Improved rectal dosimetry with the use of SpaceOAR during high-dose-rate brachytherapy
Hydrogel spacers have been suggested to limit rectal radiation dose with improvements in clinical outcomes in patients undergoing external beam radiation treatment for prostate cancer. No studies to date have assessed the utility and dosimetric effect of SpaceOAR (Augmenix, Inc, Waltham, MA), the on...
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| Veröffentlicht in: | Brachytherapy 2018-03, Vol.17 (2), p.259-264 |
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| creator | Wu, Susan Y. Boreta, Lauren Wu, Ashley Cheung, Joey P. Cunha, J. Adam M. Shinohara, Katsuto Chang, Albert J. |
| description | Hydrogel spacers have been suggested to limit rectal radiation dose with improvements in clinical outcomes in patients undergoing external beam radiation treatment for prostate cancer. No studies to date have assessed the utility and dosimetric effect of SpaceOAR (Augmenix, Inc, Waltham, MA), the only Food and Drug Administration–approved hydrogel rectal spacer, for high-dose-rate (HDR) brachytherapy.
Eighteen consecutive patients scheduled for HDR brachytherapy in the treatment of prostate cancer underwent transperineal ultrasound-guided placement of 10 cc of SpaceOAR hydrogel following catheter implantation. Treatment plans were generated using an inverse planning simulated annealing algorithm. Rectal dosimetry for these 18 patients was compared with the 36 preceding patients treated with HDR brachytherapy without SpaceOAR.
Fifty-four plans were analyzed. There was no difference in age, pretreatment prostate-specific antigen, Gleason score, clinical stage, prostate volume, or contoured rectal volume between those who received SpaceOAR and those who did not. Patients who received SpaceOAR hydrogel had significantly lower dose to the rectum as measured by percent of contoured organ at risk (median, V80 |
| doi_str_mv | 10.1016/j.brachy.2017.10.014 |
| format | Article |
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Eighteen consecutive patients scheduled for HDR brachytherapy in the treatment of prostate cancer underwent transperineal ultrasound-guided placement of 10 cc of SpaceOAR hydrogel following catheter implantation. Treatment plans were generated using an inverse planning simulated annealing algorithm. Rectal dosimetry for these 18 patients was compared with the 36 preceding patients treated with HDR brachytherapy without SpaceOAR.
Fifty-four plans were analyzed. There was no difference in age, pretreatment prostate-specific antigen, Gleason score, clinical stage, prostate volume, or contoured rectal volume between those who received SpaceOAR and those who did not. Patients who received SpaceOAR hydrogel had significantly lower dose to the rectum as measured by percent of contoured organ at risk (median, V80 < 0.005% vs. 0.010%, p = 0.003; V75 < 0.005% vs. 0.14%, p < 0.0005; V70 0.09% vs. 0.88%, p < 0.0005; V60 = 1.16% vs. 3.08%, p < 0.0005); similar results were seen for rectal volume in cubic centimeters. One patient who received SpaceOAR developed a perineal abscess 1 month after treatment.
