Association Study between Casein Kinase 1 Epsilon Gene and Methamphetamine Dependence

Casein kinase 1 epsilon (CKIɛ) is a component of the DARPP‐32 in second‐messenger pathway. CKIɛ phosphorylates and activates DARPP‐32, a key molecule in various complex signaling pathways, including dopamine and glutamine signaling, which have both been demonstrated to be main pathways in substance...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2008-10, Vol.1139 (1), p.43-48
Hauptverfasser:	Kotaka, T., Ujike, H., Morita, Y., Kishimoto, M., Okahisa, Y., Inada, T., Harano, M., Komiyama, T., Hori, T., Yamada, M., Sekine, Y., Iwata, N., Iyo, M., Sora, I., Ozaki, N., Kuroda, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amphetamine-Related Disorders - genetics Animals Asian Continental Ancestry Group - genetics case-control association study casein kinase I epsilon gene Casein Kinase Iepsilon - genetics Casein Kinase Iepsilon - metabolism clinical phenotype DARPP-32 Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism Dopamine Uptake Inhibitors - pharmacology Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Male Methamphetamine - pharmacology methamphetamine dependence methamphetamine psychosis Mice Middle Aged Phenotype Polymorphism, Genetic Psychoses, Substance-Induced Second Messenger Systems - physiology
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