Gender‐specific polygenic control of ethylnitrosourea‐induced oncogenesis in the rat peripheral nervous system

The inbred BD rat strains constitute a model system for analysis of the genetic basis of susceptibility or resistance to the development of neural tumors, as they exhibit distinct strain‐specific differences regarding the sensitivity to tumor induction by the alkylating carcinogen N‐ethyl‐N‐nitrosou...

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Veröffentlicht in:	International journal of cancer 2006-01, Vol.118 (1), p.108-114
Hauptverfasser:	Koelsch, Bernd U., Fischer, Christine, Neibecker, Markus, Schmitt, Nina, Schmidt, Ortrud, Rajewsky, Manfred F., Kindler‐Röhrborn, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - toxicity Animal tumors. Experimental tumors Animals association analysis Biological and medical sciences carcinogenesis Cell Transformation, Neoplastic - chemically induced Chromosome Mapping Ethylnitrosourea - toxicity ethylni‐trosourea Experimental nervous system tumors Female gender‐specificity Genetic Predisposition to Disease logistic model Male Medical sciences Multifactorial Inheritance Neurilemmoma - chemically induced Neurilemmoma - genetics peripheral nervous system Peripheral Nervous System Neoplasms - chemically induced Peripheral Nervous System Neoplasms - genetics rat Rats Rats, Inbred Strains rodents Sex Factors susceptibility gene loci Tumors
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