Caenorhabditis elegans: nature and nurture gift to nematode parasitologists
The free-living nematode Caenorhabditis elegans is the simplest animal model organism to work with. Substantial knowledge and tools have accumulated over 50 years of C. elegans research. The use of C. elegans relating to parasitic nematodes from a basic biology standpoint or an applied perspective h...
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| Veröffentlicht in: | Parasitology 2018-07, Vol.145 (8), p.979-987 |
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| creator | Salinas, Gustavo Risi, Gastón |
| description | The free-living nematode Caenorhabditis elegans is the simplest animal model organism to work with. Substantial knowledge and tools have accumulated over 50 years of C. elegans research. The use of C. elegans relating to parasitic nematodes from a basic biology standpoint or an applied perspective has increased in recent years. The wealth of information gained on the model organism, the use of the powerful approaches and technologies that have advanced C. elegans research to parasitic nematodes and the enormous success of the omics fields have contributed to bridge the divide between C. elegans and parasite nematode researchers. We review key fields, such as genomics, drug discovery and genetics, where C. elegans and nematode parasite research have convened. We advocate the use of C. elegans as a model to study helminth metabolism, a neglected area ready to advance. How emerging technologies being used in C. elegans can pave the way for parasitic nematode research is discussed. |
| doi_str_mv | 10.1017/S0031182017002165 |
| format | Article |
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| issn | 0031-1820 1469-8161 |
| language | eng |
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| source | Cambridge University Press Journals Complete |
| subjects | Animal models Biology Biosynthesis Caenorhabditis elegans Genes Genetic engineering Genetics Genomics Laboratories Metabolism Metabolites Nematodes Nervous system Parasites Parasitology Researchers Studies Worms |
| title | Caenorhabditis elegans: nature and nurture gift to nematode parasitologists |
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