Acute necrotising encephalopathy of childhood: A review of two cases
Acute necrotising encephalopathy of childhood (ANEC) is an uncommon disease with characteristic clinical and imaging findings. We present two cases of ANEC secondary to Respiratory Syncytial Virus (RSV) and mycoplasma infections. An eight-month-old boy presented with features of gastroenteritis but...
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Veröffentlicht in: | Medical journal of Malaysia 2017-10, Vol.72 (5), p.311-313 |
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description | Acute necrotising encephalopathy of childhood (ANEC) is an uncommon disease with characteristic clinical and imaging findings. We present two cases of ANEC secondary to Respiratory Syncytial Virus (RSV) and mycoplasma infections. An eight-month-old boy presented with features of gastroenteritis but soon developed multiple episodes of seizures. Blood and CSF cultures were negative but nasopharyngeal aspirate immunofluorescence was positive for RSV. A nine-year-old girl presented with abnormal behaviour following two days of prodromal symptoms. Her serological markers implicated mycoplasma (IgM titre 1: 640). CT brain of both patients showed bilateral symmetrical thalamic hypodensities, while MRI revealed more extensive white matter involvements. |
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We present two cases of ANEC secondary to Respiratory Syncytial Virus (RSV) and mycoplasma infections. An eight-month-old boy presented with features of gastroenteritis but soon developed multiple episodes of seizures. Blood and CSF cultures were negative but nasopharyngeal aspirate immunofluorescence was positive for RSV. A nine-year-old girl presented with abnormal behaviour following two days of prodromal symptoms. Her serological markers implicated mycoplasma (IgM titre 1: 640). CT brain of both patients showed bilateral symmetrical thalamic hypodensities, while MRI revealed more extensive white matter involvements.</description><subject>Acute Disease</subject><subject>Child</subject><subject>Encephalitis - diagnosis</subject><subject>Encephalitis - drug therapy</subject><subject>Encephalitis - etiology</subject><subject>Female</subject><subject>Gait Disorders, Neurologic</subject><subject>Humans</subject><subject>Infant</subject><subject>Magnetic Resonance Imaging</subject><subject>Malaysia</subject><subject>Male</subject><subject>Mycoplasma Infections - drug therapy</subject><subject>Mycoplasma Infections - physiopathology</subject><subject>Neuroimaging</subject><subject>Respiratory Syncytial Virus Infections - complications</subject><subject>Respiratory Syncytial Virus Infections - drug therapy</subject><subject>Respiratory Syncytial Virus Infections - physiopathology</subject><issn>0300-5283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j01LxDAURbNQnGGcvyBZuimkySRp3ZXxEwbc6LokL6820ja1SR3m31txvJsLl8uBc0HWTDCWSV6IFdnG-MmWKLmM6oqseJmXuijKNbmvYE5IB4QpJB_98EFxABxb04XRpPZEQ0Oh9Z1rQ3B3tKITfns8_s7pGCiYiPGaXDami7g994a8Pz687Z-zw-vTy746ZGPOVcp2oLXlWEptEZhADqpRTqIWJYoid04qt3OSaS0EMCstWu14joUCKwUHsSG3f9xxCl8zxlT3PgJ2nRkwzLFepPgimC-ADbk5X2fbo6vHyfdmOtX_5uIHgHpUWQ</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Ong, S C L</creator><creator>Nur Azidawati, A H</creator><creator>Liew, Y H</creator><creator>Anita, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201710</creationdate><title>Acute necrotising encephalopathy of childhood: A review of two cases</title><author>Ong, S C L ; Nur Azidawati, A H ; Liew, Y H ; Anita, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-4c77b2e957bec03e2c6f6d5e739e381dd56d4d507733c0b5beb7d21e86cb532c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acute Disease</topic><topic>Child</topic><topic>Encephalitis - diagnosis</topic><topic>Encephalitis - drug therapy</topic><topic>Encephalitis - etiology</topic><topic>Female</topic><topic>Gait Disorders, Neurologic</topic><topic>Humans</topic><topic>Infant</topic><topic>Magnetic Resonance Imaging</topic><topic>Malaysia</topic><topic>Male</topic><topic>Mycoplasma Infections - drug therapy</topic><topic>Mycoplasma Infections - physiopathology</topic><topic>Neuroimaging</topic><topic>Respiratory Syncytial Virus Infections - complications</topic><topic>Respiratory Syncytial Virus Infections - drug therapy</topic><topic>Respiratory Syncytial Virus Infections - physiopathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Ong, S C L</creatorcontrib><creatorcontrib>Nur Azidawati, A H</creatorcontrib><creatorcontrib>Liew, Y H</creatorcontrib><creatorcontrib>Anita, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Medical journal of Malaysia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ong, S C L</au><au>Nur Azidawati, A H</au><au>Liew, Y H</au><au>Anita, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute necrotising encephalopathy of childhood: A review of two cases</atitle><jtitle>Medical journal of Malaysia</jtitle><addtitle>Med J Malaysia</addtitle><date>2017-10</date><risdate>2017</risdate><volume>72</volume><issue>5</issue><spage>311</spage><epage>313</epage><pages>311-313</pages><issn>0300-5283</issn><abstract>Acute necrotising encephalopathy of childhood (ANEC) is an uncommon disease with characteristic clinical and imaging findings. We present two cases of ANEC secondary to Respiratory Syncytial Virus (RSV) and mycoplasma infections. An eight-month-old boy presented with features of gastroenteritis but soon developed multiple episodes of seizures. Blood and CSF cultures were negative but nasopharyngeal aspirate immunofluorescence was positive for RSV. A nine-year-old girl presented with abnormal behaviour following two days of prodromal symptoms. Her serological markers implicated mycoplasma (IgM titre 1: 640). CT brain of both patients showed bilateral symmetrical thalamic hypodensities, while MRI revealed more extensive white matter involvements.</abstract><cop>Malaysia</cop><pmid>29197889</pmid><tpages>3</tpages></addata></record> |
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subjects | Acute Disease Child Encephalitis - diagnosis Encephalitis - drug therapy Encephalitis - etiology Female Gait Disorders, Neurologic Humans Infant Magnetic Resonance Imaging Malaysia Male Mycoplasma Infections - drug therapy Mycoplasma Infections - physiopathology Neuroimaging Respiratory Syncytial Virus Infections - complications Respiratory Syncytial Virus Infections - drug therapy Respiratory Syncytial Virus Infections - physiopathology |
title | Acute necrotising encephalopathy of childhood: A review of two cases |
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