Paeoniflorin inhibits PDGF‑BB‑induced human airway smooth muscle cell growth and migration
Abnormal proliferation and migration of airway smooth muscle cells (ASMCs) is important in the progression of asthma. Paeoniflorin (PF), one of the major active ingredients of Paeonia lactiflora, has been reported to exhibit anti‑asthmatic effects. However, the effects of PF in the regulation of pla...
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| Veröffentlicht in: | Molecular medicine reports 2018-02, Vol.17 (2), p.2660-2664 |
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| creator | Zhou, Hong Wu, Qi Wei, Luqing Peng, Shouchun |
| description | Abnormal proliferation and migration of airway smooth muscle cells (ASMCs) is important in the progression of asthma. Paeoniflorin (PF), one of the major active ingredients of Paeonia lactiflora, has been reported to exhibit anti‑asthmatic effects. However, the effects of PF in the regulation of platelet‑derived growth factor (PDGF)‑BB‑induced ASMC proliferation and migration remain unknown. The present study was designed to investigate the effects of PF on human ASMCs and the underlying mechanism. The results demonstrated that PF treatment significantly reduced the numbers of live ASMC cells and their PDGF‑BB‑induced migration. PF treatment also suppressed PDGF‑BB‑induced α‑smooth muscle actin expression in ASMCs. Furthermore, pretreatment with PF reduced PDGF‑BB‑induced phosphorylation of phosphoinositide 3‑kinase (PI3K) and AKT serine/threonine kinase 1 (Akt) in ASMCs. In conclusion, the present study demonstrated for the first time that PF inhibited ASMC growth and migration induced by PDGF‑BB, and that this effect may be partly due to inhibition of the PI3K/Akt signaling pathway. The results provide novel information regarding the role of PF as a potential therapeutic agent for the treatment of asthma. |
| doi_str_mv | 10.3892/mmr.2017.8180 |
| format | Article |
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Paeoniflorin (PF), one of the major active ingredients of Paeonia lactiflora, has been reported to exhibit anti‑asthmatic effects. However, the effects of PF in the regulation of platelet‑derived growth factor (PDGF)‑BB‑induced ASMC proliferation and migration remain unknown. The present study was designed to investigate the effects of PF on human ASMCs and the underlying mechanism. The results demonstrated that PF treatment significantly reduced the numbers of live ASMC cells and their PDGF‑BB‑induced migration. PF treatment also suppressed PDGF‑BB‑induced α‑smooth muscle actin expression in ASMCs. Furthermore, pretreatment with PF reduced PDGF‑BB‑induced phosphorylation of phosphoinositide 3‑kinase (PI3K) and AKT serine/threonine kinase 1 (Akt) in ASMCs. In conclusion, the present study demonstrated for the first time that PF inhibited ASMC growth and migration induced by PDGF‑BB, and that this effect may be partly due to inhibition of the PI3K/Akt signaling pathway. The results provide novel information regarding the role of PF as a potential therapeutic agent for the treatment of asthma.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2017.8180</identifier><identifier>PMID: 29207148</identifier><language>eng</language><publisher>Greece: Spandidos Publications UK Ltd</publisher><subject>1-Phosphatidylinositol 3-kinase ; Actin ; AKT protein ; Asthma ; Biotechnology ; Cell cycle ; Cell growth ; Cell migration ; Cell proliferation ; Growth factors ; Kinases ; Membranes ; Pathogenesis ; Phosphorylation ; Platelet-derived growth factor ; Platelet-derived growth factor BB ; Protein-serine/threonine kinase ; Proteins ; Respiratory tract ; Signal transduction ; Smooth muscle ; Studies</subject><ispartof>Molecular medicine reports, 2018-02, Vol.17 (2), p.2660-2664</ispartof><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-f17121389e456429e9b9a2eeaf59d3c690ff4edee8feaa9aeb2b67aac014a9123</citedby><cites>FETCH-LOGICAL-c360t-f17121389e456429e9b9a2eeaf59d3c690ff4edee8feaa9aeb2b67aac014a9123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29207148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Hong</creatorcontrib><creatorcontrib>Wu, Qi</creatorcontrib><creatorcontrib>Wei, Luqing</creatorcontrib><creatorcontrib>Peng, Shouchun</creatorcontrib><title>Paeoniflorin inhibits PDGF‑BB‑induced human airway smooth muscle cell growth and migration</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Abnormal proliferation and migration of airway smooth muscle cells (ASMCs) is important in the progression of asthma. Paeoniflorin (PF), one of the major active ingredients of Paeonia lactiflora, has been reported to exhibit anti‑asthmatic effects. However, the effects of PF in the regulation of platelet‑derived growth factor (PDGF)‑BB‑induced ASMC proliferation and migration remain unknown. The present study was designed to investigate the effects of PF on human ASMCs and the underlying mechanism. The results demonstrated that PF treatment significantly reduced the numbers of live ASMC cells and their PDGF‑BB‑induced migration. PF treatment also suppressed PDGF‑BB‑induced α‑smooth muscle actin expression in ASMCs. Furthermore, pretreatment with PF reduced PDGF‑BB‑induced phosphorylation of phosphoinositide 3‑kinase (PI3K) and AKT serine/threonine kinase 1 (Akt) in ASMCs. In conclusion, the present study demonstrated for the first time that PF inhibited ASMC growth and migration induced by PDGF‑BB, and that this effect may be partly due to inhibition of the PI3K/Akt signaling pathway. The results provide novel information regarding the role of PF as a potential therapeutic agent for the treatment of asthma.