Acute necrotising encephalopathy of childhood: A review of two cases

Acute necrotising encephalopathy of childhood (ANEC) is an uncommon disease with characteristic clinical and imaging findings. We present two cases of ANEC secondary to Respiratory Syncytial Virus (RSV) and mycoplasma infections. An eight-month-old boy presented with features of gastroenteritis but...

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Veröffentlicht in:Medical journal of Malaysia 2017-10, Vol.72 (5), p.311-313
Hauptverfasser: Ong, S C L, Nur Azidawati, A H, Liew, Y H, Anita, S
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Nur Azidawati, A H
Liew, Y H
Anita, S
description Acute necrotising encephalopathy of childhood (ANEC) is an uncommon disease with characteristic clinical and imaging findings. We present two cases of ANEC secondary to Respiratory Syncytial Virus (RSV) and mycoplasma infections. An eight-month-old boy presented with features of gastroenteritis but soon developed multiple episodes of seizures. Blood and CSF cultures were negative but nasopharyngeal aspirate immunofluorescence was positive for RSV. A nine-year-old girl presented with abnormal behaviour following two days of prodromal symptoms. Her serological markers implicated mycoplasma (IgM titre 1: 640). CT brain of both patients showed bilateral symmetrical thalamic hypodensities, while MRI revealed more extensive white matter involvements.
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subjects Acute Disease
Child
Encephalitis - diagnosis
Encephalitis - drug therapy
Encephalitis - etiology
Female
Gait Disorders, Neurologic
Humans
Infant
Magnetic Resonance Imaging
Malaysia
Male
Mycoplasma Infections - drug therapy
Mycoplasma Infections - physiopathology
Neuroimaging
Respiratory Syncytial Virus Infections - complications
Respiratory Syncytial Virus Infections - drug therapy
Respiratory Syncytial Virus Infections - physiopathology
title Acute necrotising encephalopathy of childhood: A review of two cases
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