ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity
High-grade endometrial stromal sarcoma likely encompasses underrecognized tumors harboring genetic abnormalities besides YWHAE–NUTM2 fusion. Triggered by three initial endometrial stromal sarcomas with ZC3H7B–BCOR fusion characterized by high-grade morphology and aggressive clinical behavior, we her...
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| Veröffentlicht in: | Modern pathology 2018-04, Vol.31 (4), p.674-684 |
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| creator | Lewis, Natasha Soslow, Robert A Delair, Deborah F Park, Kay J Murali, Rajmohan Hollmann, Travis J Davidson, Ben Micci, Francesca Panagopoulos, Ioannis Hoang, Lien N Arias-Stella, Javier A Oliva, Esther Young, Robert H Hensley, Martee L Leitao, Mario M Hameed, Meera Benayed, Ryma Ladanyi, Marc Frosina, Denise Jungbluth, Achim A Antonescu, Cristina R Chiang, Sarah |
| description | High-grade endometrial stromal sarcoma likely encompasses underrecognized tumors harboring genetic abnormalities besides
YWHAE–NUTM2
fusion. Triggered by three initial endometrial stromal sarcomas with
ZC3H7B–BCOR
fusion characterized by high-grade morphology and aggressive clinical behavior, we herein investigate the clinicopathologic features of this genetic subset by expanding the analysis to 17 such tumors. All of them occurred in adult women with a median age of 54 (range, 28–71) years. They were predominantly based in the endomyometrium and demonstrated tongue-like and/or pushing myometrial invasion. Most were uniformly cellular and displayed haphazard fascicles of spindle cells with mild to moderate nuclear atypia. Myxoid matrix was seen in 14 of 17 (82%) tumors, and collagen plaques were seen in 8 (47%). The mitotic index was ≥10 mitotic figures/10 high-power fields (HPFs) in 14 of 17 (82%) tumors with a median of 14.5 mitotic figures/10 HPFs. No foci of conventional or variant low-grade endometrial stromal sarcoma were seen. All tumors expressed CD10 with only limited or absent desmin, SMA and/or h-caldesmon staining. ER and PR expression in >5% of cells was seen in 4 of 12 (33%) tumors. Diffuse cyclin D1 and BCOR immunoreactivity was present in 7 of 8 (88%) and 7 of 14 (50%) tumors, respectively. Fluorescence
in situ
hybridization or targeted RNA sequencing confirmed
ZC3H7B–BCOR
fusion in all tumors, including four and two previously diagnosed as myxoid leiomyosarcoma and undifferentiated uterine sarcoma, respectively. Limited clinical data suggest that patients present at higher stage and have worse prognosis compared with published outcomes in low-grade endometrial stromal sarcoma. Tumors with
ZC3H7B–BCOR
fusion constitute a distinct group of endometrial stromal sarcomas with high-grade morphology that should be distinguished from other uterine mesenchymal neoplasms that may demonstrate myxoid morphology. |
| doi_str_mv | 10.1038/modpathol.2017.162 |
| format | Article |
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YWHAE–NUTM2
fusion. Triggered by three initial endometrial stromal sarcomas with
ZC3H7B–BCOR
fusion characterized by high-grade morphology and aggressive clinical behavior, we herein investigate the clinicopathologic features of this genetic subset by expanding the analysis to 17 such tumors. All of them occurred in adult women with a median age of 54 (range, 28–71) years. They were predominantly based in the endomyometrium and demonstrated tongue-like and/or pushing myometrial invasion. Most were uniformly cellular and displayed haphazard fascicles of spindle cells with mild to moderate nuclear atypia. Myxoid matrix was seen in 14 of 17 (82%) tumors, and collagen plaques were seen in 8 (47%). The mitotic index was ≥10 mitotic figures/10 high-power fields (HPFs) in 14 of 17 (82%) tumors with a median of 14.5 mitotic figures/10 HPFs. No foci of conventional or variant low-grade endometrial stromal sarcoma were seen. All tumors expressed CD10 with only limited or absent desmin, SMA and/or h-caldesmon staining. ER and PR expression in >5% of cells was seen in 4 of 12 (33%) tumors. Diffuse cyclin D1 and BCOR immunoreactivity was present in 7 of 8 (88%) and 7 of 14 (50%) tumors, respectively. Fluorescence
