Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation
Surfactant protein D (SP-D) is produced primarily in the lung and is involved in regulating pulmonary surfactants, lipid homeostasis and innate immunity. Circulating SP-D levels in blood are associated with chronic obstructive pulmonary disease (COPD), although causality remains elusive.In 4061 subj...
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| Veröffentlicht in: | The European respiratory journal 2017-11, Vol.50 (5), p.1700657-1700657 |
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| creator | Obeidat, Ma'en Li, Xuan Burgess, Stephen Zhou, Guohai Fishbane, Nick Hansel, Nadia N Bossé, Yohan Joubert, Philippe Hao, Ke Nickle, David C van den Berge, Maarten Timens, Wim Cho, Michael H Hobbs, Brian D de Jong, Kim Boezen, Marike Hung, Rayjean J Rafaels, Nicholas Mathias, Rasika Ruczinski, Ingo Beaty, Terri H Barnes, Kathleen C Paré, Peter D Sin, Don D |
| description | Surfactant protein D (SP-D) is produced primarily in the lung and is involved in regulating pulmonary surfactants, lipid homeostasis and innate immunity. Circulating SP-D levels in blood are associated with chronic obstructive pulmonary disease (COPD), although causality remains elusive.In 4061 subjects with COPD, we identified genetic variants associated with serum SP-D levels. We then determined whether these variants affected lung tissue gene expression in 1037 individuals. A Mendelian randomisation framework was then applied, whereby serum SP-D-associated variants were tested for association with COPD risk in 11 157 cases and 36 699 controls and with 11 years decline of lung function in the 4061 individuals.Three regions on chromosomes 6 (human leukocyte antigen region), 10 (
gene) and 16 (
gene) were associated with serum SP-D levels at genome-wide significance. In Mendelian randomisation analyses, variants associated with increased serum SP-D levels decreased the risk of COPD (estimate -0.19, p=6.46×10
) and slowed the lung function decline (estimate=0.0038, p=7.68×10
).Leveraging genetic variation effect on protein, lung gene expression and disease phenotypes provided novel insights into SP-D biology and established a causal link between increased SP-D levels and protection against COPD risk and progression. SP-D represents a very promising biomarker and therapeutic target for COPD. |
| doi_str_mv | 10.1183/13993003.00657-2017 |
| format | Article |
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gene) and 16 (
gene) were associated with serum SP-D levels at genome-wide significance. In Mendelian randomisation analyses, variants associated with increased serum SP-D levels decreased the risk of COPD (estimate -0.19, p=6.46×10
) and slowed the lung function decline (estimate=0.0038, p=7.68×10
).Leveraging genetic variation effect on protein, lung gene expression and disease phenotypes provided novel insights into SP-D biology and established a causal link between increased SP-D levels and protection against COPD risk and progression. SP-D represents a very promising biomarker and therapeutic target for COPD.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/13993003.00657-2017</identifier><identifier>PMID: 29191953</identifier><language>eng</language><publisher>England: European Respiratory Society Journals Ltd</publisher><subject>Adult ; Biomarkers - blood ; Case-Control Studies ; Chronic obstructive pulmonary disease ; Disease Progression ; Female ; Gene expression ; Genetic diversity ; Genomes ; Histocompatibility antigen HLA ; Homeostasis ; Humans ; Innate immunity ; Linear Models ; Lung - physiopathology ; Lung diseases ; Male ; Mendelian Randomization Analysis ; Middle Aged ; Obstructive lung disease ; Phenotype ; Polymorphism, Single Nucleotide ; Protein D ; Proteins ; Pulmonary Disease, Chronic Obstructive - blood ; Pulmonary Disease, Chronic Obstructive - genetics ; Pulmonary Surfactant-Associated Protein D - blood ; Respiratory function ; Risk Factors ; Surfactant protein D ; Surfactants</subject><ispartof>The European respiratory journal, 2017-11, Vol.50 (5), p.1700657-1700657</ispartof><rights>Copyright ©ERS 2017.