Predictors of Vitamin D deficiency in predialysis patients with stage 3-5 chronic kidney diseases in Southern China
Vitamin D status and risk factors of Vitamin D deficiency in chronic kidney disease (CKD) patients in China have been seldom reported before. In this study, we aim to investigate serum 25-hydroxyvitamin D [25(OH)D] status and find the predictors of Vitamin D deficiency in predialysis patients with S...
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| Veröffentlicht in: | Nigerian journal of clinical practice 2017-10, Vol.20 (10), p.1309-1315 |
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| creator | Feng, M Lv, J Huang, F T Liang, P F Fu, S Zeng, Y C Tang, Y Xu, A P |
| description | Vitamin D status and risk factors of Vitamin D deficiency in chronic kidney disease (CKD) patients in China have been seldom reported before. In this study, we aim to investigate serum 25-hydroxyvitamin D [25(OH)D] status and find the predictors of Vitamin D deficiency in predialysis patients with Stage 3-5 CKDs in Southern China.
In this retrospective cross-sectional study, hospitalized predialysis patients who were diagnosed of Stage 3-5 CKD and had taken measurement of serum 25(OH)D in a single center from January 2014 to June 2015 were included. Patients were divided into Vitamin D deficiency group and nondeficiency group depending on the cutoff serum 25(OH)D value of 37 nmol/L. Clinical and biochemical parameters were collected and evaluated for predictors of Vitamin D deficiency by logistic regression.
One hundred and fifty-two patients were included in this study, of which 87 (57.2%) were in Vitamin D insufficiency state while 60 (39.5%) were in Vitamin D deficiency state. Serum 25(OH)D levels of patients in Stage 4 and Stage 5 CKD were lower than that of patients in Stage 3 CKD (P = 0.002). It was discovered that female gender (odds ratio [OR] = 3.674; 95% confidence interval [CI], 1.607-8.396; P = 0.002), serum albumin level |
| doi_str_mv | 10.4103/njcp.njcp_27_17 |
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In this retrospective cross-sectional study, hospitalized predialysis patients who were diagnosed of Stage 3-5 CKD and had taken measurement of serum 25(OH)D in a single center from January 2014 to June 2015 were included. Patients were divided into Vitamin D deficiency group and nondeficiency group depending on the cutoff serum 25(OH)D value of 37 nmol/L. Clinical and biochemical parameters were collected and evaluated for predictors of Vitamin D deficiency by logistic regression.
One hundred and fifty-two patients were included in this study, of which 87 (57.2%) were in Vitamin D insufficiency state while 60 (39.5%) were in Vitamin D deficiency state. Serum 25(OH)D levels of patients in Stage 4 and Stage 5 CKD were lower than that of patients in Stage 3 CKD (P = 0.002). It was discovered that female gender (odds ratio [OR] = 3.674; 95% confidence interval [CI], 1.607-8.396; P = 0.002), serum albumin level <30.0 g/L (OR = 6.816; 95% CI, 2.634-17.633; P < 0.001), and estimated glomerular filtration rate (eGFR) <30 ml/min/1.73 m2 (OR = 4.761; 95% CI, 1.353-16.754; P = 0.015) were independent predictors of Vitamin D deficiency.
