Foot‐and‐mouth disease virus transmission dynamics and persistence in a herd of vaccinated dairy cattle in India
Summary Foot‐and‐mouth disease (FMD) is an important transboundary disease with substantial economic impacts. Although between‐herd transmission of the disease has been well studied, studies focusing on within‐herd transmission using farm‐level outbreak data are rare. The aim of this study was to es...
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| Veröffentlicht in: | Transboundary and emerging diseases 2018-04, Vol.65 (2), p.e404-e415 |
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| creator | Hayer, S. S. VanderWaal, K. Ranjan, R. Biswal, J. K. Subramaniam, S. Mohapatra, J. K. Sharma, G. K. Rout, M. Dash, B. B. Das, B. Prusty, B. R. Sharma, A. K. Stenfeldt, C. Perez, A. Delgado, A. H. Sharma, M. K. Rodriguez, L. L. Pattnaik, B. Arzt, J. |
| description | Summary
Foot‐and‐mouth disease (FMD) is an important transboundary disease with substantial economic impacts. Although between‐herd transmission of the disease has been well studied, studies focusing on within‐herd transmission using farm‐level outbreak data are rare. The aim of this study was to estimate parameters associated with within‐herd transmission, host physiological factors and FMD virus (FMDV) persistence using data collected from an outbreak that occurred at a large, organized dairy farm in India. Of 1,836 regularly vaccinated, adult dairy cattle, 222 had clinical signs of FMD over a 39‐day period. Assuming homogenous mixing, a frequency‐dependent compartmental model of disease transmission was built. The transmission coefficient and basic reproductive number were estimated to be between 16.2–18.4 and 67–88, respectively. Non‐pregnant animals were more likely to manifest clinical signs of FMD as compared to pregnant cattle. Based on oropharyngeal fluid (probang) sampling and FMDV‐specific RT‐PCR, four of 36 longitudinally sampled animals (14%) were persistently infected carriers 10.5 months post‐outbreak. There was no statistical difference between subclinical and clinically infected animals in the duration of the carrier state. However, prevalence of NSP‐ELISA antibodies differed significantly between subclinical and clinically infected animals 12 months after the outbreak with 83% seroprevalence amongst clinically infected cattle compared to 69% of subclinical animals. This study further elucidates within‐herd FMD transmission dynamics during the acute‐phase and characterizes duration of FMDV persistence and seroprevalence of FMD under natural conditions in an endemic setting. |
| doi_str_mv | 10.1111/tbed.12774 |
| format | Article |
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Foot‐and‐mouth disease (FMD) is an important transboundary disease with substantial economic impacts. Although between‐herd transmission of the disease has been well studied, studies focusing on within‐herd transmission using farm‐level outbreak data are rare. The aim of this study was to estimate parameters associated with within‐herd transmission, host physiological factors and FMD virus (FMDV) persistence using data collected from an outbreak that occurred at a large, organized dairy farm in India. Of 1,836 regularly vaccinated, adult dairy cattle, 222 had clinical signs of FMD over a 39‐day period. Assuming homogenous mixing, a frequency‐dependent compartmental model of disease transmission was built. The transmission coefficient and basic reproductive number were estimated to be between 16.2–18.4 and 67–88, respectively. Non‐pregnant animals were more likely to manifest clinical signs of FMD as compared to pregnant cattle. Based on oropharyngeal fluid (probang) sampling and FMDV‐specific RT‐PCR, four of 36 longitudinally sampled animals (14%) were persistently infected carriers 10.5 months post‐outbreak. There was no statistical difference between subclinical and clinically infected animals in the duration of the carrier state. However, prevalence of NSP‐ELISA antibodies differed significantly between subclinical and clinically infected animals 12 months after the outbreak with 83% seroprevalence amongst clinically infected cattle compared to 69% of subclinical animals. This study further elucidates within‐herd FMD transmission dynamics during the acute‐phase and characterizes duration of FMDV persistence and seroprevalence of FMD under natural conditions in an endemic setting.