</rights><rights>Copyright European Respiratory Society Journals Ltd. Nov 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c328t-d7d4c953d4eca023641c5e923cd1aeace110bcb8d1d52bcd33a9d5ed9811c603</cites><orcidid>0000-0002-3067-3711 ; 0000-0001-9564-0745 ; 0000-0002-5443-2752</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29191953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Obeidat, Ma'en</creatorcontrib><creatorcontrib>Li, Xuan</creatorcontrib><creatorcontrib>Burgess, Stephen</creatorcontrib><creatorcontrib>Zhou, Guohai</creatorcontrib><creatorcontrib>Fishbane, Nick</creatorcontrib><creatorcontrib>Hansel, Nadia N</creatorcontrib><creatorcontrib>Bossé, Yohan</creatorcontrib><creatorcontrib>Joubert, Philippe</creatorcontrib><creatorcontrib>Hao, Ke</creatorcontrib><creatorcontrib>Nickle, David C</creatorcontrib><creatorcontrib>van den Berge, Maarten</creatorcontrib><creatorcontrib>Timens, Wim</creatorcontrib><creatorcontrib>Cho, Michael H</creatorcontrib><creatorcontrib>Hobbs, Brian D</creatorcontrib><creatorcontrib>de Jong, Kim</creatorcontrib><creatorcontrib>Boezen, Marike</creatorcontrib><creatorcontrib>Hung, Rayjean J</creatorcontrib><creatorcontrib>Rafaels, Nicholas</creatorcontrib><creatorcontrib>Mathias, Rasika</creatorcontrib><creatorcontrib>Ruczinski, Ingo</creatorcontrib><creatorcontrib>Beaty, Terri H</creatorcontrib><creatorcontrib>Barnes, Kathleen C</creatorcontrib><creatorcontrib>Paré, Peter D</creatorcontrib><creatorcontrib>Sin, Don D</creatorcontrib><creatorcontrib>International COPD Genetics Consortium, Lung eQTL Consortium, Lung Health Study</creatorcontrib><title>Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>Surfactant protein D (SP-D) is produced primarily in the lung and is involved in regulating pulmonary surfactants, lipid homeostasis and innate immunity. Circulating SP-D levels in blood are associated with chronic obstructive pulmonary disease (COPD), although causality remains elusive.In 4061 subjects with COPD, we identified genetic variants associated with serum SP-D levels. We then determined whether these variants affected lung tissue gene expression in 1037 individuals. A Mendelian randomisation framework was then applied, whereby serum SP-D-associated variants were tested for association with COPD risk in 11 157 cases and 36 699 controls and with 11 years decline of lung function in the 4061 individuals.Three regions on chromosomes 6 (human leukocyte antigen region), 10 (
gene) and 16 (
gene) were associated with serum SP-D levels at genome-wide significance. In Mendelian randomisation analyses, variants associated with increased serum SP-D levels decreased the risk of COPD (estimate -0.19, p=6.46×10
) and slowed the lung function decline (estimate=0.0038, p=7.68×10
).Leveraging genetic variation effect on protein, lung gene expression and disease phenotypes provided novel insights into SP-D biology and established a causal link between increased SP-D levels and protection against COPD risk and progression. SP-D represents a very promising biomarker and therapeutic target for COPD.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gene expression</subject><subject>Genetic diversity</subject><subject>Genomes</subject><subject>Histocompatibility antigen HLA</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Innate immunity</subject><subject>Linear Models</subject><subject>Lung - physiopathology</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Mendelian Randomization Analysis</subject><subject>Middle Aged</subject><subject>Obstructive lung disease</subject><subject>Phenotype</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Protein D</subject><subject>Proteins</subject><subject>Pulmonary Disease, Chronic Obstructive - blood</subject><subject>Pulmonary Disease, Chronic Obstructive - genetics</subject><subject>Pulmonary Surfactant-Associated Protein D - blood</subject><subject>Respiratory function</subject><subject>Risk