TGF-β synergizes with ML264 to block IL-1β-induced matrix degradation mediated by Krüppel-like factor 5 in the nucleus pulposus

Intervertebral disc degeneration causes low back pain.Interleukin-1β (IL-1β) is a well-known inflammatory mediator that is involved in disc degeneration but its molecular mechanisms on catabolic and anabolic events in nucleus pulposus (NP) cells remain unclear. Krüppel-like factor 5 (KLF5) is associ...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2018-02, Vol.1864 (2), p.579-589
Hauptverfasser:	Xie, Ziang, Jie, Zhiwei, Wang, Gangliang, Sun, Xuewu, Tang, Pan, Chen, Shuai, Qin, An, Wang, Jian, Fan, Shunwu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - pharmacology Animals Cartilage - pathology Cells, Cultured Cyclic S-Oxides - pharmacology Drug Synergism Humans IL-1β Inflammation Interleukin-1beta - pharmacology Intervertebral disc degeneration Intervertebral Disc Degeneration - metabolism Kruppel-Like Transcription Factors - metabolism Krüppel-like factor 5 Male Nucleus pulposus Nucleus Pulposus - cytology Nucleus Pulposus - metabolism Phosphorylation Proteasome Endopeptidase Complex - metabolism Rats Rats, Sprague-Dawley TGF-β Transforming Growth Factor beta1 - pharmacology Ubiquitin-Protein Ligases - metabolism
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