</description><identifier>ISSN: 1865-1674</identifier><identifier>EISSN: 1865-1682</identifier><identifier>DOI: 10.1111/tbed.12774</identifier><identifier>PMID: 29205858</identifier><language>eng</language><publisher>Germany: Hindawi Limited</publisher><subject>Animals ; Antibodies ; Antibodies, Viral - blood ; Carrier State - veterinary ; Cattle ; Cattle Diseases - epidemiology ; Cattle Diseases - prevention & control ; Cattle Diseases - transmission ; Dairy cattle ; Disease Outbreaks - veterinary ; Disease transmission ; Disease Transmission, Infectious - veterinary ; Economic impact ; Enzyme-linked immunosorbent assay ; Enzyme-Linked Immunosorbent Assay - veterinary ; epidemiological model ; Farms ; Female ; Foot & mouth disease ; Foot-and-Mouth Disease - epidemiology ; Foot-and-Mouth Disease - prevention & control ; Foot-and-Mouth Disease - transmission ; Foot-and-Mouth Disease Virus - immunology ; Foot-and-Mouth Disease Virus - isolation & purification ; foot‐and‐mouth disease ; foot‐and‐mouth diseases virus ; India ; Male ; Outbreaks ; Parameter estimation ; Physiological effects ; Physiological factors ; Pregnancy ; Prevalence ; Seroepidemiologic Studies ; Serology ; transmission coefficient ; Vaccination ; Vaccination - veterinary ; Viral Vaccines - administration & dosage ; Viruses</subject><ispartof>Transboundary and emerging diseases, 2018-04, Vol.65 (2), p.e404-e415</ispartof><rights>2017 Blackwell Verlag GmbH</rights><rights>2017 Blackwell Verlag GmbH.</rights><rights>Copyright © 2018 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3574-ac07bba36d3800ae6f750822004f88ce147533922f9ac52c61d170fa2708d2203</citedby><cites>FETCH-LOGICAL-c3574-ac07bba36d3800ae6f750822004f88ce147533922f9ac52c61d170fa2708d2203</cites><orcidid>0000-0001-9270-8900 ; 0000-0002-2074-3886 ; 0000-0002-7517-7893</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftbed.12774$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftbed.12774$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29205858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hayer, S. S.</creatorcontrib><creatorcontrib>VanderWaal, K.</creatorcontrib><creatorcontrib>Ranjan, R.</creatorcontrib><creatorcontrib>Biswal, J. K.</creatorcontrib><creatorcontrib>Subramaniam, S.</creatorcontrib><creatorcontrib>Mohapatra, J. K.</creatorcontrib><creatorcontrib>Sharma, G. K.</creatorcontrib><creatorcontrib>Rout, M.</creatorcontrib><creatorcontrib>Dash, B. B.</creatorcontrib><creatorcontrib>Das, B.</creatorcontrib><creatorcontrib>Prusty, B. R.</creatorcontrib><creatorcontrib>Sharma, A. K.</creatorcontrib><creatorcontrib>Stenfeldt, C.</creatorcontrib><creatorcontrib>Perez, A.</creatorcontrib><creatorcontrib>Delgado, A. H.</creatorcontrib><creatorcontrib>Sharma, M. K.</creatorcontrib><creatorcontrib>Rodriguez, L. L.</creatorcontrib><creatorcontrib>Pattnaik, B.</creatorcontrib><creatorcontrib>Arzt, J.</creatorcontrib><title>Foot‐and‐mouth disease virus transmission dynamics and persistence in a herd of vaccinated dairy cattle in India</title><title>Transboundary and emerging diseases</title><addtitle>Transbound Emerg Dis</addtitle><description>Summary