Transperineal insertion of SpaceOAR hydrogel at the time of HDR brachytherapy is feasible and decreases rectal radiation dose. Further investigation is needed to assess the clinical impact of this dosimetric improvement and potential toxicity reduction.</description><identifier>ISSN: 1538-4721</identifier><identifier>EISSN: 1873-1449</identifier><identifier>DOI: 10.1016/j.brachy.2017.10.014</identifier><identifier>PMID: 29203149</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Brachytherapy ; Dosimetry ; Hydrogel ; Prostate cancer ; Rectal protection</subject><ispartof>Brachytherapy, 2018-03, Vol.17 (2), p.259-264</ispartof><rights>2017</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-9f1cc7650e9f20414d1b3b4d13c1d2b7a0f9702e2b7a6b9762d9761076be7c843</citedby><cites>FETCH-LOGICAL-c362t-9f1cc7650e9f20414d1b3b4d13c1d2b7a0f9702e2b7a6b9762d9761076be7c843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.brachy.2017.10.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29203149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Susan Y.</creatorcontrib><creatorcontrib>Boreta, Lauren</creatorcontrib><creatorcontrib>Wu, Ashley</creatorcontrib><creatorcontrib>Cheung, Joey P.</creatorcontrib><creatorcontrib>Cunha, J. Adam M.</creatorcontrib><creatorcontrib>Shinohara, Katsuto</creatorcontrib><creatorcontrib>Chang, Albert J.</creatorcontrib><title>Improved rectal dosimetry with the use of SpaceOAR during high-dose-rate brachytherapy</title><title>Brachytherapy</title><addtitle>Brachytherapy</addtitle><description>Hydrogel spacers have been suggested to limit rectal radiation dose with improvements in clinical outcomes in patients undergoing external beam radiation treatment for prostate cancer. No studies to date have assessed the utility and dosimetric effect of SpaceOAR (Augmenix, Inc, Waltham, MA), the only Food and Drug Administration–approved hydrogel rectal spacer, for high-dose-rate (HDR) brachytherapy.
Eighteen consecutive patients scheduled for HDR brachytherapy in the treatment of prostate cancer underwent transperineal ultrasound-guided placement of 10 cc of SpaceOAR hydrogel following catheter implantation. Treatment plans were generated using an inverse planning simulated annealing algorithm. Rectal dosimetry for these 18 patients was compared with the 36 preceding patients treated with HDR brachytherapy without SpaceOAR.
Fifty-four plans were analyzed. There was no difference in age, pretreatment prostate-specific antigen, Gleason score, clinical stage, prostate volume, or contoured rectal volume between those who received SpaceOAR and those who did not. Patients who received SpaceOAR hydrogel had significantly lower dose to the rectum as measured by percent of contoured organ at risk (median, V80 < 0.005% vs. 0.010%, p = 0.003; V75 < 0.005% vs. 0.14%, p < 0.0005; V70 0.09% vs. 0.88%, p < 0.0005; V60 = 1.16% vs. 3.08%, p < 0.0005); similar results were seen for rectal volume in cubic centimeters. One patient who received SpaceOAR developed a perineal abscess 1 month after treatment.
Transperineal insertion of SpaceOAR hydrogel at the time of HDR brachytherapy is feasible and decreases rectal radiation dose. Further investigation is needed to assess the clinical impact of this dosimetric improvement and potential toxicity reduction.</description><subject>Brachytherapy</subject><subject>Dosimetry</subject><subject>Hydrogel</subject><subject>Prostate cancer</subject><subject>Rectal protection</subject><issn>1538-4721</issn><issn>1873-1449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE9P4zAQxS0EArbLN0ArH7mkeGwT15eVEGJ3K1WqxJ-9Wo49Ia6aptgJq357HIXlyGU8Gv2eZ94j5BLYHBiU15t5Fa1rDnPOQOXRnIE8IuewUKIAKfVx7m_EopCKwxn5ltKGZZkW4pSccc2ZAKnPyd9lu4_dG3oa0fV2S32XQot9PNB_oW9o3yAdEtKupo9763B9-0D9EMPuhTbhpSkyjkW0PdLpmsxHuz98Jye13Sa8-Hhn5PnX_dPdn2K1_r28u10VTpS8L3QNzqnyhqGuOZMgPVSiylU48LxSltVaMY5jW1ZaldznAkyVFSq3kGJGrqZ_s4nXAVNv2pAcbrd2h92QDGglGBfAFxmVE-pil1LE2uxjaG08GGBmTNRszOTBjImO05xolv342DBULfpP0f8IM_BzAjD7fAsYTXIBdw59GCM1vgtfb3gHbhWI1Q</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Wu, Susan Y.