Factors</subject><subject>Surfactant protein D</subject><subject>Surfactants</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLAzEUhYMotlZ_gSABN25Gc3PnFXfS-oJKBbtxNWSSDEydTmoys_Dfm-nDhVwuFw7nHg4fIZfAbgFyvAMUAhnDW8bSJIs4g-yIjAc1GuRjMmaCYQQC0xE5837FGKQxwikZcQFhEhyTz4_eVVJ1su3oxtnO1C2d0dpTSZXsvWyoq_0XHSzW0SrsdPE-u6fO-L7pPLUVfTOtNk0tW-pkq-269rKrbXtOTirZeHOxvxOyfHpcTl-i-eL5dfowjxTyvIt0pmMVqujYKMk4pjGoxAiOSoM0UhkAVqoy16ATXiqNKIVOjBY5gEoZTsjNLja0_-6N74pQQJmmka2xvS9AZJAmeRKITcj1P-vK9q4N5YIrjzHnfBuIO5dy1ntnqmLj6rV0PwWwYgBfHMAXW_DFAD58Xe2z-3Jt9N_PgTT-AjIjfVE</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Obeidat, Ma'en</creator><creator>Li, Xuan</creator><creator>Burgess, Stephen</creator><creator>Zhou, Guohai</creator><creator>Fishbane, Nick</creator><creator>Hansel, Nadia N</creator><creator>Bossé, Yohan</creator><creator>Joubert, Philippe</creator><creator>Hao, Ke</creator><creator>Nickle, David C</creator><creator>van den Berge, Maarten</creator><creator>Timens, Wim</creator><creator>Cho, Michael H</creator><creator>Hobbs, Brian D</creator><creator>de Jong, Kim</creator><creator>Boezen, Marike</creator><creator>Hung, Rayjean J</creator><creator>Rafaels, Nicholas</creator><creator>Mathias, Rasika</creator><creator>Ruczinski, Ingo</creator><creator>Beaty, Terri H</creator><creator>Barnes, Kathleen C</creator><creator>Paré, Peter D</creator><creator>Sin, Don D</creator><general>European Respiratory Society Journals Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3067-3711</orcidid><orcidid>https://orcid.org/0000-0001-9564-0745</orcidid><orcidid>https://orcid.org/0000-0002-5443-2752</orcidid></search><sort><creationdate>201711</creationdate><title>Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation</title><author>Obeidat, Ma'en ; Li, Xuan ; Burgess, Stephen ; Zhou, Guohai ; Fishbane, Nick ; Hansel, Nadia N ; Bossé, Yohan ; Joubert, Philippe ; Hao, Ke ; Nickle, David C ; van den Berge, Maarten ; Timens, Wim ; Cho, Michael H ; Hobbs, Brian D ; de Jong, Kim ; Boezen, Marike ; Hung, Rayjean J ; Rafaels, Nicholas ; Mathias, Rasika ; Ruczinski, Ingo ; Beaty, Terri H ; Barnes, Kathleen C ; Paré, Peter D ; Sin, Don D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-d7d4c953d4eca023641c5e923cd1aeace110bcb8d1d52bcd33a9d5ed9811c603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Gene expression</topic><topic>Genetic diversity</topic><topic>Genomes</topic><topic>Histocompatibility antigen HLA</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Innate immunity</topic><topic>Linear Models</topic><topic>Lung - physiopathology</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Mendelian Randomization Analysis</topic><topic>Middle Aged</topic><topic>Obstructive lung disease</topic><topic>Phenotype</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Protein D</topic><topic>Proteins</topic><topic>Pulmonary Disease, Chronic Obstructive - blood</topic><topic>Pulmonary Disease, Chronic Obstructive - genetics</topic><topic>Pulmonary Surfactant-Associated Protein D - blood</topic><topic>Respiratory function</topic><topic>Risk Factors</topic><topic>Surfactant protein D</topic><topic>Surfactants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obeidat, Ma'en</creatorcontrib><creatorcontrib>Li, Xuan</creatorcontrib><creatorcontrib>Burgess, Stephen</creatorcontrib><creatorcontrib>Zhou, Guohai</creatorcontrib><creatorcontrib>Fishbane, Nick</creatorcontrib><creatorcontrib>Hansel, Nadia N</creatorcontrib><creatorcontrib>Bossé, Yohan</creatorcontrib><creatorcontrib>Joubert, Philippe</creatorcontrib><creatorcontrib>Hao, Ke</creatorcontrib><creatorcontrib>Nickle, David C</creatorcontrib><creatorcontrib>van den Berge, Maarten</creatorcontrib><creatorcontrib>Timens, Wim</creatorcontrib><creatorcontrib>Cho, Michael H</creatorcontrib><creatorcontrib>Hobbs, Brian D</creatorcontrib><creatorcontrib>de Jong, Kim</creatorcontrib><creatorcontrib>Boezen, Marike</creatorcontrib><creatorcontrib>Hung, Rayjean