Evaluation of Circulating Intestinally Committed Memory B Cells in Children Vaccinated with Attenuated Human Rotavirus Vaccine
In a double blind trial, 319 fully immunized children received two doses of either placebo or 10 6.7 focus-forming units of the attenuated RIX4414 human rotavirus (RV) vaccine ("all-in-one" formulation). Plasma RV-specific IgA (RV IgA), stool RV IgA, and circulating total and RV memory B c...
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| Veröffentlicht in: | Viral Immunology 2007-06, Vol.20 (2), p.3-311 |
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| creator | Rojas, Olga Lucía Caicedo, Liliana Guzmán, Carolina Rodríguez, Luz-Stella Castañeda, Javier Uribe, Liliana Andrade, Yohanna Pinzón, Ricardo Narváez, Carlos Fernando Lozano, Juan Manuel De Vos, Beatrice Franco, Manuel A. Angel, Juana |
| description | In a double blind trial, 319 fully immunized children
received two doses of either placebo or 10
6.7
focus-forming units of the attenuated RIX4414 human rotavirus (RV) vaccine ("all-in-one" formulation). Plasma RV-specific IgA (RV IgA), stool RV IgA, and circulating total and RV memory B cells (CD19
+
IgD
+ −
CD27
+
) with an intestinal homing phenotype (α
4
β
7
+
CCR9
+ −
) were measured, after the first and second doses, as potential correlates of protection. After the first and or second dose, 54% of vaccinees and 13% of placebo recipients had plasma RV IgA. Before vaccination, most (95%) of the children (of both study groups) were breast-fed and had stool RV IgA (68.64%). Co-proconversion (4-fold increase) after the first and or second dose was observed in 32.7% of vaccinees and 17.4% of placebo recipients. No significant difference was seen when comparing the frequencies of any subset of memory B cells between vaccinees and placebo recipients. Statistically significant weak correlations were found between plasma RV IgA titers and coproconversion, and several subsets of memory B cells. The vaccine provided 74.8% protection (95% confidence interval, 30.93-92.62) against any RV gastroenteritis and 100% protection (95% confidence interval, 14.53-100) against severe RV gastroenteritis. When vaccinees and placebo recipients were considered together, a correlation was found between protection from disease and plasma RV IgA measured after dose 2 and RV memory (IgD
−
CD27
+
α
4
β
7
+
CCR9
+
) circulating B cells measured after dose 1. However, the correlation coefficients for both tests were low ( |
| doi_str_mv | 10.1089/vim.2006.0105 |
| format | Article |
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received two doses of either placebo or 10
6.7
focus-forming units of the attenuated RIX4414 human rotavirus (RV) vaccine ("all-in-one" formulation). Plasma RV-specific IgA (RV IgA), stool RV IgA, and circulating total and RV memory B cells (CD19
+
IgD
+ −
CD27
+
) with an intestinal homing phenotype (α
4
β
7
+
CCR9
+ −
) were measured, after the first and second doses, as potential correlates of protection. After the first and or second dose, 54% of vaccinees and 13% of placebo recipients had plasma RV IgA. Before vaccination, most (95%) of the children (of both study groups) were breast-fed and had stool RV IgA (68.64%). Co-proconversion (4-fold increase) after the first and or second dose was observed in 32.7% of vaccinees and 17.4% of placebo recipients. No significant difference was seen when comparing the frequencies of any subset of memory B cells between vaccinees and placebo recipients. Statistically significant weak correlations were found between plasma RV IgA titers and coproconversion, and several subsets of memory B cells. The vaccine provided 74.8% protection (95% confidence interval, 30.93-92.62) against any RV gastroenteritis and 100% protection (95% confidence interval, 14.53-100) against severe RV gastroenteritis. When vaccinees and placebo recipients were considered together, a correlation was found between protection from disease and plasma RV IgA measured after dose 2 and RV memory (IgD