in situ
hybridization or targeted RNA sequencing confirmed
ZC3H7B–BCOR
fusion in all tumors, including four and two previously diagnosed as myxoid leiomyosarcoma and undifferentiated uterine sarcoma, respectively. Limited clinical data suggest that patients present at higher stage and have worse prognosis compared with published outcomes in low-grade endometrial stromal sarcoma. Tumors with
ZC3H7B–BCOR
fusion constitute a distinct group of endometrial stromal sarcomas with high-grade morphology that should be distinguished from other uterine mesenchymal neoplasms that may demonstrate myxoid morphology.</description><identifier>ISSN: 0893-3952</identifier><identifier>EISSN: 1530-0285</identifier><identifier>DOI: 10.1038/modpathol.2017.162</identifier><identifier>PMID: 29192652</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/67/1517/1931 ; 692/699/67/1517/1931 ; Adult ; Aged ; Collagen ; Cyclin D1 ; Desmin ; Endometrial Neoplasms - genetics ; Endometrial Neoplasms - pathology ; Endometrium ; Female ; Fluorescence in situ hybridization ; Genetic analysis ; Humans ; Immunoreactivity ; Laboratory Medicine ; Medicine ; Medicine & Public Health ; Mesenchyme ; Middle Aged ; Morphology ; Myometrium ; Oncogene Proteins, Fusion - genetics ; original-article ; Pathology ; Plaques ; Proto-Oncogene Proteins - genetics ; Repressor Proteins - genetics ; Ribonucleic acid ; RNA ; RNA-Binding Proteins - genetics ; Sarcoma ; Sarcoma, Endometrial Stromal - genetics ; Sarcoma, Endometrial Stromal - pathology ; Tongue ; Tumors ; Uterus</subject><ispartof>Modern pathology, 2018-04, Vol.31 (4), p.674-684</ispartof><rights>United States & Canadian Academy of Pathology USCAP, Inc 2018</rights><rights>Copyright Nature Publishing Group Apr 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4282-208037220f75d1d1bed49376217f91d3675870fd4f2589041517e19a462d41d33</citedby><cites>FETCH-LOGICAL-c4282-208037220f75d1d1bed49376217f91d3675870fd4f2589041517e19a462d41d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29192652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lewis, Natasha</creatorcontrib><creatorcontrib>Soslow, Robert A</creatorcontrib><creatorcontrib>Delair, Deborah F</creatorcontrib><creatorcontrib>Park, Kay J</creatorcontrib><creatorcontrib>Murali, Rajmohan</creatorcontrib><creatorcontrib>Hollmann, Travis J</creatorcontrib><creatorcontrib>Davidson, Ben</creatorcontrib><creatorcontrib>Micci, Francesca</creatorcontrib><creatorcontrib>Panagopoulos, Ioannis</creatorcontrib><creatorcontrib>Hoang, Lien N</creatorcontrib><creatorcontrib>Arias-Stella, Javier A</creatorcontrib><creatorcontrib>Oliva, Esther</creatorcontrib><creatorcontrib>Young, Robert H</creatorcontrib><creatorcontrib>Hensley, Martee L</creatorcontrib><creatorcontrib>Leitao, Mario M</creatorcontrib><creatorcontrib>Hameed, Meera</creatorcontrib><creatorcontrib>Benayed, Ryma</creatorcontrib><creatorcontrib>Ladanyi, Marc</creatorcontrib><creatorcontrib>Frosina, Denise</creatorcontrib><creatorcontrib>Jungbluth, Achim A</creatorcontrib><creatorcontrib>Antonescu, Cristina R</creatorcontrib><creatorcontrib>Chiang, Sarah</creatorcontrib><title>ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity</title><title>Modern pathology</title><addtitle>Mod Pathol</addtitle><addtitle>Mod Pathol</addtitle><description>High-grade endometrial stromal sarcoma likely encompasses underrecognized tumors harboring genetic abnormalities besides
YWHAE–NUTM2
fusion. Triggered by three initial endometrial stromal sarcomas with
ZC3H7B–BCOR
