Needle use and dosimetric evaluation in cervical cancer brachytherapy using the Utrecht applicator
To analyse the clinical use of needles and examine the feasibility to meet the planning criteria in three fractions of cervical cancer brachytherapy. Furthermore, to investigate whether the needles with the largest discrepancy between application and loading are essential to treatment planning. For...
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| Veröffentlicht in: | Radiotherapy and oncology 2018-03, Vol.126 (3), p.411-416 |
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| container_title | Radiotherapy and oncology |
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| creator | Smolic, Milena Sombroek, Chèrita Bloemers, Monique C.W.M. van Triest, Baukelien Nowee, Marlies E. Mans, Anton |
| description | To analyse the clinical use of needles and examine the feasibility to meet the planning criteria in three fractions of cervical cancer brachytherapy. Furthermore, to investigate whether the needles with the largest discrepancy between application and loading are essential to treatment planning.
For 22 patients we analysed the applied and loaded needle patterns, and examined the dosimetric results for small ( |
| doi_str_mv | 10.1016/j.radonc.2017.11.007 |
| format | Article |
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For 22 patients we analysed the applied and loaded needle patterns, and examined the dosimetric results for small (<30 cm3) and large (≥30 cm3) CTVHR. We removed from the clinical plans (CP) the needles applied most, but with the lowest loading frequency and intensity and re-optimized these plans (RP).
On average 5.8 needles were applied and 4.8 loaded per fraction, with average intensity 22% (17% for small, 29% for large CTVHR). Mid-lateral needles were applied and loaded most frequently and intensely. The average CTVHR D90% prescribed dose was 88.8 Gy (SD 4.2) EQD210, the average OAR D2cm3 limit was respected. Omitting the mid-ventral needles, minimal statistically significant differences were found in dose distributions between RP and CP.
Applying on average 5.8 needles per fraction it was possible to meet the planning criteria for targets and OARs in three BT fractions for both small and large CTVHR. The mid-ventral needles were not essential in treatment planning, unless situated in the vicinity of the GTVres.</description><identifier>ISSN: 0167-8140</identifier><identifier>EISSN: 1879-0887</identifier><identifier>DOI: 10.1016/j.radonc.2017.11.007</identifier><identifier>PMID: 29198407</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Brachytherapy ; Cervical cancer ; Needle use ; Utrecht applicator</subject><ispartof>Radiotherapy and oncology, 2018-03, Vol.126 (3), p.411-416</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-eb0fedddf2b784217cc09c71fcf338e6476e3efba94457c90bf5b6e50fc2cc473</citedby><cites>FETCH-LOGICAL-c428t-eb0fedddf2b784217cc09c71fcf338e6476e3efba94457c90bf5b6e50fc2cc473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167814017327238$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29198407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smolic, Milena</creatorcontrib><creatorcontrib>Sombroek, Chèrita</creatorcontrib><creatorcontrib>Bloemers, Monique C.W.M.</creatorcontrib><creatorcontrib>van Triest, Baukelien</creatorcontrib><creatorcontrib>Nowee, Marlies E.</creatorcontrib><creatorcontrib>Mans, Anton</creatorcontrib><title>Needle use and dosimetric evaluation in cervical cancer brachytherapy using the Utrecht applicator</title><title>Radiotherapy and oncology</title><addtitle>Radiother Oncol</addtitle><description>To analyse the clinical use of needles and examine the feasibility to meet the planning criteria in three fractions of cervical cancer brachytherapy. Furthermore, to investigate whether the needles with the largest discrepancy between application and loading are essential to treatment planning.
For 22 patients we analysed the applied and loaded needle patterns, and examined the dosimetric results for small (<30 cm3) and large (≥30 cm3) CTVHR. We removed from the clinical plans (CP) the needles applied most, but with the lowest loading frequency and intensity and re-optimized these plans (RP).
On average 5.8 needles were applied and 4.8 loaded per fraction, with average intensity 22% (17% for small, 29% for large CTVHR). Mid-lateral needles were applied and loaded most frequently and intensely. The average CTVHR D90% prescribed dose was 88.8 Gy (SD 4.2) EQD210, the average OAR D2cm3 limit was respected. Omitting the mid-ventral needles, minimal statistically significant differences were found in dose distributions between RP and CP.