</creator><creator>Boreta, Lauren</creator><creator>Wu, Ashley</creator><creator>Cheung, Joey P.</creator><creator>Cunha, J. Adam M.</creator><creator>Shinohara, Katsuto</creator><creator>Chang, Albert J.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201803</creationdate><title>Improved rectal dosimetry with the use of SpaceOAR during high-dose-rate brachytherapy</title><author>Wu, Susan Y. ; Boreta, Lauren ; Wu, Ashley ; Cheung, Joey P. ; Cunha, J. Adam M. ; Shinohara, Katsuto ; Chang, Albert J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-9f1cc7650e9f20414d1b3b4d13c1d2b7a0f9702e2b7a6b9762d9761076be7c843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Brachytherapy</topic><topic>Dosimetry</topic><topic>Hydrogel</topic><topic>Prostate cancer</topic><topic>Rectal protection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Susan Y.</creatorcontrib><creatorcontrib>Boreta, Lauren</creatorcontrib><creatorcontrib>Wu, Ashley</creatorcontrib><creatorcontrib>Cheung, Joey P.</creatorcontrib><creatorcontrib>Cunha, J. Adam M.</creatorcontrib><creatorcontrib>Shinohara, Katsuto</creatorcontrib><creatorcontrib>Chang, Albert J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brachytherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Susan Y.</au><au>Boreta, Lauren</au><au>Wu, Ashley</au><au>Cheung, Joey P.</au><au>Cunha, J. Adam M.</au><au>Shinohara, Katsuto</au><au>Chang, Albert J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved rectal dosimetry with the use of SpaceOAR during high-dose-rate brachytherapy</atitle><jtitle>Brachytherapy</jtitle><addtitle>Brachytherapy</addtitle><date>2018-03</date><risdate>2018</risdate><volume>17</volume><issue>2</issue><spage>259</spage><epage>264</epage><pages>259-264</pages><issn>1538-4721</issn><eissn>1873-1449</eissn><abstract>Hydrogel spacers have been suggested to limit rectal radiation dose with improvements in clinical outcomes in patients undergoing external beam radiation treatment for prostate cancer. No studies to date have assessed the utility and dosimetric effect of SpaceOAR (Augmenix, Inc, Waltham, MA), the only Food and Drug Administration–approved hydrogel rectal spacer, for high-dose-rate (HDR) brachytherapy.
Eighteen consecutive patients scheduled for HDR brachytherapy in the treatment of prostate cancer underwent transperineal ultrasound-guided placement of 10 cc of SpaceOAR hydrogel following catheter implantation. Treatment plans were generated using an inverse planning simulated annealing algorithm. Rectal dosimetry for these 18 patients was compared with the 36 preceding patients treated with HDR brachytherapy without SpaceOAR.
Fifty-four plans were analyzed. There was no difference in age, pretreatment prostate-specific antigen, Gleason score, clinical stage, prostate volume, or contoured rectal volume between those who received SpaceOAR and those who did not. Patients who received SpaceOAR hydrogel had significantly lower dose to the rectum as measured by percent of contoured organ at risk (median, V80 < 0.005% vs. 0.010%, p = 0.003; V75 < 0.005% vs. 0.14%, p < 0.0005; V70 0.09% vs. 0.88%, p < 0.0005; V60 = 1.16% vs. 3.08%, p < 0.0005); similar results were seen for rectal volume in cubic centimeters. One patient who received SpaceOAR developed a perineal abscess 1 month after treatment.
Transperineal insertion of SpaceOAR hydrogel at the time of HDR brachytherapy is feasible and decreases rectal radiation dose. Further investigation is needed to assess the clinical impact of this dosimetric improvement and potential toxicity reduction.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29203149</pmid><doi>10.1016/j.brachy.2017.10.014</doi><tpages>6</tpages></addata></record> |
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| subjects | Brachytherapy Dosimetry Hydrogel Prostate cancer Rectal protection |
| title | Improved rectal dosimetry with the use of SpaceOAR during high-dose-rate brachytherapy |
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