Assessing the influence of isoflurane anesthesia on cardiac metabolism using hyperpolarized [1‐13C]pyruvate

Isoflurane is a frequently used anesthetic in small‐animal dissolution dynamic nuclear polarization‐magnetic resonance imaging (DNP‐MRI) studies. Although the literature suggests interactions with mitochondrial metabolism, the influence of the compound on cardiac metabolism has not been assessed sys...

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Veröffentlicht in:	NMR in biomedicine 2018-02, Vol.31 (2), p.n/a
Hauptverfasser:	Steinhauser, Jonas, Wespi, Patrick, Kwiatkowski, Grzegorz, Kozerke, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - metabolism Anesthesia Animals Area Under Curve Bicarbonates Bicarbonates - metabolism Biological products Carbon Isotopes - metabolism Carbonates cardiac metabolism Heart Heart diseases hyperpolarized [1‐13C]pyruvate Isoflurane Isoflurane - pharmacology Lactic acid Magnetic resonance imaging Male metabolic imaging Metabolism Metabolome - drug effects Mitochondria Myocardium - metabolism NMR Nuclear magnetic resonance Pyruvic acid Pyruvic Acid - metabolism Rats Rats, Wistar
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