Applying on average 5.8 needles per fraction it was possible to meet the planning criteria for targets and OARs in three BT fractions for both small and large CTVHR. The mid-ventral needles were not essential in treatment planning, unless situated in the vicinity of the GTVres.</description><subject>Brachytherapy</subject><subject>Cervical cancer</subject><subject>Needle use</subject><subject>Utrecht applicator</subject><issn>0167-8140</issn><issn>1879-0887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kMFq3DAQhkVJaTZp36AEHXOxO7K1K_kSCCFtA6G9NGchj0ZdLV7bkeSFffsqbNJjTjMD3z_DfIx9FVALEJtvuzpaN41YNyBULUQNoD6wldCqq0BrdcZWBVOVFhLO2UVKOwBooFWf2HnTiU5LUCvW_yJyA_ElEbej425KYU85BuR0sMNic5hGHkaOFA8B7cDRjqXnfbS4PeYtRTsfSzyMf3mZ-FOOhNvM7TwPhc9T_Mw-ejsk-vJaL9nT9_s_dz-rx98_Hu5uHyuUjc4V9eDJOeebXmnZCIUIHSrh0betpo1UG2rJ97aTcq2wg96v-w2twWODKFV7ya5Pe-c4PS-UstmHhDQMdqRpSUZ0qmlBgIaCyhOKcUopkjdzDHsbj0aAebFrduZk17zYNUKYYrfErl4vLP2e3P_Qm84C3JwAKn8eAkWTMFDx5UKxko2bwvsX_gFVOo-V</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Smolic, Milena</creator><creator>Sombroek, Chèrita</creator><creator>Bloemers, Monique C.W.M.</creator><creator>van Triest, Baukelien</creator><creator>Nowee, Marlies E.</creator><creator>Mans, Anton</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201803</creationdate><title>Needle use and dosimetric evaluation in cervical cancer brachytherapy using the Utrecht applicator</title><author>Smolic, Milena ; Sombroek, Chèrita ; Bloemers, Monique C.W.M. ; van Triest, Baukelien ; Nowee, Marlies E. ; Mans, Anton</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-eb0fedddf2b784217cc09c71fcf338e6476e3efba94457c90bf5b6e50fc2cc473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Brachytherapy</topic><topic>Cervical cancer</topic><topic>Needle use</topic><topic>Utrecht applicator</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smolic, Milena</creatorcontrib><creatorcontrib>Sombroek, Chèrita</creatorcontrib><creatorcontrib>Bloemers, Monique C.W.M.</creatorcontrib><creatorcontrib>van Triest, Baukelien</creatorcontrib><creatorcontrib>Nowee, Marlies E.</creatorcontrib><creatorcontrib>Mans, Anton</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiotherapy and oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smolic, Milena</au><au>Sombroek, Chèrita</au><au>Bloemers, Monique C.W.M.</au><au>van Triest, Baukelien</au><au>Nowee, Marlies E.</au><au>Mans, Anton</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Needle use and dosimetric evaluation in cervical cancer brachytherapy using the Utrecht applicator</atitle><jtitle>Radiotherapy and oncology</jtitle><addtitle>Radiother Oncol</addtitle><date>2018-03</date><risdate>2018</risdate><volume>126</volume><issue>3</issue><spage>411</spage><epage>416</epage><pages>411-416</pages><issn>0167-8140</issn><eissn>1879-0887</eissn><abstract>To analyse the clinical use of needles and examine the feasibility to meet the planning criteria in three fractions of cervical cancer brachytherapy. Furthermore, to investigate whether the needles with the largest discrepancy between application and loading are essential to treatment planning.
For 22 patients we analysed the applied and loaded needle patterns, and examined the dosimetric results for small (<30 cm3) and large (≥30 cm3) CTVHR. We removed from the clinical plans (CP) the needles applied most, but with the lowest loading frequency and intensity and re-optimized these plans (RP).
On average 5.8 needles were applied and 4.8 loaded per fraction, with average intensity 22% (17% for small, 29% for large CTVHR). Mid-lateral needles were applied and loaded most frequently and intensely. The average CTVHR D90% prescribed dose was 88.8 Gy (SD 4.2) EQD210, the average OAR D2cm3 limit was respected. Omitting the mid-ventral needles, minimal statistically significant differences were found in dose distributions between RP and CP.
Applying on average 5.8 needles per fraction it was possible to meet the planning criteria for targets and OARs in three BT fractions for both small and large CTVHR. The mid-ventral needles were not essential in treatment planning, unless situated in the vicinity of the GTVres.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>29198407</pmid><doi>10.1016/j.radonc.2017.11.007</doi><tpages>6</tpages></addata></record> |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Brachytherapy Cervical cancer Needle use Utrecht applicator |
| title | Needle use and dosimetric evaluation in cervical cancer brachytherapy using the Utrecht applicator |
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