Transmission distortion of BDNF variants to bipolar disorder type I patients from a south american population isolate
Recent reports have implicated polymorphisms in the brain derived neurotrophic factor (BDNF) gene region in the etiology of several psychiatric phenotypes, including bipolar disorder. Significant disease association has been reported for the G allele at SNP rs6265, which encodes for Valine at positi...
Gespeichert in:
| Veröffentlicht in: | American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2006-07, Vol.141B (5), p.435-439 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 439 |
|---|---|
| container_issue | 5 |
| container_start_page | 435 |
| container_title | American journal of medical genetics. Part B, Neuropsychiatric genetics |
| container_volume | 141B |
| creator | Kremeyer, Barbara Herzberg, Ibi Garcia, Jenny Kerr, Emily Duque, Constanza Parra, Vicky Vega, Jorge Lopez, Carlos Palacio, Carlos Bedoya, Gabriel Ospina, Jorge Ruiz-Linares, Andres |
| description | Recent reports have implicated polymorphisms in the brain derived neurotrophic factor (BDNF) gene region in the etiology of several psychiatric phenotypes, including bipolar disorder. Significant disease association has been reported for the G allele at SNP rs6265, which encodes for Valine at position 66 of BDNF (Val66Met), an apparently functional variant of this key BDNF. Here we examined a sample of 224 bipolar type I patients and available parents (comprising a total of 212 nuclear families) ascertained in a South American population isolate (Antioquia, Colombia). We tested for transmission distortion to bipolar patients of alleles at the rs6265 polymorphism and at a microsatellite marker 1.3 kb away from this SNP. Significant excess transmission of the rs6265 G allele to cases was observed (χ2 = 10.77, d.f. = 1, P = 0.001). Two‐locus haplotype analysis showed a significant global transmission distortion (χ2 = 16.059, d.f. = 7, P = 0.025) with an excess transmission of a haplotype comprising the rs6265 G allele and microsatellite allele 227. These results are consistent with previous studies pointing to a role for BDNF in susceptibility to mood disorders. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajmg.b.30354 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_19745260</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19745260</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4674-dff58a02d33d89179b6d6b3def5006b535d508ae84ba57f17a1cafb384aa2e993</originalsourceid><addsrcrecordid>eNp9kUFv1DAQhSNERUvhxhn5Aiey2LEdJ8e20G2r7gLSInqzxrENLkkc7ATYf4_T3bY3TvMO33szfs6yVwQvCMbFe7jtvi_UgmLK2ZPsiHBe5KziN08fNCOH2fMYbzGmmAvxLDskpWCkZuQomzYB-ti5GJ3vkXZx9GGcpbfo9MP6HP2G4KAfIxo9Um7wLYQZ80GbgMbtYNAlGmB0ZmZs8B0CFP00_kDQmeAa6NHgh6mFu9RkTMq8yA4stNG83M_j7Ov5x83ZRX79aXl5dnKdNyxdmGtreQW40JTqqiaiVqUuFdXGcoxLxSnXHFdgKqaAC0sEkAasohUDKExd0-Ps7S53CP7XZOIo00sb07bQGz9FSWrBeFHiBL7bgU3wMQZj5RBcB2ErCZZzzXKuWSp5V3PCX-9zJ9UZ_Qjve03Amz0AsYHWppIbFx85URNG6zJxdMf9ca3Z_nepPLlaLe_X5ztX-i7z98EF4acsBRVcflsv5Zeb1WpdFJ_lhv4DSOWnzw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19745260</pqid></control><display><type>article</type><title>Transmission distortion of BDNF variants to bipolar disorder type I patients from a south american population isolate</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Kremeyer, Barbara ; Herzberg, Ibi ; Garcia, Jenny ; Kerr, Emily ; Duque, Constanza ; Parra, Vicky ; Vega, Jorge ; Lopez, Carlos ; Palacio, Carlos ; Bedoya, Gabriel ; Ospina, Jorge ; Ruiz-Linares, Andres</creator><creatorcontrib>Kremeyer, Barbara ; Herzberg, Ibi ; Garcia, Jenny ; Kerr, Emily ; Duque, Constanza ; Parra, Vicky ; Vega, Jorge ; Lopez, Carlos ; Palacio, Carlos ; Bedoya, Gabriel ; Ospina, Jorge ; Ruiz-Linares, Andres</creatorcontrib><description>Recent reports have implicated polymorphisms in the brain derived neurotrophic factor (BDNF) gene region in the etiology of several psychiatric phenotypes, including bipolar disorder. Significant