Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

Function-blocking antibodies to VEGF receptors R1 and R2 were used to probe their roles in controlling angiogenesis in a mouse model of pancreatic islet carcinogenesis. Inhibition of VEGFR2 but not VEGFR1 markedly disrupted angiogenic switching, persistent angiogenesis, and initial tumor growth. In...

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Veröffentlicht in:	Cancer cell 2005-10, Vol.8 (4), p.299-309
Hauptverfasser:	Casanovas, Oriol, Hicklin, Daniel J., Bergers, Gabriele, Hanahan, Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Drug Resistance, Neoplasm Fibroblast Growth Factors - antagonists & inhibitors Fibroblast Growth Factors - metabolism Humans Islets of Langerhans - pathology Neovascularization, Pathologic - prevention & control Pancreatic Neoplasms - blood supply Pancreatic Neoplasms - metabolism Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors Signal Transduction - physiology Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - physiology
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