Cables links Robo-bound Abl kinase to N-cadherin-bound [beta]-catenin to mediate Slit-induced modulation of adhesion and transcription

Binding of the secreted axon guidance cue Slit to its Robo receptor results in inactivation of the neural, calcium-dependent cell-cell adhesion molecule N-cadherin, providing a rapid epigenetic mechanism for integrating guidance and adhesion information. This requires the formation of a multimolecul...

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Veröffentlicht in:	Nature cell biology 2007-08, Vol.9 (8), p.883-892
Hauptverfasser:	Rhee, Jinseol, Buchan, Tim, Zukerberg, Lawrence, Lilien, Jack, Balsamo, Janne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Antibodies Cables Calcium Inactivation Kinases Peptides Phosphorylation Retina
Online-Zugang:	Volltext
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