ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation

Array-based comparative genomic hybridization (CGH-array) has a powerful potential for high-throughput identification of genetic aberrations in cell genomes. We identified a homozygous loss of ADAM23 (2q33.3) in the course of a program to screen a panel of gastric cancer (GC) cell lines (1/32, 3.1%)...

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Veröffentlicht in:	Oncogene 2005-12, Vol.24 (54), p.8051-8060
Hauptverfasser:	Takada, Hisashi, Imoto, Issei, Tsuda, Hitoshi, Nakanishi, Yukihiro, Ichikura, Takashi, Mochizuki, Hidetaka, Mitsufuji, Shoji, Hosoda, Fumie, Hirohashi, Setsuo, Ohki, Misao, Inazawa, Johji
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - genetics Apoptosis Biological and medical sciences Carcinogenesis Cell Biology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosome aberrations Clonal deletion CpG Islands DNA Methylation Epigenetics Fundamental and applied biological sciences. Psychology Gastric cancer Gastroenterology. Liver. Pancreas. Abdomen Gene Deletion Gene expression Gene Expression Regulation, Neoplastic Gene Silencing Genes, Tumor Suppressor Genomics Human Genetics Humans Hybridization Internal Medicine Medical genetics Medical sciences Medicine Medicine & Public Health Molecular and cellular biology mRNA Nucleic Acid Hybridization Oncology original-paper Promoter Regions, Genetic Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumor cell lines Tumor suppressor genes Tumors
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