J</creatorcontrib><creatorcontrib>Rafaels, Nicholas</creatorcontrib><creatorcontrib>Mathias, Rasika</creatorcontrib><creatorcontrib>Ruczinski, Ingo</creatorcontrib><creatorcontrib>Beaty, Terri H</creatorcontrib><creatorcontrib>Barnes, Kathleen C</creatorcontrib><creatorcontrib>Paré, Peter D</creatorcontrib><creatorcontrib>Sin, Don D</creatorcontrib><creatorcontrib>International COPD Genetics Consortium, Lung eQTL Consortium, Lung Health Study</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obeidat, Ma'en</au><au>Li, Xuan</au><au>Burgess, Stephen</au><au>Zhou, Guohai</au><au>Fishbane, Nick</au><au>Hansel, Nadia N</au><au>Bossé, Yohan</au><au>Joubert, Philippe</au><au>Hao, Ke</au><au>Nickle, David C</au><au>van den Berge, Maarten</au><au>Timens, Wim</au><au>Cho, Michael H</au><au>Hobbs, Brian D</au><au>de Jong, Kim</au><au>Boezen, Marike</au><au>Hung, Rayjean J</au><au>Rafaels, Nicholas</au><au>Mathias, Rasika</au><au>Ruczinski, Ingo</au><au>Beaty, Terri H</au><au>Barnes, Kathleen C</au><au>Paré, Peter D</au><au>Sin, Don D</au><aucorp>International COPD Genetics Consortium, Lung eQTL Consortium, Lung Health Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2017-11</date><risdate>2017</risdate><volume>50</volume><issue>5</issue><spage>1700657</spage><epage>1700657</epage><pages>1700657-1700657</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>Surfactant protein D (SP-D) is produced primarily in the lung and is involved in regulating pulmonary surfactants, lipid homeostasis and innate immunity. Circulating SP-D levels in blood are associated with chronic obstructive pulmonary disease (COPD), although causality remains elusive.In 4061 subjects with COPD, we identified genetic variants associated with serum SP-D levels. We then determined whether these variants affected lung tissue gene expression in 1037 individuals. A Mendelian randomisation framework was then applied, whereby serum SP-D-associated variants were tested for association with COPD risk in 11 157 cases and 36 699 controls and with 11 years decline of lung function in the 4061 individuals.Three regions on chromosomes 6 (human leukocyte antigen region), 10 (
gene) and 16 (
gene) were associated with serum SP-D levels at genome-wide significance. In Mendelian randomisation analyses, variants associated with increased serum SP-D levels decreased the risk of COPD (estimate -0.19, p=6.46×10
) and slowed the lung function decline (estimate=0.0038, p=7.68×10
).Leveraging genetic variation effect on protein, lung gene expression and disease phenotypes provided novel insights into SP-D biology and established a causal link between increased SP-D levels and protection against COPD risk and progression. SP-D represents a very promising biomarker and therapeutic target for COPD.</abstract><cop>England</cop><pub>European Respiratory Society Journals Ltd</pub><pmid>29191953</pmid><doi>10.1183/13993003.00657-2017</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-3067-3711</orcidid><orcidid>https://orcid.org/0000-0001-9564-0745</orcidid><orcidid>https://orcid.org/0000-0002-5443-2752</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0903-1936 |
| ispartof | The European respiratory journal, 2017-11, Vol.50 (5), p.1700657-1700657 |
| issn | 0903-1936 1399-3003 |
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| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Adult Biomarkers - blood Case-Control Studies Chronic obstructive pulmonary disease Disease Progression Female Gene expression Genetic diversity Genomes Histocompatibility antigen HLA Homeostasis Humans Innate immunity Linear Models Lung - physiopathology Lung diseases Male Mendelian Randomization Analysis Middle Aged Obstructive lung disease Phenotype Polymorphism, Single Nucleotide Protein D Proteins Pulmonary Disease, Chronic Obstructive - blood Pulmonary Disease, Chronic Obstructive - genetics Pulmonary Surfactant-Associated Protein D - blood Respiratory function Risk Factors Surfactant protein D Surfactants |
| title | Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation |
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