Antidepressant combinations: epidemiological considerations
Objective: To evaluate the treatment options in patients who do not respond appropriately to a single antidepressant alone. Method: The medical literature was reviewed. Results: A number of strategies are available if a patient fails to respond adequately to initial antidepressant treatment, incl...
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| Veröffentlicht in: | Acta psychiatrica Scandinavica 2005-11, Vol.112 (s428), p.7-10 |
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| container_issue | s428 |
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| container_title | Acta psychiatrica Scandinavica |
| container_volume | 112 |
| creator | Agüera, L. F. Rojo, J. E. Ros, S. de la Gándara, J. de Pedro, J. M. |
| description | Objective: To evaluate the treatment options in patients who do not respond appropriately to a single antidepressant alone.
Method: The medical literature was reviewed.
Results: A number of strategies are available if a patient fails to respond adequately to initial antidepressant treatment, including the combination with another psychoactive drug. Evidence published to date appears to suggest that benzodiazepines are the drugs most frequently combined with antidepressants. The combination of two antidepressants together is less common, occurring in approximately 5–15% of cases showing a poor initial response. The key figures involved in such co‐prescription are psychiatrists.
Conclusion: There appears to be considerable variability in the data concerning combined prescription of antidepressants, with differences arising depending on the type of physician, the type of patient or illness and the geographical area. It is also unclear how closely research findings parallel with what doctors do in everyday practice. |
| doi_str_mv | 10.1111/j.1600-0447.2005.00674.x |
| format | Article |
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Method: The medical literature was reviewed.
Results: A number of strategies are available if a patient fails to respond adequately to initial antidepressant treatment, including the combination with another psychoactive drug. Evidence published to date appears to suggest that benzodiazepines are the drugs most frequently combined with antidepressants. The combination of two antidepressants together is less common, occurring in approximately 5–15% of cases showing a poor initial response. The key figures involved in such co‐prescription are psychiatrists.
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Method: The medical literature was reviewed.
Results: A number of strategies are available if a patient fails to respond adequately to initial antidepressant treatment, including the combination with another psychoactive drug. Evidence published to date appears to suggest that benzodiazepines are the drugs most frequently combined with antidepressants. The combination of two antidepressants together is less common, occurring in approximately 5–15% of cases showing a poor initial response. The key figures involved in such co‐prescription are psychiatrists.
Conclusion: There appears to be considerable variability in the data concerning combined prescription of antidepressants, with differences arising depending on the type of physician, the type of patient or illness and the geographical area. It is also unclear how closely research findings parallel with what doctors do in everyday practice.</description><subject>antidepressants</subject><subject>Antidepressive Agents - administration & dosage</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Benzodiazepines - administration & dosage</subject><subject>Benzodiazepines - therapeutic use</subject><subject>Cross-Cultural Comparison</subject><subject>depression</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - psychology</subject><subject>Drug Administration Schedule</subject><subject>drug combinations</subject><subject>Drug Resistance</subject><subject>Drug Therapy, Combination</subject><subject>Drug Utilization</subject><subject>epidemiology</subject><subject>Humans</subject><subject>Pharmacoepidemiology - statistics & numerical data</subject><subject>Practice Patterns, Physicians</subject><subject>Psychiatry - statistics & numerical data</subject><subject>Psychotropic Drugs - administration & dosage</subject><subject>Psychotropic Drugs - therapeutic use</subject><subject>Research Design</subject><issn>0001-690X</issn><issn>0065-1591</issn><issn>1600-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0EouXxC6grdgkzTWLHIBZVBQUJ8SwCsbEcM0EueZQ4FeXvcUkFW7ywx3PvnZEOYwOEEP05moXIAQKIYxEOAZIQgIs4XG6w_q-wyfoAgAGX8NxjO87N_DdBSLdZD3kEgmPcZyejqrWvNG_IOV21A1OXma10a-vKHQ9o7rXS1kX9Zo0uvFo532k6fY9t5bpwtL9-d9nj-dl0fBFc3Uwux6OrwMQpj_1NOQFJQwmATDTEWQJICDzPTWZEmgotZEQoh2iAa5lqMukwk0mWEWZxtMsOu7nzpv5YkGtVaZ2hotAV1QunUIqhlIjemHZG09TONZSreWNL3XwpBLUCp2ZqxUet-KgVOPUDTi199GC9Y5GV9PoXXJPyhtPO8GkL-vr3YDUa3z74yueDLm9dS8vfvG7eFReRSNTT9URdT-_uUcCLktE3s6qMNw</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>Agüera, L. F.</creator><creator>Rojo, J. E.</creator><creator>Ros, S.</creator><creator>de la Gándara, J.</creator><creator>de Pedro, J. M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>200511</creationdate><title>Antidepressant combinations: epidemiological considerations</title><author>Agüera, L. F. ; Rojo, J. E. ; Ros, S. ; de la Gándara, J. ; de Pedro, J. 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F.</creatorcontrib><creatorcontrib>Rojo, J. E.</creatorcontrib><creatorcontrib>Ros, S.</creatorcontrib><creatorcontrib>de la Gándara, J.</creatorcontrib><creatorcontrib>de Pedro, J. M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Acta psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agüera, L. F.</au><au>Rojo, J. E.</au><au>Ros, S.</au><au>de la Gándara, J.</au><au>de Pedro, J. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antidepressant combinations: epidemiological considerations</atitle><jtitle>Acta psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand Suppl</addtitle><date>2005-11</date><risdate>2005</risdate><volume>112</volume><issue>s428</issue><spage>7</spage><epage>10</epage><pages>7-10</pages><issn>0001-690X</issn><issn>0065-1591</issn><eissn>1600-0447</eissn><abstract>Objective: To evaluate the treatment options in patients who do not respond appropriately to a single antidepressant alone.
Method: The medical literature was reviewed.
Results: A number of strategies are available if a patient fails to respond adequately to initial antidepressant treatment, including the combination with another psychoactive drug. Evidence published to date appears to suggest that benzodiazepines are the drugs most frequently combined with antidepressants. The combination of two antidepressants together is less common, occurring in approximately 5–15% of cases showing a poor initial response. The key figures involved in such co‐prescription are psychiatrists.
Conclusion: There appears to be considerable variability in the data concerning combined prescription of antidepressants, with differences arising depending on the type of physician, the type of patient or illness and the geographical area. It is also unclear how closely research findings parallel with what doctors do in everyday practice.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16307614</pmid><doi>10.1111/j.1600-0447.2005.00674.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | antidepressants Antidepressive Agents - administration & dosage Antidepressive Agents - therapeutic use Benzodiazepines - administration & dosage Benzodiazepines - therapeutic use Cross-Cultural Comparison depression Depressive Disorder - drug therapy Depressive Disorder - psychology Drug Administration Schedule drug combinations Drug Resistance Drug Therapy, Combination Drug Utilization epidemiology Humans Pharmacoepidemiology - statistics & numerical data Practice Patterns, Physicians Psychiatry - statistics & numerical data Psychotropic Drugs - administration & dosage Psychotropic Drugs - therapeutic use Research Design |
| title | Antidepressant combinations: epidemiological considerations |
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