No association between SNP309 promoter polymorphism in the MDM2 and cervical cancer in a study from northeastern Brazil

Abstract Background : A functional variant in the MDM2 promoter (a T/G substitution, SNP309) was found to be associated with increased expression of MDM2 gene products and at significantly earlier age onset of tumors in both hereditary Li-Fraumeni individuals and sporadic cancer patients. We tested...

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Veröffentlicht in:	Cancer detection and prevention 2007-01, Vol.31 (5), p.371-374
Hauptverfasser:	de Vasconcellos Meissner, Rosely, ScD, Niskier Ferreira Barbosa, Rodrigo, BsC, Veríssimo Fernandes, José, ScD, Medeiros Galvão, Tatiana, BS, Oliveira Galvão, Ana Flávia, BS, de Medeiros Oliveira, Gustavo Henrique, BS
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Age of Onset Brazil Brazilian population Cancer Cancer risk factor Carcinoma - genetics Cervical cancer Cervix carcinoma Confidence intervals DNA polymorphism Epidemiology Female Genotype & phenotype Hematology, Oncology and Palliative Medicine HPV Human papillomavirus Humans Immunoblotting MDM2 gene MDM2 promoter polymorphism Middle Aged Papillomavirus Infections - epidemiology Polymerase Chain Reaction Polymorphism, Single Nucleotide Primer-introduced restriction analysis (PIRA) PCR Promoter Regions, Genetic - genetics Proteins Proto-Oncogene Proteins c-mdm2 - genetics Risk factors SNP309 Uterine Cervical Neoplasms - genetics
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