A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model

Her-2/neu is a well-characterized tumor-associated antigen overexpressed in human carcinomas such as breast cancer. Because Her-2/neu is a self-antigen with poor immunogenicity due to immunologic tolerance, active immunotherapy targeting Her-2/neu should incorporate methods to overcome immunologic t...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-08, Vol.67 (15), p.7477-7486
Hauptverfasser:	KO, Hyun-Jeong, KIM, Yeon-Jeong, KIM, Yun-Sun, CHANG, Woo-Sung, KO, Sung-Youl, CHANG, Sun-Young, SAKAGUCHI, Shimon, KANG, Chang-Yuil
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Antigens, CD - genetics Antigens, CD - immunology Antigens, CD - metabolism Antigens, Differentiation - genetics Antigens, Differentiation - immunology Antigens, Differentiation - metabolism Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - prevention & control CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Cell Proliferation Colonic Neoplasms - genetics Colonic Neoplasms - immunology Colonic Neoplasms - prevention & control Combined Modality Therapy CTLA-4 Antigen Cyclophosphamide - administration & dosage Dendritic Cells - immunology Dendritic Cells - metabolism Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Doxorubicin - administration & dosage Female Flow Cytometry Galactosylceramides - immunology Genetic Vectors - administration & dosage Glucocorticoid-Induced TNFR-Related Protein Humans Immunization Immunotherapy Medical sciences Mice Myeloid Cells - cytology Myeloid Cells - immunology Peptide Fragments - genetics Peptide Fragments - immunology Peptide Fragments - pharmacology Pharmacology. Drug treatments Receptor, ErbB-2 - genetics Receptor, ErbB-2 - immunology Receptors, Nerve Growth Factor - genetics Receptors, Nerve Growth Factor - metabolism Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - metabolism T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Regulatory Taxoids - administration & dosage Transfection Tumors Vaccines, DNA - administration & dosage
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