Live‐Cell Protein Sulfonylation Based on Proximity‐driven N‐Sulfonyl Pyridone Chemistry

The development of bioorthogonal approaches for labeling of endogenous proteins under the multimolecular crowding conditions of live cells is highly desirable for the analysis and engineering of proteins without using genetic manipulation. N‐Sulfonyl pyridone (SP) is reported as a new reactive group...

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Veröffentlicht in:	Angewandte Chemie International Edition 2018-01, Vol.57 (3), p.659-662
Hauptverfasser:	Matsuo, Kazuya, Nishikawa, Yuki, Masuda, Marie, Hamachi, Itaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosensors Fluorescence resonance energy transfer FRET biosensors intracellular protein labeling N-sulfonyl pyridones Proteins traceless affinity sulfonylation
Online-Zugang:	Volltext
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