−
CD27
+
α
4
β
7
+
CCR9
+
) circulating B cells measured after dose 1. However, the correlation coefficients for both tests were low (<0.2), suggesting that other factors are important in explaining protection from disease.</description><identifier>ISSN: 0882-8245</identifier><identifier>EISSN: 1557-8976</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1089/vim.2006.0105</identifier><identifier>PMID: 17603846</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>B-Lymphocyte Subsets - immunology ; B-Lymphocyte Subsets - metabolism ; Colombia ; Double-Blind Method ; Female ; Human rotavirus ; Humans ; Immunoglobulin A - blood ; Immunoglobulin A - immunology ; Immunoglobulin A - metabolism ; Immunologic Memory ; Infant ; Male ; Rotavirus - immunology ; Rotavirus Infections - immunology ; Rotavirus Infections - prevention & control ; Rotavirus Vaccines - immunology ; Vaccines ; Vaccines, Attenuated - immunology ; Vaccines, Attenuated - therapeutic use</subject><ispartof>Viral Immunology, 2007-06, Vol.20 (2), p.3-311</ispartof><rights>Mary Ann Liebert, Inc.</rights><rights>(©) Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-396ec6201a8848be76ec71b64a9db56635de310e8406f6ebd78707a9eecdd05f3</citedby><cites>FETCH-LOGICAL-c387t-396ec6201a8848be76ec71b64a9db56635de310e8406f6ebd78707a9eecdd05f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17603846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rojas, Olga Lucía</creatorcontrib><creatorcontrib>Caicedo, Liliana</creatorcontrib><creatorcontrib>Guzmán, Carolina</creatorcontrib><creatorcontrib>Rodríguez, Luz-Stella</creatorcontrib><creatorcontrib>Castañeda, Javier</creatorcontrib><creatorcontrib>Uribe, Liliana</creatorcontrib><creatorcontrib>Andrade, Yohanna</creatorcontrib><creatorcontrib>Pinzón, Ricardo</creatorcontrib><creatorcontrib>Narváez, Carlos Fernando</creatorcontrib><creatorcontrib>Lozano, Juan Manuel</creatorcontrib><creatorcontrib>De Vos, Beatrice</creatorcontrib><creatorcontrib>Franco, Manuel A.</creatorcontrib><creatorcontrib>Angel, Juana</creatorcontrib><title>Evaluation of Circulating Intestinally Committed Memory B Cells in Children Vaccinated with Attenuated Human Rotavirus Vaccine</title><title>Viral Immunology</title><addtitle>Viral Immunol</addtitle><description>In a double blind trial, 319 fully immunized children
received two doses of either placebo or 10
6.7
focus-forming units of the attenuated RIX4414 human rotavirus (RV) vaccine ("all-in-one" formulation). Plasma RV-specific IgA (RV IgA), stool RV IgA, and circulating total and RV memory B cells (CD19
+
IgD
+ −
CD27
+
) with an intestinal homing phenotype (α
4
β
7
+
CCR9
+ −
) were measured, after the first and second doses, as potential correlates of protection. After the first and or second dose, 54% of vaccinees and 13% of placebo recipients had plasma RV IgA. Before vaccination, most (95%) of the children (of both study groups) were breast-fed and had stool RV IgA (68.64%). Co-proconversion (4-fold increase) after the first and or second dose was observed in 32.7% of vaccinees and 17.4% of placebo recipients. No significant difference was seen when comparing the frequencies of any subset of memory B cells between vaccinees and placebo recipients. Statistically significant weak correlations were found between plasma RV IgA titers and coproconversion, and several subsets of memory B cells. The vaccine provided 74.8% protection (95% confidence interval, 30.93-92.62) against any RV gastroenteritis and 100% protection (95% confidence interval, 14.53-100) against severe RV gastroenteritis. When vaccinees and placebo recipients were considered together, a correlation was found between protection from disease and plasma RV IgA measured after dose 2 and RV memory (IgD