fusion characterized by high-grade morphology and aggressive clinical behavior, we herein investigate the clinicopathologic features of this genetic subset by expanding the analysis to 17 such tumors. All of them occurred in adult women with a median age of 54 (range, 28–71) years. They were predominantly based in the endomyometrium and demonstrated tongue-like and/or pushing myometrial invasion. Most were uniformly cellular and displayed haphazard fascicles of spindle cells with mild to moderate nuclear atypia. Myxoid matrix was seen in 14 of 17 (82%) tumors, and collagen plaques were seen in 8 (47%). The mitotic index was ≥10 mitotic figures/10 high-power fields (HPFs) in 14 of 17 (82%) tumors with a median of 14.5 mitotic figures/10 HPFs. No foci of conventional or variant low-grade endometrial stromal sarcoma were seen. All tumors expressed CD10 with only limited or absent desmin, SMA and/or h-caldesmon staining. ER and PR expression in >5% of cells was seen in 4 of 12 (33%) tumors. Diffuse cyclin D1 and BCOR immunoreactivity was present in 7 of 8 (88%) and 7 of 14 (50%) tumors, respectively. Fluorescence
in situ
hybridization or targeted RNA sequencing confirmed
ZC3H7B–BCOR
fusion in all tumors, including four and two previously diagnosed as myxoid leiomyosarcoma and undifferentiated uterine sarcoma, respectively. Limited clinical data suggest that patients present at higher stage and have worse prognosis compared with published outcomes in low-grade endometrial stromal sarcoma. Tumors with
ZC3H7B–BCOR
fusion constitute a distinct group of endometrial stromal sarcomas with high-grade morphology that should be distinguished from other uterine mesenchymal neoplasms that may demonstrate myxoid morphology.</description><subject>631/67/1517/1931</subject><subject>692/699/67/1517/1931</subject><subject>Adult</subject><subject>Aged</subject><subject>Collagen</subject><subject>Cyclin D1</subject><subject>Desmin</subject><subject>Endometrial Neoplasms - genetics</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Endometrium</subject><subject>Female</subject><subject>Fluorescence in situ hybridization</subject><subject>Genetic analysis</subject><subject>Humans</subject><subject>Immunoreactivity</subject><subject>Laboratory Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mesenchyme</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Myometrium</subject><subject>Oncogene Proteins, Fusion - genetics</subject><subject>original-article</subject><subject>Pathology</subject><subject>Plaques</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Repressor Proteins - genetics</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA-Binding Proteins - genetics</subject><subject>Sarcoma</subject><subject>Sarcoma, Endometrial Stromal - genetics</subject><subject>Sarcoma, Endometrial Stromal - pathology</subject><subject>Tongue</subject><subject>Tumors</subject><subject>Uterus</subject><issn>0893-3952</issn><issn>1530-0285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kcFq3DAQhkVpaDZpX6CHIuilF280I8myemuWNikEAqW99CIUa7zrYFtbyUvZt6-WTRPIIacZmG9-DfoYew9iCUI2F2MMWz9v4rBEAWYJNb5iC9BSVAIb_ZotRGNlJa3GU3aW870QoHSDb9gpWrBYa1yw9vdKXpvL6nJ1-4Nv-vWmWicfiNMU4khz6v3A85zieKg-taXJn7nnibYxzTx2HAxvfaZ86D2f6O-w54G6fqJQUuZ-3r9lJ50fMr17qOfs17evP1fX1c3t1ffVl5uqVdhghaIR0iCKzugAAe4oKCtNjWA6C0HWRjdGdEF1qBsrFGgwBNarGoMqc3nOPh1ztyn-2VGe3djnlobBTxR32YE1UCuDShX04zP0Pu7SVK5zKKUQ2igjX6QE1uVnja0LhUeqTTHnRJ3bpn70ae9AuIMo9yjKHUS5IqosfXiI3t2NFB5X_pspgDwCuYymNaWnt1-I_QeSjJ2o</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Lewis, Natasha</creator><creator>Soslow, Robert A</creator><creator>Delair, Deborah F</creator><creator>Park, Kay J</creator><creator>Murali, Rajmohan</creator><creator>Hollmann, Travis J</creator><creator>Davidson, Ben</creator><creator>Micci, Francesca</creator><creator>Panagopoulos, Ioannis</creator><creator>Hoang, Lien N</creator><creator>Arias-Stella, Javier A</creator><creator>Oliva, Esther</creator><creator>Young, Robert