disease association has been reported for the G allele at SNP rs6265, which encodes for Valine at position 66 of BDNF (Val66Met), an apparently functional variant of this key BDNF. Here we examined a sample of 224 bipolar type I patients and available parents (comprising a total of 212 nuclear families) ascertained in a South American population isolate (Antioquia, Colombia). We tested for transmission distortion to bipolar patients of alleles at the rs6265 polymorphism and at a microsatellite marker 1.3 kb away from this SNP. Significant excess transmission of the rs6265 G allele to cases was observed (χ2 = 10.77, d.f. = 1, P = 0.001). Two‐locus haplotype analysis showed a significant global transmission distortion (χ2 = 16.059, d.f. = 7, P = 0.025) with an excess transmission of a haplotype comprising the rs6265 G allele and microsatellite allele 227. These results are consistent with previous studies pointing to a role for BDNF in susceptibility to mood disorders. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 1552-4841</identifier><identifier>EISSN: 1552-485X</identifier><identifier>DOI: 10.1002/ajmg.b.30354</identifier><identifier>PMID: 16741941</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult and adolescent clinical studies ; Alleles ; Antioquia ; BDNF ; Biological and medical sciences ; bipolar disorder ; Bipolar Disorder - genetics ; Brain-Derived Neurotrophic Factor - genetics ; Colombia ; Dinucleotide Repeats - genetics ; Family Health ; Female ; Gene Frequency ; Haplotypes ; Humans ; Linkage Disequilibrium ; Male ; Medical sciences ; Miscellaneous ; Mood disorders ; Mutation, Missense ; Nuclear Family ; Polymorphism, Single Nucleotide ; population isolate ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; TDT</subject><ispartof>American journal of medical genetics. Part B, Neuropsychiatric genetics, 2006-07, Vol.141B (5), p.435-439</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>2006 INIST-CNRS</rights><rights>(c) 2006 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4674-dff58a02d33d89179b6d6b3def5006b535d508ae84ba57f17a1cafb384aa2e993</citedby><cites>FETCH-LOGICAL-c4674-dff58a02d33d89179b6d6b3def5006b535d508ae84ba57f17a1cafb384aa2e993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajmg.b.30354$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajmg.b.30354$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27925,27926,45575,45576</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17914396$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16741941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kremeyer, Barbara</creatorcontrib><creatorcontrib>Herzberg, Ibi</creatorcontrib><creatorcontrib>Garcia, Jenny</creatorcontrib><creatorcontrib>Kerr, Emily</creatorcontrib><creatorcontrib>Duque, Constanza</creatorcontrib><creatorcontrib>Parra, Vicky</creatorcontrib><creatorcontrib>Vega, Jorge</creatorcontrib><creatorcontrib>Lopez, Carlos</creatorcontrib><creatorcontrib>Palacio, Carlos</creatorcontrib><creatorcontrib>Bedoya, Gabriel</creatorcontrib><creatorcontrib>Ospina, Jorge</creatorcontrib><creatorcontrib>Ruiz-Linares, Andres</creatorcontrib><title>Transmission distortion of BDNF variants to bipolar disorder type I patients from a south american population isolate</title><title>American journal of medical genetics. Part B, Neuropsychiatric genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>Recent reports have implicated polymorphisms in the brain derived neurotrophic factor (BDNF) gene region in the etiology of several psychiatric phenotypes, including bipolar disorder. Significant disease association has been reported for the G allele at SNP rs6265, which encodes for Valine at position 66 of BDNF (Val66Met), an apparently functional variant of this key BDNF. Here we examined a sample of 224 bipolar type I patients and available parents (comprising a total of 212 nuclear families) ascertained in a South American population isolate (Antioquia, Colombia). We tested for