ILEI: A cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells

Erk/MAPK and TGFβ signaling cause epithelial to mesenchymal transition (EMT) and metastasis in mouse mammary epithelial cells (EpH4) transformed with oncogenic Ras (EpRas). In trials to unravel underlying mechanisms, expression profiling for EMT-specific genes identified a secreted interleukin-relat...

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Veröffentlicht in:	Cancer cell 2006-09, Vol.10 (3), p.227-239
Hauptverfasser:	Waerner, Thomas, Alacakaptan, Memetcan, Tamir, Ido, Oberauer, Rupert, Gal, Annamaria, Brabletz, Thomas, Schreiber, Martin, Jechlinger, Martin, Beug, Hartmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cell Line Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology CELLBIO Cytokines - genetics Cytokines - metabolism Epithelial Cells - metabolism Epithelial Cells - pathology Gene Expression Regulation, Neoplastic Humans Mesenchymal Stromal Cells - cytology Mice Mice, Inbred BALB C Neoplasm Metastasis - pathology Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasm Transplantation Neoplasms - metabolism Neoplasms - pathology Prognosis Protein Biosynthesis - genetics RNA Interference RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Survival Rate Time Factors Transforming Growth Factor beta - metabolism
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