H</creator><creator>Hensley, Martee L</creator><creator>Leitao, Mario M</creator><creator>Hameed, Meera</creator><creator>Benayed, Ryma</creator><creator>Ladanyi, Marc</creator><creator>Frosina, Denise</creator><creator>Jungbluth, Achim A</creator><creator>Antonescu, Cristina R</creator><creator>Chiang, Sarah</creator><general>Nature Publishing Group US</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20180401</creationdate><title>ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity</title><author>Lewis, Natasha ; Soslow, Robert A ; Delair, Deborah F ; Park, Kay J ; Murali, Rajmohan ; Hollmann, Travis J ; Davidson, Ben ; Micci, Francesca ; Panagopoulos, Ioannis ; Hoang, Lien N ; Arias-Stella, Javier A ; Oliva, Esther ; Young, Robert H ; Hensley, Martee L ; Leitao, Mario M ; Hameed, Meera ; Benayed, Ryma ; Ladanyi, Marc ; Frosina, Denise ; Jungbluth, Achim A ; Antonescu, Cristina R ; Chiang, Sarah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4282-208037220f75d1d1bed49376217f91d3675870fd4f2589041517e19a462d41d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>631/67/1517/1931</topic><topic>692/699/67/1517/1931</topic><topic>Adult</topic><topic>Aged</topic><topic>Collagen</topic><topic>Cyclin D1</topic><topic>Desmin</topic><topic>Endometrial Neoplasms - genetics</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Endometrium</topic><topic>Female</topic><topic>Fluorescence in situ hybridization</topic><topic>Genetic analysis</topic><topic>Humans</topic><topic>Immunoreactivity</topic><topic>Laboratory Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mesenchyme</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>Myometrium</topic><topic>Oncogene Proteins, Fusion - genetics</topic><topic>original-article</topic><topic>Pathology</topic><topic>Plaques</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Repressor Proteins - genetics</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA-Binding Proteins - genetics</topic><topic>Sarcoma</topic><topic>Sarcoma, Endometrial Stromal - genetics</topic><topic>Sarcoma, Endometrial Stromal - pathology</topic><topic>Tongue</topic><topic>Tumors</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lewis, Natasha</creatorcontrib><creatorcontrib>Soslow, Robert A</creatorcontrib><creatorcontrib>Delair, Deborah F</creatorcontrib><creatorcontrib>Park, Kay J</creatorcontrib><creatorcontrib>Murali, Rajmohan</creatorcontrib><creatorcontrib>Hollmann, Travis J</creatorcontrib><creatorcontrib>Davidson, Ben</creatorcontrib><creatorcontrib>Micci, Francesca</creatorcontrib><creatorcontrib>Panagopoulos, Ioannis</creatorcontrib><creatorcontrib>Hoang, Lien N</creatorcontrib><creatorcontrib>Arias-Stella, Javier A</creatorcontrib><creatorcontrib>Oliva, Esther</creatorcontrib><creatorcontrib>Young, Robert H</creatorcontrib><creatorcontrib>Hensley, Martee L</creatorcontrib><creatorcontrib>Leitao, Mario M</creatorcontrib><creatorcontrib>Hameed, Meera</creatorcontrib><creatorcontrib>Benayed, Ryma</creatorcontrib><creatorcontrib>Ladanyi, Marc</creatorcontrib><creatorcontrib>Frosina, Denise</creatorcontrib><creatorcontrib>Jungbluth, Achim A</creatorcontrib><creatorcontrib>Antonescu, Cristina R</creatorcontrib><creatorcontrib>Chiang, Sarah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Modern pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lewis, Natasha</au><au>Soslow, Robert A</au><au>Delair, Deborah F</au><au>Park, Kay J</au><au>Murali, Rajmohan</au><au>Hollmann, Travis J</au><au>Davidson, Ben</au><au>Micci, Francesca</au><au>Panagopoulos, Ioannis</au><au>Hoang, Lien N</au><au>Arias-Stella, Javier A</au><au>Oliva, Esther</au><au>Young, Robert H</au><au>Hensley, Martee L</au><au>Leitao, Mario M</au><au>Hameed, Meera</au><au>Benayed, Ryma</au><au>Ladanyi, Marc</au><au>Frosina, Denise</au><au>Jungbluth, Achim A</au><au>Antonescu, Cristina R</au><au>Chiang, Sarah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity</atitle><jtitle>Modern pathology</jtitle><stitle>Mod Pathol</stitle><addtitle>Mod Pathol</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>31</volume><issue>4</issue><spage>674</spage><epage>684</epage><pages>674-684</pages><issn>0893-3952</issn><eissn>1530-0285</eissn><abstract>High-grade endometrial stromal sarcoma likely encompasses underrecognized tumors harboring genetic abnormalities besides
