Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges
Obsessive-compulsive disorder (OCD) is a prevalent and debilitating condition, characterized by intrusive thoughts and repetitive behavior. Animal models of OCD arguably have the potential to contribute to our understanding of the condition. Deer mice (Permomyscus maniculatus bairdii) are characteri...
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| Veröffentlicht in: | Metabolic brain disease 2018-04, Vol.33 (2), p.443-455 |
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| creator | Wolmarans, De Wet Scheepers, Isabella M. Stein, Dan J. Harvey, Brian H. |
| description | Obsessive-compulsive disorder (OCD) is a prevalent and debilitating condition, characterized by intrusive thoughts and repetitive behavior. Animal models of OCD arguably have the potential to contribute to our understanding of the condition. Deer mice
(Permomyscus maniculatus bairdii)
are characterized by stereotypic behavior which is reminiscent of OCD symptomology, and which may serve as a naturalistic animal model of this disorder. Moreover, a range of deer mouse repetitive behaviors may be representative of different compulsive-like phenotypes. This paper will review work on deer mouse behavior, and evaluate the extent to which this serves as a valid and useful model of OCD. We argue that findings over the past decade indicate that the deer mouse model has face, construct and predictive validity. |
| doi_str_mv | 10.1007/s11011-017-0161-7 |
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(Permomyscus maniculatus bairdii)
are characterized by stereotypic behavior which is reminiscent of OCD symptomology, and which may serve as a naturalistic animal model of this disorder. Moreover, a range of deer mouse repetitive behaviors may be representative of different compulsive-like phenotypes. This paper will review work on deer mouse behavior, and evaluate the extent to which this serves as a valid and useful model of OCD. We argue that findings over the past decade indicate that the deer mouse model has face, construct and predictive validity.</description><identifier>ISSN: 0885-7490</identifier><identifier>EISSN: 1573-7365</identifier><identifier>DOI: 10.1007/s11011-017-0161-7</identifier><identifier>PMID: 29214602</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animal behavior ; Animal models ; Animals ; Behavior, Animal - physiology ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Disease Models, Animal ; Humans ; Mammals ; Metabolic Diseases ; Neurology ; Neurosciences ; Neuroses ; Obsessive compulsive disorder ; Obsessive-Compulsive Disorder - metabolism ; Obsessive-Compulsive Disorder - physiopathology ; Oncology ; Original Article ; Peromyscus - metabolism ; Peromyscus maniculatus ; Rodents ; Stereotyped behavior ; Stereotyped Behavior - physiology ; Symptomology</subject><ispartof>Metabolic brain disease, 2018-04, Vol.33 (2), p.443-455</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2017</rights><rights>Metabolic Brain Disease is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-41387e171c85f5083c088b231ec00f1c40fe1933d82a4d60759ad0cbca0f3a013</citedby><cites>FETCH-LOGICAL-c372t-41387e171c85f5083c088b231ec00f1c40fe1933d82a4d60759ad0cbca0f3a013</cites><orcidid>0000-0002-3440-4869</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11011-017-0161-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11011-017-0161-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29214602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wolmarans, De Wet</creatorcontrib><creatorcontrib>Scheepers, Isabella M.</creatorcontrib><creatorcontrib>Stein, Dan J.</creatorcontrib><creatorcontrib>Harvey, Brian H.</creatorcontrib><title>Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges</title><title>Metabolic brain disease</title><addtitle>Metab Brain Dis</addtitle><addtitle>Metab Brain Dis</addtitle><description>Obsessive-compulsive disorder (OCD) is a prevalent and debilitating condition, characterized by intrusive thoughts and repetitive behavior. Animal models of OCD arguably have the potential to contribute to our understanding of the condition. Deer mice
(Permomyscus maniculatus bairdii)
