Polybrominated diphenyl ethers (PBDEs) in grey seals during their first year of life—are they thyroid hormone endocrine disrupters?
Results are consistent with a link between thyroid hormones and exposure to PBDEs in grey seal pups. Blubber biopsy and blood samples were collected from weaned grey seal pups and juveniles in 1998 and 1999. The relationship between the concentration of total PDBEs in the blubber and the circulating...
Gespeichert in:
| Veröffentlicht in: | Environmental pollution (1987) 2003-01, Vol.126 (1), p.29-37 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 37 |
|---|---|
| container_issue | 1 |
| container_start_page | 29 |
| container_title | Environmental pollution (1987) |
| container_volume | 126 |
| creator | Hall, Ailsa J. Kalantzi, Olga I. Thomas, Gareth O. |
| description | Results are consistent with a link between thyroid hormones and exposure to PBDEs in grey seal pups.
Blubber biopsy and blood samples were collected from weaned grey seal pups and juveniles in 1998 and 1999. The relationship between the concentration of total PDBEs in the blubber and the circulating concentrations of serum proteins, minerals and thyroid hormones was investigated. Fifty-four post-weaned pups were sampled and 55 first year juveniles, of which 13 were recaptured post-weaned pups. The median concentration of total PBDEs in the pups’ blubber was 170 and 460 ng g
−1 in the first-year animals. Total blubber PBDEs contributed significantly to the prediction of circulating thyroid hormone concentrations, after controlling for age and condition. Cholesterol and albumin concentrations were also positively related to blubber PBDEs. The results of this study suggest a link between thyroid hormones and exposure to PBDEs in grey seals during their first year of life. Such an association is not alone sufficient evidence for a cause and effect relationship, however it is in accordance with the hypothesis that these compounds are endocrine disrupters in grey seal pups. |
| doi_str_mv | 10.1016/S0269-7491(03)00149-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_19729872</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0269749103001490</els_id><sourcerecordid>19729872</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-60bc9bb173860eac5aa053d3e52ec68bfcecb05d4edce62fe3928b739f8388db3</originalsourceid><addsrcrecordid>eNqFkM9u1DAQhy0EosvCI4B8oWoPKeM4_3yqoBSoVIlKwNly7EnXKImXcVIpNy68AU_Ik-DtruiRy3gkfzO_0cfYSwFnAkT15gvklcrqQokTkKcAolAZPGIr0dQyq4q8eMxW_5Aj9izG7wBQSCmfsiORNxUIgBX7dRP6paUw-NFM6Ljz2w2OS89x2iBFfnLz7v1lPOV-5LeEC49o-sjdTH685QnxxDtPceILGuKh473v8M_P34Zw972kslDwjm8CDWFEjqMLNk1jioo0b6eUcv6cPenSXnxxeNfs24fLrxefsuvPH68u3l5ntqiLKaugtaptRS3T-WhsaQyU0kksc7RV03YWbQulK9BZrPIOpcqbtpaqa2TTuFau2fF-75bCjxnjpAcfLfa9GTHMUQtV56qp8wSWe9BSiJGw01vyg6FFC9A7__rev97J1SD1vf_UrNmrQ8DcDugepg7CE_D6AJhoTd-RGa2PD1yhZFODStz5nsOk484j6Wg9jhadJ7STdsH_55S_N82l3w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19729872</pqid></control><display><type>article</type><title>Polybrominated diphenyl ethers (PBDEs) in grey seals during their first year of life—are they thyroid hormone endocrine disrupters?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Hall, Ailsa J. ; Kalantzi, Olga I. ; Thomas, Gareth O.</creator><creatorcontrib>Hall, Ailsa J. ; Kalantzi, Olga I. ; Thomas, Gareth O.</creatorcontrib><description>Results are consistent with a link between thyroid hormones and exposure to PBDEs in grey seal pups.
