Local gene therapy of solid tumors with GM-CSF and B7-1 eradicates both treated and distal tumors

Gene therapy-induced expression of immunostimulatory molecules at tumor cell level may evoke antitumor immune mechanisms by recruiting and enhancing viability of antigen-processing cells and specific tumoricidal lymphocytes. The antitumor efficacy of a plasmid, coding for granulocyte–macrophage colo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer gene therapy 2006-12, Vol.13 (12), p.1061-1071
Hauptverfasser:	Collins, C G, Tangney, M, Larkin, J O, Casey, G, Whelan, M C, Cashman, J, Murphy, J, Soden, D, Vejda, S, McKenna, S, Kiely, B, Collins, J K, Barrett, J, Aarons, S, O'Sullivan, G C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen presenting cells Antigen processing Antitumor activity B7-1 Antigen - genetics Biomedical and Life Sciences Biomedicine Care and treatment CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor - pathology Cell Transplantation Colony-stimulating factor Cytotoxicity Tests, Immunologic Electroporation Electroporation - instrumentation Electroporation - methods Female Fibrosarcoma - genetics Fibrosarcoma - immunology Fibrosarcoma - pathology Fibrosarcoma - therapy Gene Expression Gene Therapy Genetic aspects Genetic Therapy - methods Genetic Vectors - genetics Genetic Vectors - immunology Genetic Vectors - pharmacology Granulocyte-macrophage colony stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - genetics Health aspects Immunostimulation Liver Neoplasms - pathology Liver Neoplasms - secondary Liver Neoplasms - therapy Lymphocytes Lymphocytes - immunology Metastases Metastasis Methods Mice Mice, Nude original-article Plasmids - genetics Solid tumors Transfection Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!