Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection

The early inflammatory response during reperfusion of cardiac allografts is initiated by the infiltration of polymorphonuclear leukocytes (PMNs) into the graft. The impact of early PMN infiltration on allograft rejection compared with long-term graft survival remains poorly understood. We tested the...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2005-07, Vol.112 (3), p.320-331
Hauptverfasser:	EL-SAWY, Tarek, BELPERIO, John A, STRIETER, Robert M, REMICK, Daniel G, FAIRCHILD, Robert L
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Animals Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system CD40 Ligand - physiology CD8-Positive T-Lymphocytes - immunology Cytokines - biosynthesis Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endothelial Cells - physiology Graft Rejection - prevention & control Graft Survival Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Heart Transplantation - immunology Immunoconjugates - pharmacology Immunologic Memory Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Neutrophil Infiltration Neutrophils - physiology Receptors, Interleukin-8B - antagonists & inhibitors Receptors, Interleukin-8B - physiology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Transplantation, Homologous
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