Treatment of Relapsed Chronic Lymphocytic Leukemia by 72-Hour Continuous Infusion or 1-Hour Bolus Infusion of Flavopiridol: Results from Cancer and Leukemia Group B Study 19805

Purpose: Flavopiridol has in vitro activity in chronic lymphocytic leukemia (CLL) and promotes apoptosis independent of p53 function or prior fludarabine exposure. We sought to determine if flavopiridol has activity in previously treated CLL using two schedules of administration. Patients and Method...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2005-06, Vol.11 (11), p.4176-4181
Hauptverfasser:	Byrd, John C, Peterson, Bercedis L, Gabrilove, Janice, Odenike, Olatoyosi M, Grever, Michael R, Rai, Kanti, Larson, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use CDKs and CDK inhibitors Drug Administration Schedule Female Flavonoids - administration & dosage Flavonoids - adverse effects Flavonoids - therapeutic use Hematologic, other Humans Infusion Pumps Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemias and lymphonas Male Middle Aged Neoplasm Recurrence, Local Neoplasm Staging Neutropenia - chemically induced Piperidines - administration & dosage Piperidines - adverse effects Piperidines - therapeutic use Survival Analysis Thrombocytopenia - chemically induced Treatment Outcome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!