Blubber biopsy and blood samples were collected from weaned grey seal pups and juveniles in 1998 and 1999. The relationship between the concentration of total PDBEs in the blubber and the circulating concentrations of serum proteins, minerals and thyroid hormones was investigated. Fifty-four post-weaned pups were sampled and 55 first year juveniles, of which 13 were recaptured post-weaned pups. The median concentration of total PBDEs in the pups’ blubber was 170 and 460 ng g
−1 in the first-year animals. Total blubber PBDEs contributed significantly to the prediction of circulating thyroid hormone concentrations, after controlling for age and condition. Cholesterol and albumin concentrations were also positively related to blubber PBDEs. The results of this study suggest a link between thyroid hormones and exposure to PBDEs in grey seals during their first year of life. Such an association is not alone sufficient evidence for a cause and effect relationship, however it is in accordance with the hypothesis that these compounds are endocrine disrupters in grey seal pups.</description><identifier>ISSN: 0269-7491</identifier><identifier>EISSN: 1873-6424</identifier><identifier>DOI: 10.1016/S0269-7491(03)00149-0</identifier><identifier>PMID: 12860100</identifier><identifier>CODEN: ENVPAF</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adipose Tissue - chemistry ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biological and medical sciences ; Cholesterol - blood ; Contaminants ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; endocrine disruptors ; Environmental Exposure ; Exposure ; Fundamental and applied biological sciences. Psychology ; Halichoerus grypus ; Hydrocarbons, Brominated - toxicity ; Mammalia ; Marine mammal ; Minerals - blood ; Phenyl Ethers - toxicity ; polybrominated diphenyl ethers ; Seals, Earless - physiology ; Seawater ; Serum Albumin - analysis ; Thyroid Hormones - blood ; Thyroid Hormones - physiology ; Water Pollutants, Chemical - toxicity</subject><ispartof>Environmental pollution (1987), 2003-01, Vol.126 (1), p.29-37</ispartof><rights>2003 Elsevier Science Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-60bc9bb173860eac5aa053d3e52ec68bfcecb05d4edce62fe3928b739f8388db3</citedby><cites>FETCH-LOGICAL-c474t-60bc9bb173860eac5aa053d3e52ec68bfcecb05d4edce62fe3928b739f8388db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0269749103001490$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14938709$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12860100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hall, Ailsa J.</creatorcontrib><creatorcontrib>Kalantzi, Olga I.</creatorcontrib><creatorcontrib>Thomas, Gareth O.</creatorcontrib><title>Polybrominated diphenyl ethers (PBDEs) in grey seals during their first year of life—are they thyroid hormone endocrine disrupters?</title><title>Environmental pollution (1987)</title><addtitle>Environ Pollut</addtitle><description>Results are consistent with a link between thyroid hormones and exposure to PBDEs in grey seal pups.
Blubber biopsy and blood samples were collected from weaned grey seal pups and juveniles in 1998 and 1999. The relationship between the concentration of total PDBEs in the blubber and the circulating concentrations of serum proteins, minerals and thyroid hormones was investigated. Fifty-four post-weaned pups were sampled and 55 first year juveniles, of which 13 were recaptured post-weaned pups. The median concentration of total PBDEs in the pups’ blubber was 170 and 460 ng g
−1 in the first-year animals. Total blubber PBDEs contributed significantly to the prediction of circulating thyroid hormone concentrations, after controlling for age and condition. Cholesterol and albumin concentrations were also positively related to blubber PBDEs. The results of this study suggest a link between thyroid hormones and exposure to PBDEs in grey seals during their first year of life. Such an association is not alone sufficient evidence for a cause and effect relationship, however it is in accordance with the hypothesis that these compounds are endocrine disrupters in grey seal pups.</description><subject>Adipose Tissue - chemistry</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Cholesterol - blood</subject><subject>Contaminants</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>endocrine disruptors</subject><subject>Environmental Exposure</subject><subject>Exposure</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Halichoerus grypus</subject><subject>Hydrocarbons, Brominated - toxicity</subject><subject>Mammalia</subject><subject>Marine mammal</subject><subject>Minerals - blood</subject><subject>Phenyl Ethers - toxicity</subject><subject>polybrominated diphenyl ethers</subject><subject>Seals, Earless - physiology</subject><subject>Seawater</subject><subject>Serum Albumin - analysis</subject><subject>Thyroid Hormones - blood</subject><subject>Thyroid Hormones - physiology</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>0269-7491</issn><issn>1873-6424</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9u1DAQhy0EosvCI4B8oWoPKeM4_3yqoBSoVIlKwNly7EnXKImXcVIpNy68AU_Ik-DtruiRy3gkfzO_0cfYSwFnAkT15gvklcrqQokTkKcAolAZPGIr0dQyq4q8eMxW_5Aj9izG7wBQSCmfsiORNxUIgBX7dRP6paUw-NFM6Ljz2w2OS89x2iBFfnLz7v1lPOV-5LeEC49o-sjdTH685QnxxDtPceILGuKh473v8M_P34Zw972kslDwjm8CDWFEjqMLNk1jioo0b6eUcv6cPenSXnxxeNfs24fLrxefsuvPH68u3l5ntqiLKaugtaptRS3T-WhsaQyU0kksc7RV03YWbQulK9BZrPIOpcqbtpaqa2TTuFau2fF-75bCjxnjpAcfLfa9GTHMUQtV56qp8wSWe9BSiJGw01vyg6FFC9A7__rev97J1SD1vf_UrNmrQ8DcDugepg7CE_D6AJhoTd-RGa2PD1yhZFODStz5nsOk484j6Wg9jhadJ7STdsH_55S_N82l3w</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Hall, Ailsa J.