Both Autocrine Signaling and Paracrine Signaling of HB-EGF Enhance Ocular Neovascularization

The incidence of blindness is increasing because of the increase in abnormal ocular neovascularization. Anti-VEGF (vascular endothelial growth factor) therapies have led to good results, although they are not a cure for the blindness. The purpose of this study was to determine what role HB-EGF (hepa...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2018-01, Vol.38 (1), p.174-185
Hauptverfasser:	Inoue, Yuki, Shimazawa, Masamitsu, Nakamura, Shinsuke, Takata, Shinsuke, Hashimoto, Yuhei, Izawa, Hiroshi, Masuda, Tomomi, Tsuruma, Kazuhiro, Sakaue, Tomohisa, Nakayama, Hironao, Higashiyama, Shigeki, Hara, Hideaki
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM12 Protein - genetics ADAM12 Protein - metabolism ADAM17 Protein - genetics ADAM17 Protein - metabolism Angiogenesis Inhibitors - pharmacology Animals Autocrine Communication - drug effects Bacterial Proteins - pharmacology Callithrix Cell Movement Cell Proliferation Cells, Cultured Choroidal Neovascularization - genetics Choroidal Neovascularization - metabolism Choroidal Neovascularization - pathology Choroidal Neovascularization - prevention & control Disease Models, Animal Endothelial Cells - metabolism Endothelial Cells - pathology Extracellular Signal-Regulated MAP Kinases - metabolism Heparin-binding EGF-like Growth Factor - deficiency Heparin-binding EGF-like Growth Factor - genetics Heparin-binding EGF-like Growth Factor - metabolism Humans Mice, Knockout Neovascularization, Pathologic Paracrine Communication - drug effects Retinal Neovascularization - genetics Retinal Neovascularization - metabolism Retinal Neovascularization - pathology Retinal Neovascularization - prevention & control Retinal Vessels - drug effects Retinal Vessels - metabolism Retinal Vessels - pathology Signal Transduction Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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