Foot‐and‐mouth disease (FMD) is an important transboundary disease with substantial economic impacts. Although between‐herd transmission of the disease has been well studied, studies focusing on within‐herd transmission using farm‐level outbreak data are rare. The aim of this study was to estimate parameters associated with within‐herd transmission, host physiological factors and FMD virus (FMDV) persistence using data collected from an outbreak that occurred at a large, organized dairy farm in India. Of 1,836 regularly vaccinated, adult dairy cattle, 222 had clinical signs of FMD over a 39‐day period. Assuming homogenous mixing, a frequency‐dependent compartmental model of disease transmission was built. The transmission coefficient and basic reproductive number were estimated to be between 16.2–18.4 and 67–88, respectively. Non‐pregnant animals were more likely to manifest clinical signs of FMD as compared to pregnant cattle. Based on oropharyngeal fluid (probang) sampling and FMDV‐specific RT‐PCR, four of 36 longitudinally sampled animals (14%) were persistently infected carriers 10.5 months post‐outbreak. There was no statistical difference between subclinical and clinically infected animals in the duration of the carrier state. However, prevalence of NSP‐ELISA antibodies differed significantly between subclinical and clinically infected animals 12 months after the outbreak with 83% seroprevalence amongst clinically infected cattle compared to 69% of subclinical animals. This study further elucidates within‐herd FMD transmission dynamics during the acute‐phase and characterizes duration of FMDV persistence and seroprevalence of FMD under natural conditions in an endemic setting.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Carrier State - veterinary</subject><subject>Cattle</subject><subject>Cattle Diseases - epidemiology</subject><subject>Cattle Diseases - prevention & control</subject><subject>Cattle Diseases - transmission</subject><subject>Dairy cattle</subject><subject>Disease Outbreaks - veterinary</subject><subject>Disease transmission</subject><subject>Disease Transmission, Infectious - veterinary</subject><subject>Economic impact</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzyme-Linked Immunosorbent Assay - veterinary</subject><subject>epidemiological model</subject><subject>Farms</subject><subject>Female</subject><subject>Foot & mouth disease</subject><subject>Foot-and-Mouth Disease - epidemiology</subject><subject>Foot-and-Mouth Disease - prevention & control</subject><subject>Foot-and-Mouth Disease - transmission</subject><subject>Foot-and-Mouth Disease Virus - immunology</subject><subject>Foot-and-Mouth Disease Virus - isolation & purification</subject><subject>foot‐and‐mouth disease</subject><subject>foot‐and‐mouth diseases virus</subject><subject>India</subject><subject>Male</subject><subject>Outbreaks</subject><subject>Parameter estimation</subject><subject>Physiological effects</subject><subject>Physiological factors</subject><subject>Pregnancy</subject><subject>Prevalence</subject><subject>Seroepidemiologic Studies</subject><subject>Serology</subject><subject>transmission coefficient</subject><subject>Vaccination</subject><subject>Vaccination - veterinary</subject><subject>Viral Vaccines - administration & dosage</subject><subject>Viruses</subject><issn>1865-1674</issn><issn>1865-1682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90cFuFSEUBmBibGytbnwAQ-LGmNz2wMDALLW22qRJN3VNzgUmpZmBKzBt7s5H8Bl9Emlv68JFWQAhX_4DHELeMThibRzXtXdHjCslXpADpnu5Yr3mL__tldgnr0u5Aehh6OUrss8HDlJLfUDqWUr1z6_fGF2b57TUa-pC8Vg8vQ15KbRmjGUOpYQUqdtGnIMttHm68bmEUn20noZIkV777Gga6S1aGyJW76jDkLfUYq3TAzqPLuAbsjfiVPzbx_WQ_Dg7vTr5vrq4_HZ-8vliZTupxAotqPUau951GgB9PyoJmnMAMWptPRNKdt3A-Tigldz2zDEFI3IF2jXWHZKPu9xNTj8XX6pp77B-mjD6tBTDBtUBFyD6Rj_8R2_SkmO7nWn1BsFBSNHUp52yOZWS_Wg2OcyYt4aBue-Fue-FeehFw-8fI5f13E6f6NPnN8B24C5MfvtMlLn6cvp1F_oXJ_OVlw</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Hayer, S. S.</creator><creator>VanderWaal, K.</creator><creator>Ranjan, R.</creator><creator>Biswal, J. K.</creator><creator>Subramaniam, S.</creator><creator>Mohapatra, J. K.</creator><creator>Sharma, G. K.</creator><creator>Rout, M.