Measurement of Asbestos Fibre Concentrations in Fluid of Repeated Bro-Choalveolar Lavages of Exposed Workers
Objectives: The aim of this study was to assess the reliability of asbestos fibre concentration in bronchoalveolar lavage fluid (BALF) by carrying out the mineralogical analysis of BALF at different times in the same patient and comparing the results. Methods: Twenty two patients underwent diagnosti...
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| Veröffentlicht in: | The Annals of occupational hygiene 2007-07, Vol.51 (5), p.495-500 |
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| creator | SARTORELLI, P ROMEO, R SCANCARELLO, G MONTOMOLI, L MUZZUPAPPA, C BARABESI, L |
| description | Objectives: The aim of this study was to assess the reliability of asbestos fibre concentration in bronchoalveolar lavage fluid (BALF) by carrying out the mineralogical analysis of BALF at different times in the same patient and comparing the results.
Methods: Twenty two patients underwent diagnostic fibreoptic bronchoscopy twice: the first was to assess the past asbestos exposure and the second for different clinical reasons. Mineralogical analysis of BALF was carried out.
Results: In 16 patients (72.7%), a reduction of concentration in BALF of all asbestos fibres was observed. The concentrations of both chrysotile and amphiboles in the first bronchoalveolar lavage (BAL) were related to their concentrations in the second BAL and the observed differences were not statistically significant. A significant decrease in asbestos body concentration between the first and the second BAL was found (Wilcoxon test, P < 0.01).
Conclusions: The reliability of the fibre concentration in BALF as a marker of past asbestos exposure seems quite good. In most cases, it allows us to distinguish workers in different classes of exposure and gives useful information on the pattern of exposure. Uncertainties related in general to lung residues and in particular to mineralogical analysis of BALF (mainly due to the high coefficient of variation (CV) at low fibre concentrations and the results of the statistical analysis on total fibres) suggest that this biomarker is more likely suitable for a qualitative/categorical approach to exposure assessment than a quantitative one. |
| doi_str_mv | 10.1093/annhyg/mem014 |
| format | Article |
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Methods: Twenty two patients underwent diagnostic fibreoptic bronchoscopy twice: the first was to assess the past asbestos exposure and the second for different clinical reasons. Mineralogical analysis of BALF was carried out.
Results: In 16 patients (72.7%), a reduction of concentration in BALF of all asbestos fibres was observed. The concentrations of both chrysotile and amphiboles in the first bronchoalveolar lavage (BAL) were related to their concentrations in the second BAL and the observed differences were not statistically significant. A significant decrease in asbestos body concentration between the first and the second BAL was found (Wilcoxon test, P < 0.01).
Conclusions: The reliability of the fibre concentration in BALF as a marker of past asbestos exposure seems quite good. In most cases, it allows us to distinguish workers in different classes of exposure and gives useful information on the pattern of exposure. Uncertainties related in general to lung residues and in particular to mineralogical analysis of BALF (mainly due to the high coefficient of variation (CV) at low fibre concentrations and the results of the statistical analysis on total fibres) suggest that this biomarker is more likely suitable for a qualitative/categorical approach to exposure assessment than a quantitative one.</description><identifier>ISSN: 0003-4878</identifier><identifier>EISSN: 1475-3162</identifier><identifier>DOI: 10.1093/annhyg/mem014</identifier><identifier>PMID: 17456581</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Aged ; Asbestos - analysis ; Bronchoalveolar Lavage Fluid ; Bronchoscopy ; Humans ; Male ; Microscopy, Electron ; Middle Aged ; Mineral Fibers - analysis ; Occupational Exposure - adverse effects ; Occupational Exposure - analysis ; Reproducibility of Results</subject><ispartof>The Annals of occupational hygiene, 2007-07, Vol.51 (5), p.495-500</ispartof><rights>The Author 2007. Published by Oxford University Press on behalf of the British Occupational Hygiene Society 2007</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17456581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SARTORELLI, P</creatorcontrib><creatorcontrib>ROMEO, R</creatorcontrib><creatorcontrib>SCANCARELLO, G</creatorcontrib><creatorcontrib>MONTOMOLI, L</creatorcontrib><creatorcontrib>MUZZUPAPPA, C</creatorcontrib><creatorcontrib>BARABESI, L</creatorcontrib><title>Measurement of Asbestos Fibre Concentrations in Fluid of Repeated Bro-Choalveolar Lavages of Exposed Workers</title><title>The Annals of occupational hygiene</title><addtitle>Ann Occup Hyg</addtitle><description>Objectives: The aim of this study was to assess the reliability of asbestos fibre concentration in bronchoalveolar lavage fluid (BALF) by carrying out the mineralogical analysis of BALF at different times in the same patient and comparing the results.
Methods: Twenty two patients underwent diagnostic fibreoptic bronchoscopy twice: the first was to assess the past asbestos exposure and the second for different clinical reasons. Mineralogical analysis of BALF was carried out.
Results: In 16 patients (72.7%), a reduction of concentration in BALF of all asbestos fibres was observed. The concentrations of both chrysotile and amphiboles in the first bronchoalveolar lavage (BAL) were related to their concentrations in the second BAL and the observed differences were not statistically significant. A significant decrease in asbestos body concentration between the first and the second BAL was found (Wilcoxon test, P < 0.01).