−
CD27
+
α
4
β
7
+
CCR9
+
) circulating B cells measured after dose 1. However, the correlation coefficients for both tests were low (<0.2), suggesting that other factors are important in explaining protection from disease.</description><subject>B-Lymphocyte Subsets - immunology</subject><subject>B-Lymphocyte Subsets - metabolism</subject><subject>Colombia</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Human rotavirus</subject><subject>Humans</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin A - immunology</subject><subject>Immunoglobulin A - metabolism</subject><subject>Immunologic Memory</subject><subject>Infant</subject><subject>Male</subject><subject>Rotavirus - immunology</subject><subject>Rotavirus Infections - immunology</subject><subject>Rotavirus Infections - prevention & control</subject><subject>Rotavirus Vaccines - immunology</subject><subject>Vaccines</subject><subject>Vaccines, Attenuated - immunology</subject><subject>Vaccines, Attenuated - therapeutic use</subject><issn>0882-8245</issn><issn>1557-8976</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkb1v1TAUxS0Eoq-FkRVZDGx5XOfDdsYSlbZSERICVstJbqgrxy52_NBb-NtxaEQlFhbbx_rdI517CHnFYM9Atu8OZt6XAHwPDJonZMeaRhSyFfwp2YGUZSHLujkhpzHeAYDksnpOTpjgUMma78ivi4O2SS_GO-on2pkwJJul-06v3YIxv7S1R9r5eTbLgiP9iLMPR_qedmhtpMbR7tbYMaCj3_QwZH6lfprllp7nAZf-6Ks0a0c_-0UfTEhxQ_EFeTZpG_Hldp-Rrx8uvnRXxc2ny-vu_KYYKimWomo5DrwEpqWsZY8iS8F6Xut27BvOq2bEigHKGvjEsR-FFCB0iziMIzRTdUbePvjeB_8j5VhqNnHIAbRDn6ISwEXZAvwXZO3K1TyDb_4B73wKeVlRlaytednyMkPFAzQEH2PASd0HM-twVAzUWp_K9am1PrXWl_nXm2nqZxwf6a2vR8P1WztnDfYYlr_gZifyoaoc5zeRSKbs</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Rojas, Olga Lucía</creator><creator>Caicedo, Liliana</creator><creator>Guzmán, Carolina</creator><creator>Rodríguez, Luz-Stella</creator><creator>Castañeda, Javier</creator><creator>Uribe, Liliana</creator><creator>Andrade, Yohanna</creator><creator>Pinzón, Ricardo</creator><creator>Narváez, Carlos Fernando</creator><creator>Lozano, Juan Manuel</creator><creator>De Vos, Beatrice</creator><creator>Franco, Manuel A.</creator><creator>Angel, Juana</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>Evaluation of Circulating Intestinally Committed Memory B Cells in Children Vaccinated with Attenuated Human Rotavirus Vaccine</title><author>Rojas, Olga Lucía ; Caicedo, Liliana ; Guzmán, Carolina ; Rodríguez, Luz-Stella ; Castañeda, Javier ; Uribe, Liliana ; Andrade, Yohanna ; Pinzón, Ricardo ; Narváez, Carlos Fernando ; Lozano, Juan Manuel ; De Vos, Beatrice ; Franco, Manuel A. ; Angel, Juana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-396ec6201a8848be76ec71b64a9db56635de310e8406f6ebd78707a9eecdd05f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>B-Lymphocyte Subsets - immunology</topic><topic>B-Lymphocyte Subsets - metabolism</topic><topic>Colombia</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Human rotavirus</topic><topic>Humans</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin A - immunology</topic><topic>Immunoglobulin A - metabolism</topic><topic>Immunologic Memory</topic><topic>Infant</topic><topic>Male</topic><topic>Rotavirus - immunology</topic><topic>Rotavirus Infections - immunology</topic><topic>Rotavirus Infections - prevention & control</topic><topic>Rotavirus Vaccines - immunology</topic><topic>Vaccines</topic><topic>Vaccines, Attenuated - immunology</topic><topic>Vaccines, Attenuated - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rojas, Olga Lucía</creatorcontrib><creatorcontrib>Caicedo, Liliana</creatorcontrib><creatorcontrib>Guzmán, Carolina</creatorcontrib><creatorcontrib>Rodríguez, Luz-Stella</creatorcontrib><creatorcontrib>Castañeda, Javier</creatorcontrib><creatorcontrib>Uribe, Liliana</creatorcontrib><creatorcontrib>Andrade, Yohanna</creatorcontrib><creatorcontrib>Pinzón, Ricardo</creatorcontrib><creatorcontrib>Narváez, Carlos Fernando</creatorcontrib><creatorcontrib>Lozano, Juan Manuel</creatorcontrib><creatorcontrib>De Vos, Beatrice</creatorcontrib><creatorcontrib>Franco, Manuel A.