Low-protein diet supplemented with ketoacids delays the progression of diabetic nephropathy by inhibiting oxidative stress in the KKAy mice model
Diabetic nephropathy (DN) is a major cause of chronic kidney disease. We aimed to investigate the effect of the low-protein diets (LPD) supplemented with ketoacids (LPD+KA) in KKAy mice, an early type 2 DN model. KKAy mice were treated with normal protein diet (NPD), LPD or LPD+KA from 12 to 24 week...
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| Veröffentlicht in: | British journal of nutrition 2018-01, Vol.119 (1), p.22-29 |
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| creator | Liu, Dongmei Wu, Ming Li, Lin Gao, Xiang Yang, Bo Mei, Shuqin Fu, Lili Mei, Changlin |
| description | Diabetic nephropathy (DN) is a major cause of chronic kidney disease. We aimed to investigate the effect of the low-protein diets (LPD) supplemented with ketoacids (LPD+KA) in KKAy mice, an early type 2 DN model. KKAy mice were treated with normal protein diet (NPD), LPD or LPD+KA from 12 to 24 weeks of age. A period of 12-week treatment with LPD significantly reduced albuminuria as compared with that observed after NPD treatment. Treatment with LPD+KA further reduced albuminuria as compared with that observed with LPD treatment alone. Moreover, LPD treatment reduced mesangial expansion, thickness of glomerular basement membrane and the severity of the podocyte foot process effacement in KKAy mice; these effects were more pronounced in KKAy mice treated with LPD+KA. Both LPD and LPD+KA treatments slightly reduced total body weight, but had no significant effect on kidney weight and blood glucose concentrations when compared with NPD-treated KKAy mice. LPD treatment slightly attenuated oxidative stress in kidneys as compared with that observed in NPD-treated KKAy mice; however, LPD+KA treatment remarkably ameliorated oxidative stress in diabetic kidneys as shown by decreased malondialdehyde concentrations, protein carbonylation, nitrotyrosine expression and increased superoxide dismutase expression. Nutritional therapy using LPD+KA confers additional renal benefits as compared with those of LPD treatment alone in early type 2 DN through inhibition of oxidative stress. |
| doi_str_mv | 10.1017/S0007114517003208 |
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We aimed to investigate the effect of the low-protein diets (LPD) supplemented with ketoacids (LPD+KA) in KKAy mice, an early type 2 DN model. KKAy mice were treated with normal protein diet (NPD), LPD or LPD+KA from 12 to 24 weeks of age. A period of 12-week treatment with LPD significantly reduced albuminuria as compared with that observed after NPD treatment. Treatment with LPD+KA further reduced albuminuria as compared with that observed with LPD treatment alone. Moreover, LPD treatment reduced mesangial expansion, thickness of glomerular basement membrane and the severity of the podocyte foot process effacement in KKAy mice; these effects were more pronounced in KKAy mice treated with LPD+KA. Both LPD and LPD+KA treatments slightly reduced total body weight, but had no significant effect on kidney weight and blood glucose concentrations when compared with NPD-treated KKAy mice. LPD treatment slightly attenuated oxidative stress in kidneys as compared with that observed in NPD-treated KKAy mice; however, LPD+KA treatment remarkably ameliorated oxidative stress in diabetic kidneys as shown by decreased malondialdehyde concentrations, protein carbonylation, nitrotyrosine expression and increased superoxide dismutase expression. Nutritional therapy using LPD+KA confers additional renal benefits as compared with those of LPD treatment alone in early type 2 DN through inhibition of oxidative stress.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114517003208</identifier><identifier>PMID: 29208058</identifier><language>eng</language><publisher>England: Cambridge University Press</publisher><subject>Amino acids ; Antioxidants ; Body weight ; Carbonyls ; Diabetes ; Diabetes mellitus ; Diabetic nephropathy ; Diet ; Insulin resistance ; Kidney diseases ; Kidneys ; Laboratory animals ; Low protein diet ; Malondialdehyde ; Metabolism ; Mice ; Nephropathy ; Nitrotyrosine ; Nutrient deficiency ; Nutrition research ; Nutrition therapy ; Oxidative stress ; Proteins ; Rodents ; Superoxide dismutase ; Urine ; Weight reduction</subject><ispartof>British journal of nutrition, 2018-01, Vol.119 (1), p.22-29</ispartof><rights>Copyright © The Authors 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-836e81dc0c90701769f901fa63c526f97ef9708e0f01744dbca409a6f9b91d273</citedby><cites>FETCH-LOGICAL-c420t-836e81dc0c90701769f901fa63c526f97ef9708e0f01744dbca409a6f9b91d273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29208058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Dongmei</creatorcontrib><creatorcontrib>Wu, Ming</creatorcontrib><creatorcontrib>Li, Lin</creatorcontrib><creatorcontrib>Gao, Xiang</creatorcontrib><creatorcontrib>Yang, Bo</creatorcontrib><creatorcontrib>Mei, Shuqin</creatorcontrib><creatorcontrib>Fu, Lili</creatorcontrib><creatorcontrib>Mei, Changlin</creatorcontrib><title>Low-protein diet supplemented with ketoacids delays the progression of diabetic nephropathy by inhibiting oxidative stress in the KKAy mice model</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Diabetic nephropathy (DN) is a major cause of chronic kidney disease. We aimed to investigate the effect of the low-protein diets (LPD) supplemented with ketoacids (LPD+KA) in