transmission distortion to bipolar patients of alleles at the rs6265 polymorphism and at a microsatellite marker 1.3 kb away from this SNP. Significant excess transmission of the rs6265 G allele to cases was observed (χ2 = 10.77, d.f. = 1, P = 0.001). Two‐locus haplotype analysis showed a significant global transmission distortion (χ2 = 16.059, d.f. = 7, P = 0.025) with an excess transmission of a haplotype comprising the rs6265 G allele and microsatellite allele 227. These results are consistent with previous studies pointing to a role for BDNF in susceptibility to mood disorders. © 2006 Wiley‐Liss, Inc.</description><subject>Adult and adolescent clinical studies</subject><subject>Alleles</subject><subject>Antioquia</subject><subject>BDNF</subject><subject>Biological and medical sciences</subject><subject>bipolar disorder</subject><subject>Bipolar Disorder - genetics</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Colombia</subject><subject>Dinucleotide Repeats - genetics</subject><subject>Family Health</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Mood disorders</subject><subject>Mutation, Missense</subject><subject>Nuclear Family</subject><subject>Polymorphism, Single Nucleotide</subject><subject>population isolate</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>TDT</subject><issn>1552-4841</issn><issn>1552-485X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAQhSNERUvhxhn5Aiey2LEdJ8e20G2r7gLSInqzxrENLkkc7ATYf4_T3bY3TvMO33szfs6yVwQvCMbFe7jtvi_UgmLK2ZPsiHBe5KziN08fNCOH2fMYbzGmmAvxLDskpWCkZuQomzYB-ti5GJ3vkXZx9GGcpbfo9MP6HP2G4KAfIxo9Um7wLYQZ80GbgMbtYNAlGmB0ZmZs8B0CFP00_kDQmeAa6NHgh6mFu9RkTMq8yA4stNG83M_j7Ov5x83ZRX79aXl5dnKdNyxdmGtreQW40JTqqiaiVqUuFdXGcoxLxSnXHFdgKqaAC0sEkAasohUDKExd0-Ps7S53CP7XZOIo00sb07bQGz9FSWrBeFHiBL7bgU3wMQZj5RBcB2ErCZZzzXKuWSp5V3PCX-9zJ9UZ_Qjve03Amz0AsYHWppIbFx85URNG6zJxdMf9ca3Z_nepPLlaLe_X5ztX-i7z98EF4acsBRVcflsv5Zeb1WpdFJ_lhv4DSOWnzw</recordid><startdate>20060705</startdate><enddate>20060705</enddate><creator>Kremeyer, Barbara</creator><creator>Herzberg, Ibi</creator><creator>Garcia, Jenny</creator><creator>Kerr, Emily</creator><creator>Duque, Constanza</creator><creator>Parra, Vicky</creator><creator>Vega, Jorge</creator><creator>Lopez, Carlos</creator><creator>Palacio, Carlos</creator><creator>Bedoya, Gabriel</creator><creator>Ospina, Jorge</creator><creator>Ruiz-Linares, Andres</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20060705</creationdate><title>Transmission distortion of BDNF variants to bipolar disorder type I patients from a south american population isolate</title><author>Kremeyer, Barbara ; Herzberg, Ibi ; Garcia, Jenny ; Kerr, Emily ; Duque, Constanza ; Parra, Vicky ; Vega, Jorge ; Lopez, Carlos ; Palacio, Carlos ; Bedoya, Gabriel ; Ospina, Jorge ; Ruiz-Linares, Andres</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4674-dff58a02d33d89179b6d6b3def5006b535d508ae84ba57f17a1cafb384aa2e993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Alleles</topic><topic>Antioquia</topic><topic>BDNF</topic><topic>Biological and medical sciences</topic><topic>bipolar disorder</topic><topic>Bipolar Disorder - genetics</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Colombia</topic><topic>Dinucleotide Repeats - genetics</topic><topic>Family Health</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Mood disorders</topic><topic>Mutation, Missense</topic><topic>Nuclear Family</topic><topic>Polymorphism, Single Nucleotide</topic><topic>population isolate</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>TDT</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kremeyer, Barbara</creatorcontrib><creatorcontrib>Herzberg, Ibi</creatorcontrib><creatorcontrib>Garcia, Jenny</creatorcontrib><creatorcontrib>Kerr, Emily</creatorcontrib><creatorcontrib>Duque, Constanza</creatorcontrib><creatorcontrib>Parra, Vicky</creatorcontrib><creatorcontrib>Vega, Jorge</creatorcontrib><creatorcontrib>Lopez, Carlos</creatorcontrib><creatorcontrib>Palacio, Carlos</creatorcontrib><creatorcontrib>Bedoya, Gabriel</creatorcontrib><creatorcontrib>Ospina, Jorge</creatorcontrib><creatorcontrib>Ruiz-Linares, Andres</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>American