are characterized by stereotypic behavior which is reminiscent of OCD symptomology, and which may serve as a naturalistic animal model of this disorder. Moreover, a range of deer mouse repetitive behaviors may be representative of different compulsive-like phenotypes. This paper will review work on deer mouse behavior, and evaluate the extent to which this serves as a valid and useful model of OCD. We argue that findings over the past decade indicate that the deer mouse model has face, construct and predictive validity.</description><subject>Animal behavior</subject><subject>Animal models</subject><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Disease Models, Animal</subject><subject>Humans</subject><subject>Mammals</subject><subject>Metabolic Diseases</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Neuroses</subject><subject>Obsessive compulsive disorder</subject><subject>Obsessive-Compulsive Disorder - metabolism</subject><subject>Obsessive-Compulsive Disorder - physiopathology</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Peromyscus - metabolism</subject><subject>Peromyscus maniculatus</subject><subject>Rodents</subject><subject>Stereotyped behavior</subject><subject>Stereotyped Behavior - physiology</subject><subject>Symptomology</subject><issn>0885-7490</issn><issn>1573-7365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc-KFDEQxoMo7jj6AF4k4MVLa1Wne9LtTRb_wYIe9Nykk2rNknTGVEfYJ_C1zTiriOAh5CP51VdJfUI8RniOAPoFIwJiA6jrOmCj74gd9lo1Wh36u2IHw9A3uhvhQjxgvgYA1eN4X1y0Y4vdAdqd-PGRcoo3bAvLaFZvSzBb1bPx2XkvDUsj13qUTfC8eVupGKs2q4zJUZBpkWlmYvbfqbEpHks4Sek8p-wov5S25EzrJnn7ZW1WJ5dSHUnaryYEWr8QPxT3FhOYHt3ue_H5zetPl--aqw9v31--umqs0u3WdKgGTajRDv3Sw6Bs_ePcKiQLsKDtYCEclXJDazp3AN2PxoGdrYFFGUC1F8_OvsecvhXibYqeLYVgVkqFJxx1V2eqqsdePP0HvU4lr_V1J0q1I2iESuGZsjkxZ1qmY_bR5JsJYTqlNJ1TmmpK0ymlSdeaJ7fOZY7k_lT8jqUC7RngelXHk_9q_V_Xn9Nsnug</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Wolmarans, De Wet</creator><creator>Scheepers, Isabella M.</creator><creator>Stein, Dan J.</creator><creator>Harvey, Brian H.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3440-4869</orcidid></search><sort><creationdate>20180401</creationdate><title>Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges</title><author>Wolmarans, De Wet ; Scheepers, Isabella M. ; Stein, Dan J. ; Harvey, Brian H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-41387e171c85f5083c088b231ec00f1c40fe1933d82a4d60759ad0cbca0f3a013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animal behavior</topic><topic>Animal models</topic><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Disease Models, Animal</topic><topic>Humans</topic><topic>Mammals</topic><topic>Metabolic Diseases</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Neuroses</topic><topic>Obsessive compulsive disorder</topic><topic>Obsessive-Compulsive Disorder - metabolism</topic><topic>Obsessive-Compulsive Disorder - physiopathology</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Peromyscus - metabolism</topic><topic>Peromyscus maniculatus</topic><topic>Rodents</topic><topic>Stereotyped behavior</topic><topic>Stereotyped Behavior - physiology</topic><topic>Symptomology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wolmarans, De Wet</creatorcontrib><creatorcontrib>Scheepers, Isabella M.</creatorcontrib><creatorcontrib>Stein, Dan J.</creatorcontrib><creatorcontrib>Harvey, Brian H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolic brain disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wolmarans, De Wet</au><au>Scheepers, Isabella M.</au><au>Stein, Dan J.</au><au>Harvey, Brian H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges</atitle><jtitle>Metabolic brain disease</jtitle><stitle>Metab Brain Dis</stitle><addtitle>Metab Brain Dis</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>33</volume><issue>2</issue><spage>443</spage><epage>455</epage><pages>443-455</pages><issn>0885-7490</issn><eissn>1573-7365</eissn><abstract>Obsessive-compulsive disorder (OCD) is a prevalent and debilitating condition, characterized by intrusive thoughts and repetitive behavior. Animal models of OCD arguably have the potential to contribute to our understanding of the condition. Deer mice
(Permomyscus maniculatus bairdii)
are characterized by stereotypic behavior which is reminiscent of OCD symptomology, and which may serve as a naturalistic animal model of this disorder. Moreover, a range of deer mouse repetitive behaviors may be representative of different compulsive-like phenotypes. This paper will review work on deer mouse behavior, and evaluate the extent to which this serves as a valid and useful model of OCD. We argue that findings over the past decade indicate that the deer mouse model has face, construct and predictive validity.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29214602</pmid><doi>10.1007/s11011-017-0161-7</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-3440-4869</orcidid></addata></record> |
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| subjects | Animal behavior Animal models Animals Behavior, Animal - physiology Biochemistry Biomedical and Life Sciences Biomedicine Disease Models, Animal Humans Mammals Metabolic Diseases Neurology Neurosciences Neuroses Obsessive compulsive disorder Obsessive-Compulsive Disorder - metabolism Obsessive-Compulsive Disorder - physiopathology Oncology Original Article Peromyscus - metabolism Peromyscus maniculatus Rodents Stereotyped behavior Stereotyped Behavior - physiology Symptomology |
| title | Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges |
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