Complement activation in vitro and reactogenicity of low-molecular weight dextran-coated SPIONs in the pig CARPA model: Correlation with physicochemical features and clinical information

The unique magnetic properties of superparamagnetic iron oxide nanoparticles (SPIONs) have led to their increasing use in drug delivery and imaging applications. Some polymer-coated SPIONs, however, share with many other nanoparticles the potential of causing hypersensitivity reactions (HSRs) known...

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Veröffentlicht in:	Journal of controlled release 2018-01, Vol.270, p.268-274
Hauptverfasser:	Fülöp, Tamás, Nemes, Réka, Mészáros, Tamás, Urbanics, Rudolf, Kok, Robbert Jan, Jackman, Joshua A., Cho, Nam-Joon, Storm, Gert, Szebeni, János
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphylatoxins Anaphylaxis CARPA Complement Hypersensitivity reactions Imaging Immune toxicity Iron MRI Nanomedicines Nanoparticles
Online-Zugang:	Volltext
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