MCT-1 oncogene downregulates p53 and destabilizes genome structure in the response to DNA double-strand damage

Tumor suppressor p53 protein mediates checkpoint controls and the apoptotic program that are critical for maintaining genomic integrity and preventing tumorigenesis. Forced-induction of MCT-1 decreased p53 expression before and after genomic insults. While inhibiting protein synthesis, the levels of...

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Veröffentlicht in:	DNA repair 2007-09, Vol.6 (9), p.1319-1332
Hauptverfasser:	Hsu, Hsin-Ling, Choy, Chik On, Kasiappan, Ravi, Shih, Hung-Ju, Sawyer, Jeffrey R., Shu, Chung-Li, Chu, Kang-Lin, Chen, Yi-Rong, Hsu, Hsin-Fen, Gartenhaus, Ronald B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - metabolism Cell cycle checkpoint Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cells, Cultured Chromosomal Instability Comet Assay Cyclin-Dependent Kinase Inhibitor p21 - metabolism DNA Damage DNA Replication Down-Regulation Fibroblasts - cytology Fibroblasts - metabolism G1 Phase G2 Phase Histones - metabolism Humans Karyotyping Lung Neoplasms - metabolism Lung Neoplasms - pathology MAPK MCT-1 oncogene Mitogen-Activated Protein Kinase Kinases - metabolism Oncogene Proteins - genetics Oncogene Proteins - metabolism p21 p53 S Phase Translocation, Genetic Tumor Suppressor Protein p53 - metabolism
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