High Molecular Weight Kininogen Regulates Platelet-Leukocyte Interactions by Bridging Mac-1 and Glycoprotein Ib

Leukocyte-platelet interaction is important in mediating leukocyte adhesion to a thrombus and leukocyte recruitment to a site of vascular injury. This interaction is mediated at least in part by the β2-integrin Mac-1 (CD11b/CD18) and its counter-receptor on platelets, glycoprotein Ibα (GPIbα). High...

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Veröffentlicht in:	The Journal of biological chemistry 2003-11, Vol.278 (46), p.45375-45381
Hauptverfasser:	Chavakis, Triantafyllos, Santoso, Sentot, Clemetson, Kenneth J., Sachs, Ulrich J.H., Isordia-Salas, Irma, Pixley, Robin A., Nawroth, Peter P., Colman, Robert W., Preissner, Klaus T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - metabolism Binding Sites Blood Platelets - metabolism Cell Adhesion Cell Communication CHO Cells Cricetinae Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Epitopes Flow Cytometry Humans K562 Cells Kininogen, High-Molecular-Weight - metabolism Kininogen, High-Molecular-Weight - physiology Leukocytes - metabolism Macrophage-1 Antigen - metabolism Neutrophils - metabolism Platelet Glycoprotein GPIb-IX Complex - chemistry Platelet Glycoprotein GPIb-IX Complex - metabolism Protein Binding Protein Structure, Tertiary Transfection U937 Cells
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