Modulation of the functional binding sites for TGF- on the type II receptor leads to suppression of TGF- signaling

Transforming growth factor-beta (TGF-beta) binds to two different types of serine/threonine kinase receptors termed type II (TbetaR-II) and type I (TbetaR-I). TGF-beta is unable to bind to TbetaR-I in the absence of TbetaR-II, and initiates receptor assembly by binding with high affinity to TbetaR-I...

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Veröffentlicht in:	Oncogene 2007-05, Vol.26 (23), p.3311-3320
Hauptverfasser:	Shimanuki, T, Hara, T, Furuya, T, Imamura, T, Miyazono, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Binding sites Cancer Genetics Kinases Mutation Signal transduction
Online-Zugang:	Volltext
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