ_mnFmNTk4iYuy_JrVLSTDdBGsDpD6RFqgo8xoFVLcJMOB0VBbY6oncqOqM0RBa3KjuSajyf6tZ9weKn4Z0EGfDkCMIvcOwwqbgswOLiAJqnBu__SfzqN9Ojnh6e875cOQlJWM8FZ_QfwiasB</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Chávez-Capilla, Teresa</creator><creator>Maher, William</creator><creator>Kelly, Tamsin</creator><creator>Foster, Simon</creator><general>Elsevier B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W92</scope><scope>~WA</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Evaluation of the ability of arsenic species to traverse cell membranes by simple diffusion using octanol-water and liposome-water partition coefficients</title><author>Chávez-Capilla, Teresa ; Maher, William ; Kelly, Tamsin ; Foster, Simon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-bf6e8b25e9401d4951fcbb4a062dc4db93656a2c0c2fe759f9888747c40464d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Arsenic</topic><topic>Liposomes</topic><topic>Partition coefficients</topic><topic>Passive simple diffusion</topic><topic>Thio-arsenic species</topic><topic>Trivalent arsenic species</topic><topic>扩散</topic><topic>氧物种</topic><topic>砷形态</topic><topic>细胞膜</topic><topic>能力评价</topic><topic>脂水分配系数</topic><topic>脂质体</topic><topic>醇-水</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chávez-Capilla, Teresa</creatorcontrib><creatorcontrib>Maher, William</creatorcontrib><creatorcontrib>Kelly, Tamsin</creatorcontrib><creatorcontrib>Foster, Simon</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-工程技术</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of environmental sciences (China)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chávez-Capilla, Teresa</au><au>Maher, William</au><au>Kelly, Tamsin</au><au>Foster, Simon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the ability of arsenic species to traverse cell membranes by simple diffusion using octanol-water and liposome-water partition coefficients</atitle><jtitle>Journal of environmental sciences (China)</jtitle><addtitle>Journal of Environmental Sciences</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>49</volume><issue>11</issue><spage>222</spage><epage>232</epage><pages>222-232</pages><issn>1001-0742</issn><eissn>1878-7320</eissn><abstract>Arsenic metabolism in living organisms is dependent on the ability of different arsenic species to traverse biological membranes. 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source | Elsevier ScienceDirect Journals; Alma/SFX Local Collection |
subjects | Arsenic Liposomes Partition coefficients Passive simple diffusion Thio-arsenic species Trivalent arsenic species 扩散 氧物种 砷形态 细胞膜 能力评价 脂水分配系数 脂质体 醇-水 |
title | Evaluation of the ability of arsenic species to traverse cell membranes by simple diffusion using octanol-water and liposome-water partition coefficients |
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