YWHAE–NUTM2
fusion. Triggered by three initial endometrial stromal sarcomas with
ZC3H7B–BCOR
fusion characterized by high-grade morphology and aggressive clinical behavior, we herein investigate the clinicopathologic features of this genetic subset by expanding the analysis to 17 such tumors. All of them occurred in adult women with a median age of 54 (range, 28–71) years. They were predominantly based in the endomyometrium and demonstrated tongue-like and/or pushing myometrial invasion. Most were uniformly cellular and displayed haphazard fascicles of spindle cells with mild to moderate nuclear atypia. Myxoid matrix was seen in 14 of 17 (82%) tumors, and collagen plaques were seen in 8 (47%). The mitotic index was ≥10 mitotic figures/10 high-power fields (HPFs) in 14 of 17 (82%) tumors with a median of 14.5 mitotic figures/10 HPFs. No foci of conventional or variant low-grade endometrial stromal sarcoma were seen. All tumors expressed CD10 with only limited or absent desmin, SMA and/or h-caldesmon staining. ER and PR expression in >5% of cells was seen in 4 of 12 (33%) tumors. Diffuse cyclin D1 and BCOR immunoreactivity was present in 7 of 8 (88%) and 7 of 14 (50%) tumors, respectively. Fluorescence
in situ
hybridization or targeted RNA sequencing confirmed
ZC3H7B–BCOR
fusion in all tumors, including four and two previously diagnosed as myxoid leiomyosarcoma and undifferentiated uterine sarcoma, respectively. Limited clinical data suggest that patients present at higher stage and have worse prognosis compared with published outcomes in low-grade endometrial stromal sarcoma. Tumors with
ZC3H7B–BCOR
fusion constitute a distinct group of endometrial stromal sarcomas with high-grade morphology that should be distinguished from other uterine mesenchymal neoplasms that may demonstrate myxoid morphology.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>29192652</pmid><doi>10.1038/modpathol.2017.162</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0893-3952 |
| ispartof | Modern pathology, 2018-04, Vol.31 (4), p.674-684 |
| issn | 0893-3952 1530-0285 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1971647244 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 631/67/1517/1931 692/699/67/1517/1931 Adult Aged Collagen Cyclin D1 Desmin Endometrial Neoplasms - genetics Endometrial Neoplasms - pathology Endometrium Female Fluorescence in situ hybridization Genetic analysis Humans Immunoreactivity Laboratory Medicine Medicine Medicine & Public Health Mesenchyme Middle Aged Morphology Myometrium Oncogene Proteins, Fusion - genetics original-article Pathology Plaques Proto-Oncogene Proteins - genetics Repressor Proteins - genetics Ribonucleic acid RNA RNA-Binding Proteins - genetics Sarcoma Sarcoma, Endometrial Stromal - genetics Sarcoma, Endometrial Stromal - pathology Tongue Tumors Uterus |
| title | ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T15%3A20%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=ZC3H7B-BCOR%20high-grade%20endometrial%20stromal%20sarcomas:%20a%20report%20of%2017%20cases%20of%20a%20newly%20defined%20entity&rft.jtitle=Modern%20pathology&rft.au=Lewis,%20Natasha&rft.date=2018-04-01&rft.volume=31&rft.issue=4&rft.spage=674&rft.epage=684&rft.pages=674-684&rft.issn=0893-3952&rft.eissn=1530-0285&rft_id=info:doi/10.1038/modpathol.2017.162&rft_dat=%3Cproquest_cross%3E2026395796%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2026395796&rft_id=info:pmid/29192652&rfr_iscdi=true |