journal of medical genetics. Part B, Neuropsychiatric genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kremeyer, Barbara</au><au>Herzberg, Ibi</au><au>Garcia, Jenny</au><au>Kerr, Emily</au><au>Duque, Constanza</au><au>Parra, Vicky</au><au>Vega, Jorge</au><au>Lopez, Carlos</au><au>Palacio, Carlos</au><au>Bedoya, Gabriel</au><au>Ospina, Jorge</au><au>Ruiz-Linares, Andres</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmission distortion of BDNF variants to bipolar disorder type I patients from a south american population isolate</atitle><jtitle>American journal of medical genetics. Part B, Neuropsychiatric genetics</jtitle><addtitle>Am. J. Med. Genet</addtitle><date>2006-07-05</date><risdate>2006</risdate><volume>141B</volume><issue>5</issue><spage>435</spage><epage>439</epage><pages>435-439</pages><issn>1552-4841</issn><eissn>1552-485X</eissn><abstract>Recent reports have implicated polymorphisms in the brain derived neurotrophic factor (BDNF) gene region in the etiology of several psychiatric phenotypes, including bipolar disorder. Significant disease association has been reported for the G allele at SNP rs6265, which encodes for Valine at position 66 of BDNF (Val66Met), an apparently functional variant of this key BDNF. Here we examined a sample of 224 bipolar type I patients and available parents (comprising a total of 212 nuclear families) ascertained in a South American population isolate (Antioquia, Colombia). We tested for transmission distortion to bipolar patients of alleles at the rs6265 polymorphism and at a microsatellite marker 1.3 kb away from this SNP. Significant excess transmission of the rs6265 G allele to cases was observed (χ2 = 10.77, d.f. = 1, P = 0.001). Two‐locus haplotype analysis showed a significant global transmission distortion (χ2 = 16.059, d.f. = 7, P = 0.025) with an excess transmission of a haplotype comprising the rs6265 G allele and microsatellite allele 227. These results are consistent with previous studies pointing to a role for BDNF in susceptibility to mood disorders. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16741941</pmid><doi>10.1002/ajmg.b.30354</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1552-4841 |
| ispartof | American journal of medical genetics. Part B, Neuropsychiatric genetics, 2006-07, Vol.141B (5), p.435-439 |
| issn | 1552-4841 1552-485X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_19745260 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult and adolescent clinical studies Alleles Antioquia BDNF Biological and medical sciences bipolar disorder Bipolar Disorder - genetics Brain-Derived Neurotrophic Factor - genetics Colombia Dinucleotide Repeats - genetics Family Health Female Gene Frequency Haplotypes Humans Linkage Disequilibrium Male Medical sciences Miscellaneous Mood disorders Mutation, Missense Nuclear Family Polymorphism, Single Nucleotide population isolate Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry TDT |
| title | Transmission distortion of BDNF variants to bipolar disorder type I patients from a south american population isolate |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T13%3A58%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Transmission%20distortion%20of%20BDNF%20variants%20to%20bipolar%20disorder%20type%20I%20patients%20from%20a%20south%20american%20population%20isolate&rft.jtitle=American%20journal%20of%20medical%20genetics.%20Part%20B,%20Neuropsychiatric%20genetics&rft.au=Kremeyer,%20Barbara&rft.date=2006-07-05&rft.volume=141B&rft.issue=5&rft.spage=435&rft.epage=439&rft.pages=435-439&rft.issn=1552-4841&rft.eissn=1552-485X&rft_id=info:doi/10.1002/ajmg.b.30354&rft_dat=%3Cproquest_cross%3E19745260%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19745260&rft_id=info:pmid/16741941&rfr_iscdi=true |