L-Carnitine ameliorates methotrexate-induced oxidative organ injury and inhibits leukocyte death

Methotrexate (MTX), a folic acid antagonist widely used for the treatment of a variety of tumors and inflammatory diseases, affects normal tissues that have a high rate of proliferation, including the hematopoietic cells of the bone marrow and the gastrointestinal mucosal cells. To elucidate the rol...

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Veröffentlicht in:	Cell biology and toxicology 2006-01, Vol.22 (1), p.47-60
Hauptverfasser:	Sener, G, Ekşioğlu-Demiralp, E, Cetiner, M, Ercan, F, Sirvanci, S, Gedik, N, Yeğen, B C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Bone marrow Carnitine - therapeutic use Collagen - metabolism Female Folic acid Free Radical Scavengers - therapeutic use Free radicals Glutathione - metabolism Ileum - drug effects Ileum - enzymology Ileum - metabolism Ileum - pathology Kidney - drug effects Kidney - enzymology Kidney - metabolism Kidney - pathology Leukocytes - drug effects Lipid Peroxides - metabolism Liver - drug effects Liver - enzymology Liver - metabolism Liver - pathology Male Methotrexate - adverse effects Oxidative Stress - drug effects Peroxidase - metabolism Rats Rats, Wistar
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