A methotrexate-associated lympholiferative disorder patient with gastrointestinal perforation
A 70-year-old woman was diagnosed with chronic rheumatoid arthritis and treated with methotrexate and prednisolone. She visited our hospital to determine the cause of her continuous fatigue and fever for the past three weeks. She consumed no food orally and was provided antibiotics because free air...
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| Veröffentlicht in: | Nihon Rōnen Igakkai zasshi 2017/10/25, Vol.54(4), pp.567-572 |
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| container_title | Nihon Rōnen Igakkai zasshi |
| container_volume | 54 |
| creator | Aota, Yasuo Nonaka, Tadahito Kimura, Sei Honda, Tadahiro Okuda, Yuko Watanabe, Tsubasa Fujiwara, Keitaro Yokoyama, Tomohisa Wakabayashi, Yukari Sakurai, Michio Gotoh, Akihiko |
| description | A 70-year-old woman was diagnosed with chronic rheumatoid arthritis and treated with methotrexate and prednisolone. She visited our hospital to determine the cause of her continuous fatigue and fever for the past three weeks. She consumed no food orally and was provided antibiotics because free air was found on computed tomography (CT). Intraperitoneal small lymphadenopathy and swelling of both adrenal glands was also found on CT, and MTX-associated lymphoproliferative disorder (MTX-LPD) was suspected. Am adrenal gland biopsy showed diffuse large B-cell lymphoma (DLBCL) associated with MTX-LPD. The causes of gastrointestinal perforation with collagen diseases have been reported to be functional gastrointestinal disorders with collagen diseases like amyloidosis, gastrointestinal infections in immunocompromised patients, and side effects of medication, such as steroids or NSAIDs and MTX. MTX-LPD is an uncommon side effect of methotrexate. To ensure its appropriate diagnosis and treatment, it is important to improve the degree of recognition of MTX-LPD, and a prompt response is needed. |
| doi_str_mv | 10.3143/geriatrics.54.567 |
| format | Article |
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She visited our hospital to determine the cause of her continuous fatigue and fever for the past three weeks. She consumed no food orally and was provided antibiotics because free air was found on computed tomography (CT). Intraperitoneal small lymphadenopathy and swelling of both adrenal glands was also found on CT, and MTX-associated lymphoproliferative disorder (MTX-LPD) was suspected. Am adrenal gland biopsy showed diffuse large B-cell lymphoma (DLBCL) associated with MTX-LPD. The causes of gastrointestinal perforation with collagen diseases have been reported to be functional gastrointestinal disorders with collagen diseases like amyloidosis, gastrointestinal infections in immunocompromised patients, and side effects of medication, such as steroids or NSAIDs and MTX. MTX-LPD is an uncommon side effect of methotrexate. To ensure its appropriate diagnosis and treatment, it is important to improve the degree of recognition of MTX-LPD, and a prompt response is needed.</description><identifier>ISSN: 0300-9173</identifier><identifier>DOI: 10.3143/geriatrics.54.567</identifier><identifier>PMID: 29213000</identifier><language>jpn</language><publisher>Japan: The Japan Geriatrics Society</publisher><subject>Elderly ; Gastrointestinal perforation ; Malignant lymphoma ; Methotrexate-associated lymphoproliferative disorder ; MTX-LPD</subject><ispartof>Nippon Ronen Igakkai Zasshi. 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To ensure its appropriate diagnosis and treatment, it is important to improve the degree of recognition of MTX-LPD, and a prompt response is needed.</description><subject>Elderly</subject><subject>Gastrointestinal perforation</subject><subject>Malignant lymphoma</subject><subject>Methotrexate-associated lymphoproliferative