</creator><creator>Kalantzi, Olga I.</creator><creator>Thomas, Gareth O.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7SN</scope><scope>7TN</scope><scope>7TV</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20030101</creationdate><title>Polybrominated diphenyl ethers (PBDEs) in grey seals during their first year of life—are they thyroid hormone endocrine disrupters?</title><author>Hall, Ailsa J. ; Kalantzi, Olga I. ; Thomas, Gareth O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-60bc9bb173860eac5aa053d3e52ec68bfcecb05d4edce62fe3928b739f8388db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adipose Tissue - chemistry</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Cholesterol - blood</topic><topic>Contaminants</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>endocrine disruptors</topic><topic>Environmental Exposure</topic><topic>Exposure</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Halichoerus grypus</topic><topic>Hydrocarbons, Brominated - toxicity</topic><topic>Mammalia</topic><topic>Marine mammal</topic><topic>Minerals - blood</topic><topic>Phenyl Ethers - toxicity</topic><topic>polybrominated diphenyl ethers</topic><topic>Seals, Earless - physiology</topic><topic>Seawater</topic><topic>Serum Albumin - analysis</topic><topic>Thyroid Hormones - blood</topic><topic>Thyroid Hormones - physiology</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hall, Ailsa J.</creatorcontrib><creatorcontrib>Kalantzi, Olga I.</creatorcontrib><creatorcontrib>Thomas, Gareth O.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Ecology Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Environmental pollution (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hall, Ailsa J.</au><au>Kalantzi, Olga I.</au><au>Thomas, Gareth O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polybrominated diphenyl ethers (PBDEs) in grey seals during their first year of life—are they thyroid hormone endocrine disrupters?</atitle><jtitle>Environmental pollution (1987)</jtitle><addtitle>Environ Pollut</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>126</volume><issue>1</issue><spage>29</spage><epage>37</epage><pages>29-37</pages><issn>0269-7491</issn><eissn>1873-6424</eissn><coden>ENVPAF</coden><abstract>Results are consistent with a link between thyroid hormones and exposure to PBDEs in grey seal pups.
Blubber biopsy and blood samples were collected from weaned grey seal pups and juveniles in 1998 and 1999. The relationship between the concentration of total PDBEs in the blubber and the circulating concentrations of serum proteins, minerals and thyroid hormones was investigated. Fifty-four post-weaned pups were sampled and 55 first year juveniles, of which 13 were recaptured post-weaned pups. The median concentration of total PBDEs in the pups’ blubber was 170 and 460 ng g
−1 in the first-year animals. Total blubber PBDEs contributed significantly to the prediction of circulating thyroid hormone concentrations, after controlling for age and condition. Cholesterol and albumin concentrations were also positively related to blubber PBDEs. The results of this study suggest a link between thyroid hormones and exposure to PBDEs in grey seals during their first year of life. Such an association is not alone sufficient evidence for a cause and effect relationship, however it is in accordance with the hypothesis that these compounds are endocrine disrupters in grey seal pups.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12860100</pmid><doi>10.1016/S0269-7491(03)00149-0</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-7491 |
| ispartof | Environmental pollution (1987), 2003-01, Vol.126 (1), p.29-37 |
| issn | 0269-7491 1873-6424 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_19729872 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adipose Tissue - chemistry Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Cholesterol - blood Contaminants Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates endocrine disruptors Environmental Exposure Exposure Fundamental and applied biological sciences. Psychology Halichoerus grypus Hydrocarbons, Brominated - toxicity Mammalia Marine mammal Minerals - blood Phenyl Ethers - toxicity polybrominated diphenyl ethers Seals, Earless - physiology Seawater Serum Albumin - analysis Thyroid Hormones - blood Thyroid Hormones - physiology Water Pollutants, Chemical - toxicity |
| title | Polybrominated diphenyl ethers (PBDEs) in grey seals during their first year of life—are they thyroid hormone endocrine disrupters? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T00%3A31%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Polybrominated%20diphenyl%20ethers%20(PBDEs)%20in%20grey%20seals%20during%20their%20first%20year%20of%20life%E2%80%94are%20they%20thyroid%20hormone%20endocrine%20disrupters?&rft.jtitle=Environmental%20pollution%20(1987)&rft.au=Hall,%20Ailsa%20J.&rft.date=2003-01-01&rft.volume=126&rft.issue=1&rft.spage=29&rft.epage=37&rft.pages=29-37&rft.issn=0269-7491&rft.eissn=1873-6424&rft.coden=ENVPAF&rft_id=info:doi/10.1016/S0269-7491(03)00149-0&rft_dat=%3Cproquest_cross%3E19729872%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19729872&rft_id=info:pmid/12860100&rft_els_id=S0269749103001490&rfr_iscdi=true |