A lymphocytic choriomeningitis virus glycoprotein variant that is retained in the endoplasmic reticulum efficiently cross-primes CD8 super(+) T cell responses

Recent studies indicate that T cell cross-priming preferentially occurs against long-lived, stable proteins. We have studied cross-priming by using the glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV), a protein that normally is not MHC class I cross-presented. This study shows that a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-08, Vol.104 (33), p.13426-13431
Hauptverfasser:	Freigang, Stefan, Eschli, Bruno, Harris, Nicola, Geuking, Markus, Quirin, Katharina, Schrempf, Sabrina, Zellweger, Raphael, Weber, Jacqueline, Hengartner, Hans, Zinkernagel, Rolf M
Format:	Artikel
Sprache:	eng
Schlagworte:	Lymphocytic choriomeningitis virus
Online-Zugang:	Volltext
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