KKAy mice, an early type 2 DN model. KKAy mice were treated with normal protein diet (NPD), LPD or LPD+KA from 12 to 24 weeks of age. A period of 12-week treatment with LPD significantly reduced albuminuria as compared with that observed after NPD treatment. Treatment with LPD+KA further reduced albuminuria as compared with that observed with LPD treatment alone. Moreover, LPD treatment reduced mesangial expansion, thickness of glomerular basement membrane and the severity of the podocyte foot process effacement in KKAy mice; these effects were more pronounced in KKAy mice treated with LPD+KA. Both LPD and LPD+KA treatments slightly reduced total body weight, but had no significant effect on kidney weight and blood glucose concentrations when compared with NPD-treated KKAy mice. LPD treatment slightly attenuated oxidative stress in kidneys as compared with that observed in NPD-treated KKAy mice; however, LPD+KA treatment remarkably ameliorated oxidative stress in diabetic kidneys as shown by decreased malondialdehyde concentrations, protein carbonylation, nitrotyrosine expression and increased superoxide dismutase expression. Nutritional therapy using LPD+KA confers additional renal benefits as compared with those of LPD treatment alone in early type 2 DN through inhibition of oxidative stress.</description><subject>Amino acids</subject><subject>Antioxidants</subject><subject>Body weight</subject><subject>Carbonyls</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetic nephropathy</subject><subject>Diet</subject><subject>Insulin resistance</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Laboratory animals</subject><subject>Low protein diet</subject><subject>Malondialdehyde</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Nephropathy</subject><subject>Nitrotyrosine</subject><subject>Nutrient deficiency</subject><subject>Nutrition research</subject><subject>Nutrition therapy</subject><subject>Oxidative stress</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Superoxide 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diet supplemented with ketoacids delays the progression of diabetic nephropathy by inhibiting oxidative stress in the KKAy mice model</title><author>Liu, Dongmei ; Wu, Ming ; Li, Lin ; Gao, Xiang ; Yang, Bo ; Mei, Shuqin ; Fu, Lili ; Mei, Changlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-836e81dc0c90701769f901fa63c526f97ef9708e0f01744dbca409a6f9b91d273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Amino acids</topic><topic>Antioxidants</topic><topic>Body weight</topic><topic>Carbonyls</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetic nephropathy</topic><topic>Diet</topic><topic>Insulin resistance</topic><topic>Kidney diseases</topic><topic>Kidneys</topic><topic>Laboratory animals</topic><topic>Low protein 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Changlin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-protein diet supplemented with ketoacids delays the progression of diabetic nephropathy by inhibiting oxidative stress in the KKAy mice model</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2018-01-14</date><risdate>2018</risdate><volume>119</volume><issue>1</issue><spage>22</spage><epage>29</epage><pages>22-29</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>Diabetic nephropathy (DN) is a major cause of chronic kidney disease. We aimed to investigate the effect of the low-protein diets (LPD) supplemented with ketoacids (LPD+KA) in KKAy mice, an early type 2 DN model. KKAy mice were treated with normal protein diet (NPD), LPD or LPD+KA from 12 to 24 weeks of age. A period of 12-week treatment with LPD significantly reduced albuminuria as compared with that observed after NPD treatment. Treatment with LPD+KA further reduced albuminuria as compared with that observed with LPD treatment alone. Moreover, LPD treatment reduced mesangial expansion, thickness of glomerular basement membrane and the severity of the podocyte foot process effacement in KKAy mice; these effects were more pronounced in KKAy mice treated with LPD+KA. Both LPD and LPD+KA treatments slightly reduced total body weight, but had no significant effect on kidney weight and blood glucose concentrations when compared with NPD-treated KKAy mice. LPD treatment slightly attenuated oxidative stress in kidneys as compared with that observed in NPD-treated KKAy mice; however, LPD+KA treatment remarkably ameliorated oxidative stress in diabetic kidneys as shown by decreased malondialdehyde concentrations, protein carbonylation, nitrotyrosine expression and increased superoxide dismutase expression. Nutritional therapy using LPD+KA confers additional renal benefits as compared with those of LPD treatment alone in early type 2 DN through inhibition of oxidative stress.</abstract><cop>England</cop><pub>Cambridge University Press</pub><pmid>29208058</pmid><doi>10.1017/S0007114517003208</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino acids Antioxidants Body weight Carbonyls Diabetes Diabetes mellitus Diabetic nephropathy Diet Insulin resistance Kidney diseases Kidneys Laboratory animals Low protein diet Malondialdehyde Metabolism Mice Nephropathy Nitrotyrosine Nutrient deficiency Nutrition research Nutrition therapy Oxidative stress Proteins Rodents Superoxide dismutase Urine Weight reduction |
| title | Low-protein diet supplemented with ketoacids delays the progression of diabetic nephropathy by inhibiting oxidative stress in the KKAy mice model |
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