Vitamin D insufficiency and deficiency are common in predialysis patients with Stage 3-5 CKD in Southern China. Female gender, hypoalbuminemia with serum albumin level <30.0 g/L, and severe damaged renal function with eGFR <30 ml/min/1.73 m2 are independent predictors of Vitamin D deficiency in predialysis patients with Stage 3-5 CKD.</description><identifier>ISSN: 1119-3077</identifier><identifier>DOI: 10.4103/njcp.njcp_27_17</identifier><identifier>PMID: 29192637</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Care and treatment ; Chronic kidney failure ; Diagnosis ; Glomerular filtration rate ; Health aspects ; Risk factors ; Vitamin D deficiency</subject><ispartof>Nigerian journal of clinical practice, 2017-10, Vol.20 (10), p.1309-1315</ispartof><rights>COPYRIGHT 2017 Medknow Publications and Media Pvt. Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-d23f2c78555dc08b0cd8821f49db2f75ccda0bd6f5c56a352726e339b06d75c23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29192637$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feng, M</creatorcontrib><creatorcontrib>Lv, J</creatorcontrib><creatorcontrib>Huang, F T</creatorcontrib><creatorcontrib>Liang, P F</creatorcontrib><creatorcontrib>Fu, S</creatorcontrib><creatorcontrib>Zeng, Y C</creatorcontrib><creatorcontrib>Tang, Y</creatorcontrib><creatorcontrib>Xu, A P</creatorcontrib><title>Predictors of Vitamin D deficiency in predialysis patients with stage 3-5 chronic kidney diseases in Southern China</title><title>Nigerian journal of clinical practice</title><addtitle>Niger J Clin Pract</addtitle><description>Vitamin D status and risk factors of Vitamin D deficiency in chronic kidney disease (CKD) patients in China have been seldom reported before. In this study, we aim to investigate serum 25-hydroxyvitamin D [25(OH)D] status and find the predictors of Vitamin D deficiency in predialysis patients with Stage 3-5 CKDs in Southern China.
In this retrospective cross-sectional study, hospitalized predialysis patients who were diagnosed of Stage 3-5 CKD and had taken measurement of serum 25(OH)D in a single center from January 2014 to June 2015 were included. Patients were divided into Vitamin D deficiency group and nondeficiency group depending on the cutoff serum 25(OH)D value of 37 nmol/L. Clinical and biochemical parameters were collected and evaluated for predictors of Vitamin D deficiency by logistic regression.
One hundred and fifty-two patients were included in this study, of which 87 (57.2%) were in Vitamin D insufficiency state while 60 (39.5%) were in Vitamin D deficiency state. Serum 25(OH)D levels of patients in Stage 4 and Stage 5 CKD were lower than that of patients in Stage 3 CKD (P = 0.002). It was discovered that female gender (odds ratio [OR] = 3.674; 95% confidence interval [CI], 1.607-8.396; P = 0.002), serum albumin level <30.0 g/L (OR = 6.816; 95% CI, 2.634-17.633; P < 0.001), and estimated glomerular filtration rate (eGFR) <30 ml/min/1.73 m2 (OR = 4.761; 95% CI, 1.353-16.754; P = 0.015) were independent predictors of Vitamin D deficiency.
Vitamin D insufficiency and deficiency are common in predialysis patients with Stage 3-5 CKD in Southern China. Female gender, hypoalbuminemia with serum albumin level <30.0 g/L, and severe damaged renal function with eGFR <30 ml/min/1.73 m2 are independent predictors of Vitamin D deficiency in predialysis patients with Stage 3-5 CKD.</description><subject>Care and treatment</subject><subject>Chronic kidney failure</subject><subject>Diagnosis</subject><subject>Glomerular filtration rate</subject><subject>Health aspects</subject><subject>Risk factors</subject><subject>Vitamin D deficiency</subject><issn>1119-3077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNptkdtrFTEQxvdBsbX67JsEBPFlT3PZbDaP5dRWoaDg5TVkc-mm7iZrJouc_95dT70UJDBhZn7fwMxXVS8I3jUEs_N4Z-bdFhQViohH1SkhRNYMC3FSPQW4w7iVrCNPqhMqiaQtE6cVfMzOBlNSBpQ8-hqKnkJEl8g6H0xw0RzQms8bpccDBECzLmu9APoRyoCg6FuHWM2RGXKKwaBvwUZ3QDaA0-Bgk39KSxlcjmg_hKifVY-9HsE9v__Pqi9Xbz_v39U3H67f7y9uasMkL7WlzFMjOs65NbjrsbFdR4lvpO2pF9wYq3FvW88NbzXjVNDWMSZ73Nq1S9lZ9eY4d87p--KgqCmAceOoo0sLKCIFaTlp2Ia-OqK3enQqRJ9K1mbD1QUnosGy65qV2v2HWp91UzApridb6w8Er_8RDE6PZYA0LiWkCA_B8yNocgLIzqs5h0nngyJYbe6qX8b-dXdVvLxfbuknZ__wv61lPwG9yaOy</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Feng, M</creator><creator>Lv, J</creator><creator>Huang, F T</creator><creator>Liang, P F</creator><creator>Fu, S</creator><creator>Zeng, Y C</creator><creator>Tang, Y</creator><creator>Xu, A P</creator><general>Medknow Publications and Media Pvt. Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20171001</creationdate><title>Predictors of Vitamin D deficiency in predialysis patients with stage 3-5 chronic kidney diseases in Southern China</title><author>Feng, M ; Lv, J ; Huang, F T ; Liang, P F ; Fu, S ; Zeng, Y C ; Tang, Y ; Xu, A P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-d23f2c78555dc08b0cd8821f49db2f75ccda0bd6f5c56a352726e339b06d75c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Care and treatment</topic><topic>Chronic kidney failure</topic><topic>Diagnosis</topic><topic>Glomerular filtration rate</topic><topic>Health aspects</topic><topic>Risk factors</topic><topic>Vitamin D deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feng, M</creatorcontrib><creatorcontrib>Lv, J</creatorcontrib><creatorcontrib>Huang, F T</creatorcontrib><creatorcontrib>Liang, P F</creatorcontrib><creatorcontrib>Fu, S</creatorcontrib><creatorcontrib>Zeng, Y C</creatorcontrib><creatorcontrib>Tang, Y</creatorcontrib><creatorcontrib>Xu, A P</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nigerian journal of clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, M</au><au>Lv, J</au><au>Huang, F T</au><au>Liang, P F</au><au>Fu, S</au><au>Zeng, Y C</au><au>Tang, Y</au><au>Xu, A P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of Vitamin D deficiency in predialysis patients with stage 3-5 chronic kidney diseases in Southern China</atitle><jtitle>Nigerian journal of clinical practice</jtitle><addtitle>Niger J Clin Pract</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>20</volume><issue>10</issue><spage>1309</spage><epage>1315</epage><pages>1309-1315</pages><issn>1119-3077</issn><abstract>Vitamin D status and risk factors of Vitamin D deficiency in chronic kidney disease (CKD) patients in China have been seldom reported before. In this study, we aim to investigate serum 25-hydroxyvitamin D [25(OH)D] status and find the predictors of Vitamin D deficiency in predialysis patients with Stage 3-5 CKDs in Southern China.
In this retrospective cross-sectional study, hospitalized predialysis patients who were diagnosed of Stage 3-5 CKD and had taken measurement of serum 25(OH)D in a single center from January 2014 to June 2015 were included. Patients were divided into Vitamin D deficiency group and nondeficiency group depending on the cutoff serum 25(OH)D value of 37 nmol/L. Clinical and biochemical parameters were collected and evaluated for predictors of Vitamin D deficiency by logistic regression.
One hundred and fifty-two patients were included in this study, of which 87 (57.2%) were in Vitamin D insufficiency state while 60 (39.5%) were in Vitamin D deficiency state. Serum 25(OH)D levels of patients in Stage 4 and Stage 5 CKD were lower than that of patients in Stage 3 CKD (P = 0.002). It was discovered that female gender (odds ratio [OR] = 3.674; 95% confidence interval [CI], 1.607-8.396; P = 0.002), serum albumin level <30.0 g/L (OR = 6.816; 95% CI, 2.634-17.633; P < 0.001), and estimated glomerular filtration rate (eGFR) <30 ml/min/1.73 m2 (OR = 4.761; 95% CI, 1.353-16.754; P = 0.015) were independent predictors of Vitamin D deficiency.
Vitamin D insufficiency and deficiency are common in predialysis patients with Stage 3-5 CKD in Southern China. Female gender, hypoalbuminemia with serum albumin level <30.0 g/L, and severe damaged renal function with eGFR <30 ml/min/1.73 m2 are independent predictors of Vitamin D deficiency in predialysis patients with Stage 3-5 CKD.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>29192637</pmid><doi>10.4103/njcp.njcp_27_17</doi><tpages>7</tpages></addata></record> |
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| source | African Journals Online (Open Access); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Care and treatment Chronic kidney failure Diagnosis Glomerular filtration rate Health aspects Risk factors Vitamin D deficiency |
| title | Predictors of Vitamin D deficiency in predialysis patients with stage 3-5 chronic kidney diseases in Southern China |
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