Conclusions: The reliability of the fibre concentration in BALF as a marker of past asbestos exposure seems quite good. In most cases, it allows us to distinguish workers in different classes of exposure and gives useful information on the pattern of exposure. Uncertainties related in general to lung residues and in particular to mineralogical analysis of BALF (mainly due to the high coefficient of variation (CV) at low fibre concentrations and the results of the statistical analysis on total fibres) suggest that this biomarker is more likely suitable for a qualitative/categorical approach to exposure assessment than a quantitative one.</description><subject>Adult</subject><subject>Aged</subject><subject>Asbestos - analysis</subject><subject>Bronchoalveolar Lavage Fluid</subject><subject>Bronchoscopy</subject><subject>Humans</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Mineral Fibers - analysis</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational Exposure - analysis</subject><subject>Reproducibility of Results</subject><issn>0003-4878</issn><issn>1475-3162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0MFLwzAUBvAgipvTo1fpSbzUJU3bJEctmwoTQRSP5bV53aptU5N2uP_ejk48PR7fjwfvI-SS0VtGFZ9D02x263mNNWXhEZmyUEQ-Z3FwTKaUUu6HUsgJOXPuc1hDrtgpmTARRnEk2ZRUzwiut1hj03mm8O5chq4zzluWmUUvMU0-JBa60jTOKxtvWfWl3stXbBE61N69NX6yMVBt0VRgvRVsYY1ubxY_rXED-TD2C607JycFVA4vDnNG3peLt-TRX708PCV3K98Egnd-AFpiLnWEIssZzUCoQkKAoAVTEMaxQqWjKNYhy5QqODKRqUyERQyFZLHkM3I93m2t-e6Hf9K6dDlWFTRoepcyJXgsJR3g1QH2WY06bW1Zg92lf_0M4GYEpm__U5ruq0_H6tOxev4LZnJ38w</recordid><startdate>200707</startdate><enddate>200707</enddate><creator>SARTORELLI, P</creator><creator>ROMEO, R</creator><creator>SCANCARELLO, G</creator><creator>MONTOMOLI, L</creator><creator>MUZZUPAPPA, C</creator><creator>BARABESI, L</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200707</creationdate><title>Measurement of Asbestos Fibre Concentrations in Fluid of Repeated Bro-Choalveolar Lavages of Exposed Workers</title><author>SARTORELLI, P ; ROMEO, R ; SCANCARELLO, G ; MONTOMOLI, L ; MUZZUPAPPA, C ; BARABESI, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-o273t-2ad8ec8d5e7bc10ba79f8a2ead719a4669e9d556d41b99f3e17b9b74f6af81683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Asbestos - analysis</topic><topic>Bronchoalveolar Lavage Fluid</topic><topic>Bronchoscopy</topic><topic>Humans</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Mineral Fibers - analysis</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational Exposure - analysis</topic><topic>Reproducibility of Results</topic><toplevel>online_resources</toplevel><creatorcontrib>SARTORELLI, P</creatorcontrib><creatorcontrib>ROMEO, R</creatorcontrib><creatorcontrib>SCANCARELLO, G</creatorcontrib><creatorcontrib>MONTOMOLI, L</creatorcontrib><creatorcontrib>MUZZUPAPPA, C</creatorcontrib><creatorcontrib>BARABESI, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>The Annals of occupational hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SARTORELLI, P</au><au>ROMEO, R</au><au>SCANCARELLO, G</au><au>MONTOMOLI, L</au><au>MUZZUPAPPA, C</au><au>BARABESI, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of Asbestos Fibre Concentrations in Fluid of Repeated Bro-Choalveolar Lavages of Exposed Workers</atitle><jtitle>The Annals of occupational hygiene</jtitle><addtitle>Ann Occup Hyg</addtitle><date>2007-07</date><risdate>2007</risdate><volume>51</volume><issue>5</issue><spage>495</spage><epage>500</epage><pages>495-500</pages><issn>0003-4878</issn><eissn>1475-3162</eissn><abstract>Objectives: The aim of this study was to assess the reliability of asbestos fibre concentration in bronchoalveolar lavage fluid (BALF) by carrying out the mineralogical analysis of BALF at different times in the same patient and comparing the results.
Methods: Twenty two patients underwent diagnostic fibreoptic bronchoscopy twice: the first was to assess the past asbestos exposure and the second for different clinical reasons. Mineralogical analysis of BALF was carried out.
Results: In 16 patients (72.7%), a reduction of concentration in BALF of all asbestos fibres was observed. The concentrations of both chrysotile and amphiboles in the first bronchoalveolar lavage (BAL) were related to their concentrations in the second BAL and the observed differences were not statistically significant. A significant decrease in asbestos body concentration between the first and the second BAL was found (Wilcoxon test, P < 0.01).
Conclusions: The reliability of the fibre concentration in BALF as a marker of past asbestos exposure seems quite good. In most cases, it allows us to distinguish workers in different classes of exposure and gives useful information on the pattern of exposure. Uncertainties related in general to lung residues and in particular to mineralogical analysis of BALF (mainly due to the high coefficient of variation (CV) at low fibre concentrations and the results of the statistical analysis on total fibres) suggest that this biomarker is more likely suitable for a qualitative/categorical approach to exposure assessment than a quantitative one.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>17456581</pmid><doi>10.1093/annhyg/mem014</doi><tpages>6</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Asbestos - analysis Bronchoalveolar Lavage Fluid Bronchoscopy Humans Male Microscopy, Electron Middle Aged Mineral Fibers - analysis Occupational Exposure - adverse effects Occupational Exposure - analysis Reproducibility of Results |
| title | Measurement of Asbestos Fibre Concentrations in Fluid of Repeated Bro-Choalveolar Lavages of Exposed Workers |
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