Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-α dependent up-regulation of matrix metalloproteases

Apart from the neoplastic cells, malignant tumours consist of the extracellular matrix (ECM) and normal cells, in particular tumour-associated macrophages (TAM). To understand the mechanisms by which TAM can influence tumour cell invasion we co-cultured the human breast cancer cell lines MCF-7, SK-B...

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Veröffentlicht in:	Carcinogenesis (New York) 2004-08, Vol.25 (8), p.1543-1549
Hauptverfasser:	Hagemann, Thorsten, Robinson, Stephen C., Schulz, Matthias, Trümper, Lorenz, Balkwill, Frances R., Binder, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Breast Neoplasms - pathology Carcinogenesis, carcinogens and anticarcinogens Cell Line Cell Line, Tumor Coculture Techniques Collagen - pharmacology Densitometry Down-Regulation Drug Combinations ECM Enzyme-Linked Immunosorbent Assay extracellular matrix Humans Laminin - pharmacology Lipopolysaccharides - metabolism Macrophages - metabolism matrix metalloprotease Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 3 - biosynthesis Matrix Metalloproteinase 7 - biosynthesis Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinases - biosynthesis Medical sciences MMP Neoplasm Invasiveness Proteoglycans - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism RNA, Messenger - metabolism TAM TNF-α Tumor Necrosis Factor-alpha - biosynthesis Tumors tumour necrosis factor-alpha tumour-associated macrophages Up-Regulation
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