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>Actin</subject><subject>AKT protein</subject><subject>Asthma</subject><subject>Biotechnology</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Cell migration</subject><subject>Cell proliferation</subject><subject>Growth factors</subject><subject>Kinases</subject><subject>Membranes</subject><subject>Pathogenesis</subject><subject>Phosphorylation</subject><subject>Platelet-derived growth factor</subject><subject>Platelet-derived growth factor BB</subject><subject>Protein-serine/threonine kinase</subject><subject>Proteins</subject><subject>Respiratory tract</subject><subject>Signal transduction</subject><subject>Smooth muscle</subject><subject>Studies</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkM1O3TAQRi0EAkpZdltZYtNNLrbj_MyyQC-thAQLuiWaJBOuUWyDnQix6yv0FfskdXQvXXRhezQ6-vT5MPZJilVegzq3NqyUkNWqlrXYY8eyApnlQuj93awAqiP2IcYnIcpCFXDIjhQoUUldH7OHOyTvzDD6YBw3bmNaM0V-d3W9_vPr98VFuozr5456vpktOo4mvOIbj9b7acPtHLuReEfjyB-Df00rdD235jHgZLz7yA4GHCOd7t4T9nP97f7ye3Zze_3j8utN1uWlmLJBVlLJ9B_SRakVELSAigiHAvq8K0EMg6aeqB4IEZBa1ZYVYiekRpAqP2FftrnPwb_MFKfGmri0Qkd-jo2EKtdFOnVCz_5Dn_wcXGqXKBBaFwBLYLaluuBjDDQ0z8FYDG-NFM0ivknim0V8s4hP_Odd6txa6v_R76bzv04VgS8</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Zhou, Hong</creator><creator>Wu, Qi</creator><creator>Wei, Luqing</creator><creator>Peng, Shouchun</creator><general>Spandidos Publications UK Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180201</creationdate><title>Paeoniflorin inhibits PDGF‑BB‑induced human airway smooth muscle cell growth and migration</title><author>Zhou, Hong ; Wu, Qi ; Wei, Luqing ; Peng, Shouchun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-f17121389e456429e9b9a2eeaf59d3c690ff4edee8feaa9aeb2b67aac014a9123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>Actin</topic><topic>AKT protein</topic><topic>Asthma</topic><topic>Biotechnology</topic><topic>Cell cycle</topic><topic>Cell growth</topic><topic>Cell migration</topic><topic>Cell proliferation</topic><topic>Growth factors</topic><topic>Kinases</topic><topic>Membranes</topic><topic>Pathogenesis</topic><topic>Phosphorylation</topic><topic>Platelet-derived growth factor</topic><topic>Platelet-derived growth factor BB</topic><topic>Protein-serine/threonine kinase</topic><topic>Proteins</topic><topic>Respiratory tract</topic><topic>Signal transduction</topic><topic>Smooth muscle</topic><topic>Studies</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Hong</creatorcontrib><creatorcontrib>Wu, Qi</creatorcontrib><creatorcontrib>Wei, Luqing</creatorcontrib><creatorcontrib>Peng, Shouchun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Hong</au><au>Wu, Qi</au><au>Wei, Luqing</au><au>Peng, Shouchun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paeoniflorin inhibits PDGF‑BB‑induced human airway smooth muscle cell growth and migration</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>17</volume><issue>2</issue><spage>2660</spage><epage>2664</epage><pages>2660-2664</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>Abnormal proliferation and migration of airway smooth muscle cells (ASMCs) is important in the progression of asthma. Paeoniflorin (PF), one of the major active ingredients of Paeonia lactiflora, has been reported to exhibit anti‑asthmatic effects. However, the effects of PF in the regulation of platelet‑derived growth factor (PDGF)‑BB‑induced ASMC proliferation and migration remain unknown. The present study was designed to investigate the effects of PF on human ASMCs and the underlying mechanism. The results demonstrated that PF treatment significantly reduced the numbers of live ASMC cells and their PDGF‑BB‑induced migration. PF treatment also suppressed PDGF‑BB‑induced α‑smooth muscle actin expression in ASMCs. Furthermore, pretreatment with PF reduced PDGF‑BB‑induced phosphorylation of phosphoinositide 3‑kinase (PI3K) and AKT serine/threonine kinase 1 (Akt) in ASMCs. In conclusion, the present study demonstrated for the first time that PF inhibited ASMC growth and migration induced by PDGF‑BB, and that this effect may be partly due to inhibition of the PI3K/Akt signaling pathway. The results provide novel information regarding the role of PF as a potential therapeutic agent for the treatment of asthma.</abstract><cop>Greece</cop><pub>Spandidos Publications UK Ltd</pub><pmid>29207148</pmid><doi>10.3892/mmr.2017.8180</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase Actin AKT protein Asthma Biotechnology Cell cycle Cell growth Cell migration Cell proliferation Growth factors Kinases Membranes Pathogenesis Phosphorylation Platelet-derived growth factor Platelet-derived growth factor BB Protein-serine/threonine kinase Proteins Respiratory tract Signal transduction Smooth muscle Studies |
| title | Paeoniflorin inhibits PDGF‑BB‑induced human airway smooth muscle cell growth and migration |
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