disorder</subject><subject>MTX-LPD</subject><issn>0300-9173</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpFkMFOwzAMhnMAsTF4AC6oRy4dSZOs63GaYCAhcYEjqpzEXTO1TUkyYG9Pp40hWbZsf_5l_YTcMDrlTPD7NXoL0VsdplJM5Sw_I2PKKU0LlvMRuQxhQ6mUYpZdkFFWZGzY0TH5WCQtxtpFjz8QMYUQnB6E0CTNru1r19gKPUT7hYmxwXmDPumHHruYfNtYJ2sI0TvbRQzRdtAkPfrK7U9cd0XOK2gCXh_rhLw_Prwtn9KX19XzcvGSblhBYzoTEpRSgpncVPOKMpgDZEKArIQ0nHOV5ZTxTBkDKBTNNYBQw0AbmEuu-YTcHXR77z63wyNla4PGpoEO3TaUrMjFIEBFMaC3R3SrWjRl720Lflf-WTIAqwOwCRHWeALAR6sbLP-NLqUoxT7tY5afCF2DL7Hjv24hgLg</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Aota, Yasuo</creator><creator>Nonaka, Tadahito</creator><creator>Kimura, Sei</creator><creator>Honda, Tadahiro</creator><creator>Okuda, Yuko</creator><creator>Watanabe, Tsubasa</creator><creator>Fujiwara, Keitaro</creator><creator>Yokoyama, Tomohisa</creator><creator>Wakabayashi, Yukari</creator><creator>Sakurai, Michio</creator><creator>Gotoh, Akihiko</creator><general>The Japan Geriatrics Society</general><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>A methotrexate-associated lympholiferative disorder patient with gastrointestinal perforation</title><author>Aota, Yasuo ; Nonaka, Tadahito ; Kimura, Sei ; Honda, Tadahiro ; Okuda, Yuko ; Watanabe, Tsubasa ; Fujiwara, Keitaro ; Yokoyama, Tomohisa ; Wakabayashi, Yukari ; Sakurai, Michio ; Gotoh, Akihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j190t-645abbb41d7df8f01a8aa244a5f45d333b270132bddae4b07caa4b132cda853c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>2017</creationdate><topic>Elderly</topic><topic>Gastrointestinal perforation</topic><topic>Malignant lymphoma</topic><topic>Methotrexate-associated lymphoproliferative disorder</topic><topic>MTX-LPD</topic><toplevel>online_resources</toplevel><creatorcontrib>Aota, Yasuo</creatorcontrib><creatorcontrib>Nonaka, Tadahito</creatorcontrib><creatorcontrib>Kimura, Sei</creatorcontrib><creatorcontrib>Honda, Tadahiro</creatorcontrib><creatorcontrib>Okuda, Yuko</creatorcontrib><creatorcontrib>Watanabe, Tsubasa</creatorcontrib><creatorcontrib>Fujiwara, Keitaro</creatorcontrib><creatorcontrib>Yokoyama, Tomohisa</creatorcontrib><creatorcontrib>Wakabayashi, Yukari</creatorcontrib><creatorcontrib>Sakurai, Michio</creatorcontrib><creatorcontrib>Gotoh, Akihiko</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nihon Rōnen Igakkai zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aota, Yasuo</au><au>Nonaka, Tadahito</au><au>Kimura, Sei</au><au>Honda, Tadahiro</au><au>Okuda, Yuko</au><au>Watanabe, Tsubasa</au><au>Fujiwara, Keitaro</au><au>Yokoyama, Tomohisa</au><au>Wakabayashi, Yukari</au><au>Sakurai, Michio</au><au>Gotoh, Akihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A methotrexate-associated lympholiferative disorder patient with gastrointestinal perforation</atitle><jtitle>Nihon Rōnen Igakkai zasshi</jtitle><addtitle>Nippon Ronen Igakkai Zasshi</addtitle><date>2017</date><risdate>2017</risdate><volume>54</volume><issue>4</issue><spage>567</spage><epage>572</epage><pages>567-572</pages><issn>0300-9173</issn><abstract>A 70-year-old woman was diagnosed with chronic rheumatoid arthritis and treated with methotrexate and prednisolone. She visited our hospital to determine the cause of her continuous fatigue and fever for the past three weeks. She consumed no food orally and was provided antibiotics because free air was found on computed tomography (CT). Intraperitoneal small lymphadenopathy and swelling of both adrenal glands was also found on CT, and MTX-associated lymphoproliferative disorder (MTX-LPD) was suspected. Am adrenal gland biopsy showed diffuse large B-cell lymphoma (DLBCL) associated with MTX-LPD. The causes of gastrointestinal perforation with collagen diseases have been reported to be functional gastrointestinal disorders with collagen diseases like amyloidosis, gastrointestinal infections in immunocompromised patients, and side effects of medication, such as steroids or NSAIDs and MTX. MTX-LPD is an uncommon side effect of methotrexate. To ensure its appropriate diagnosis and treatment, it is important to improve the degree of recognition of MTX-LPD, and a prompt response is needed.</abstract><cop>Japan</cop><pub>The Japan Geriatrics Society</pub><pmid>29213000</pmid><doi>10.3143/geriatrics.54.567</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2017/10/25, Vol.54(4), pp.567-572 |
| issn | 0300-9173 |
| language | jpn |
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| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals |
| subjects | Elderly Gastrointestinal perforation Malignant lymphoma Methotrexate-associated lymphoproliferative disorder MTX-LPD |
| title | A methotrexate-associated lympholiferative disorder patient with gastrointestinal perforation |
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