</creator><creator>Dash, B. B.</creator><creator>Das, B.</creator><creator>Prusty, B. R.</creator><creator>Sharma, A. K.</creator><creator>Stenfeldt, C.</creator><creator>Perez, A.</creator><creator>Delgado, A. H.</creator><creator>Sharma, M. K.</creator><creator>Rodriguez, L. L.</creator><creator>Pattnaik, B.</creator><creator>Arzt, J.</creator><general>Hindawi Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9270-8900</orcidid><orcidid>https://orcid.org/0000-0002-2074-3886</orcidid><orcidid>https://orcid.org/0000-0002-7517-7893</orcidid></search><sort><creationdate>201804</creationdate><title>Foot‐and‐mouth disease virus transmission dynamics and persistence in a herd of vaccinated dairy cattle in India</title><author>Hayer, S. S. ; VanderWaal, K. ; Ranjan, R. ; Biswal, J. K. ; Subramaniam, S. ; Mohapatra, J. K. ; Sharma, G. K. ; Rout, M. ; Dash, B. B. ; Das, B. ; Prusty, B. R. ; Sharma, A. K. ; Stenfeldt, C. ; Perez, A. ; Delgado, A. H. ; Sharma, M. K. ; Rodriguez, L. L. ; Pattnaik, B. ; Arzt, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3574-ac07bba36d3800ae6f750822004f88ce147533922f9ac52c61d170fa2708d2203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Viral - blood</topic><topic>Carrier State - veterinary</topic><topic>Cattle</topic><topic>Cattle Diseases - epidemiology</topic><topic>Cattle Diseases - prevention & control</topic><topic>Cattle Diseases - transmission</topic><topic>Dairy cattle</topic><topic>Disease Outbreaks - veterinary</topic><topic>Disease transmission</topic><topic>Disease Transmission, Infectious - veterinary</topic><topic>Economic impact</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzyme-Linked Immunosorbent Assay - veterinary</topic><topic>epidemiological model</topic><topic>Farms</topic><topic>Female</topic><topic>Foot & mouth disease</topic><topic>Foot-and-Mouth Disease - epidemiology</topic><topic>Foot-and-Mouth Disease - prevention & control</topic><topic>Foot-and-Mouth Disease - transmission</topic><topic>Foot-and-Mouth Disease Virus - immunology</topic><topic>Foot-and-Mouth Disease Virus - isolation & purification</topic><topic>foot‐and‐mouth disease</topic><topic>foot‐and‐mouth diseases virus</topic><topic>India</topic><topic>Male</topic><topic>Outbreaks</topic><topic>Parameter estimation</topic><topic>Physiological effects</topic><topic>Physiological factors</topic><topic>Pregnancy</topic><topic>Prevalence</topic><topic>Seroepidemiologic Studies</topic><topic>Serology</topic><topic>transmission coefficient</topic><topic>Vaccination</topic><topic>Vaccination - veterinary</topic><topic>Viral Vaccines - administration & dosage</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hayer, S. S.</creatorcontrib><creatorcontrib>VanderWaal, K.</creatorcontrib><creatorcontrib>Ranjan, R.</creatorcontrib><creatorcontrib>Biswal, J. K.</creatorcontrib><creatorcontrib>Subramaniam, S.</creatorcontrib><creatorcontrib>Mohapatra, J. K.</creatorcontrib><creatorcontrib>Sharma, G. K.</creatorcontrib><creatorcontrib>Rout, M.</creatorcontrib><creatorcontrib>Dash, B. B.</creatorcontrib><creatorcontrib>Das, B.</creatorcontrib><creatorcontrib>Prusty, B. R.</creatorcontrib><creatorcontrib>Sharma, A. K.</creatorcontrib><creatorcontrib>Stenfeldt, C.</creatorcontrib><creatorcontrib>Perez, A.</creatorcontrib><creatorcontrib>Delgado, A. H.</creatorcontrib><creatorcontrib>Sharma, M. K.</creatorcontrib><creatorcontrib>Rodriguez, L. L.</creatorcontrib><creatorcontrib>Pattnaik, B.</creatorcontrib><creatorcontrib>Arzt, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transboundary and emerging diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hayer, S. S.</au><au>VanderWaal, K.</au><au>Ranjan, R.</au><au>Biswal, J. K.</au><au>Subramaniam, S.</au><au>Mohapatra, J. K.</au><au>Sharma, G. K.</au><au>Rout, M.</au><au>Dash, B. B.</au><au>Das, B.</au><au>Prusty, B. R.</au><au>Sharma, A. K.</au><au>Stenfeldt, C.</au><au>Perez, A.</au><au>Delgado, A. H.</au><au>Sharma, M. K.</au><au>Rodriguez, L. L.</au><au>Pattnaik, B.</au><au>Arzt, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Foot‐and‐mouth disease virus transmission dynamics and persistence in a herd of vaccinated dairy cattle in India</atitle><jtitle>Transboundary and emerging diseases</jtitle><addtitle>Transbound Emerg Dis</addtitle><date>2018-04</date><risdate>2018</risdate><volume>65</volume><issue>2</issue><spage>e404</spage><epage>e415</epage><pages>e404-e415</pages><issn>1865-1674</issn><eissn>1865-1682</eissn><abstract>Summary