</creatorcontrib><creatorcontrib>Angel, Juana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Viral Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rojas, Olga Lucía</au><au>Caicedo, Liliana</au><au>Guzmán, Carolina</au><au>Rodríguez, Luz-Stella</au><au>Castañeda, Javier</au><au>Uribe, Liliana</au><au>Andrade, Yohanna</au><au>Pinzón, Ricardo</au><au>Narváez, Carlos Fernando</au><au>Lozano, Juan Manuel</au><au>De Vos, Beatrice</au><au>Franco, Manuel A.</au><au>Angel, Juana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Circulating Intestinally Committed Memory B Cells in Children Vaccinated with Attenuated Human Rotavirus Vaccine</atitle><jtitle>Viral Immunology</jtitle><addtitle>Viral Immunol</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>20</volume><issue>2</issue><spage>3</spage><epage>311</epage><pages>3-311</pages><issn>0882-8245</issn><eissn>1557-8976</eissn><eissn>1365-2567</eissn><abstract>In a double blind trial, 319 fully immunized children
received two doses of either placebo or 10
6.7
focus-forming units of the attenuated RIX4414 human rotavirus (RV) vaccine ("all-in-one" formulation). Plasma RV-specific IgA (RV IgA), stool RV IgA, and circulating total and RV memory B cells (CD19
+
IgD
+ −
CD27
+
) with an intestinal homing phenotype (α
4
β
7
+
CCR9
+ −
) were measured, after the first and second doses, as potential correlates of protection. After the first and or second dose, 54% of vaccinees and 13% of placebo recipients had plasma RV IgA. Before vaccination, most (95%) of the children (of both study groups) were breast-fed and had stool RV IgA (68.64%). Co-proconversion (4-fold increase) after the first and or second dose was observed in 32.7% of vaccinees and 17.4% of placebo recipients. No significant difference was seen when comparing the frequencies of any subset of memory B cells between vaccinees and placebo recipients. Statistically significant weak correlations were found between plasma RV IgA titers and coproconversion, and several subsets of memory B cells. The vaccine provided 74.8% protection (95% confidence interval, 30.93-92.62) against any RV gastroenteritis and 100% protection (95% confidence interval, 14.53-100) against severe RV gastroenteritis. When vaccinees and placebo recipients were considered together, a correlation was found between protection from disease and plasma RV IgA measured after dose 2 and RV memory (IgD
−
CD27
+
α
4
β
7
+
CCR9
+
) circulating B cells measured after dose 1. However, the correlation coefficients for both tests were low (<0.2), suggesting that other factors are important in explaining protection from disease.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>17603846</pmid><doi>10.1089/vim.2006.0105</doi><tpages>309</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Viral Immunology, 2007-06, Vol.20 (2), p.3-311 |
| issn | 0882-8245 1557-8976 1365-2567 |
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| source | MEDLINE; Wiley Online Library Free Content; Access via Wiley Online Library; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism Colombia Double-Blind Method Female Human rotavirus Humans Immunoglobulin A - blood Immunoglobulin A - immunology Immunoglobulin A - metabolism Immunologic Memory Infant Male Rotavirus - immunology Rotavirus Infections - immunology Rotavirus Infections - prevention & control Rotavirus Vaccines - immunology Vaccines Vaccines, Attenuated - immunology Vaccines, Attenuated - therapeutic use |
| title | Evaluation of Circulating Intestinally Committed Memory B Cells in Children Vaccinated with Attenuated Human Rotavirus Vaccine |
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