Foot‐and‐mouth disease (FMD) is an important transboundary disease with substantial economic impacts. Although between‐herd transmission of the disease has been well studied, studies focusing on within‐herd transmission using farm‐level outbreak data are rare. The aim of this study was to estimate parameters associated with within‐herd transmission, host physiological factors and FMD virus (FMDV) persistence using data collected from an outbreak that occurred at a large, organized dairy farm in India. Of 1,836 regularly vaccinated, adult dairy cattle, 222 had clinical signs of FMD over a 39‐day period. Assuming homogenous mixing, a frequency‐dependent compartmental model of disease transmission was built. The transmission coefficient and basic reproductive number were estimated to be between 16.2–18.4 and 67–88, respectively. Non‐pregnant animals were more likely to manifest clinical signs of FMD as compared to pregnant cattle. Based on oropharyngeal fluid (probang) sampling and FMDV‐specific RT‐PCR, four of 36 longitudinally sampled animals (14%) were persistently infected carriers 10.5 months post‐outbreak. There was no statistical difference between subclinical and clinically infected animals in the duration of the carrier state. However, prevalence of NSP‐ELISA antibodies differed significantly between subclinical and clinically infected animals 12 months after the outbreak with 83% seroprevalence amongst clinically infected cattle compared to 69% of subclinical animals. This study further elucidates within‐herd FMD transmission dynamics during the acute‐phase and characterizes duration of FMDV persistence and seroprevalence of FMD under natural conditions in an endemic setting.</abstract><cop>Germany</cop><pub>Hindawi Limited</pub><pmid>29205858</pmid><doi>10.1111/tbed.12774</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-9270-8900</orcidid><orcidid>https://orcid.org/0000-0002-2074-3886</orcidid><orcidid>https://orcid.org/0000-0002-7517-7893</orcidid></addata></record> |
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| ispartof | Transboundary and emerging diseases, 2018-04, Vol.65 (2), p.e404-e415 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals Antibodies Antibodies, Viral - blood Carrier State - veterinary Cattle Cattle Diseases - epidemiology Cattle Diseases - prevention & control Cattle Diseases - transmission Dairy cattle Disease Outbreaks - veterinary Disease transmission Disease Transmission, Infectious - veterinary Economic impact Enzyme-linked immunosorbent assay Enzyme-Linked Immunosorbent Assay - veterinary epidemiological model Farms Female Foot & mouth disease Foot-and-Mouth Disease - epidemiology Foot-and-Mouth Disease - prevention & control Foot-and-Mouth Disease - transmission Foot-and-Mouth Disease Virus - immunology Foot-and-Mouth Disease Virus - isolation & purification foot‐and‐mouth disease foot‐and‐mouth diseases virus India Male Outbreaks Parameter estimation Physiological effects Physiological factors Pregnancy Prevalence Seroepidemiologic Studies Serology transmission coefficient Vaccination Vaccination - veterinary Viral Vaccines - administration & dosage Viruses |
| title | Foot‐and‐mouth disease virus transmission dynamics and persistence in a herd of vaccinated dairy cattle in India |
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