Group for Research and Assessment of Psoriasis and Psoriatic Arthritis/Outcome Measures in Rheumatology Consensus‐Based Recommendations and Research Agenda for Use of Composite Measures and Treatment Targets in Psoriatic Arthritis

Objective A meeting was convened by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and Outcome Measures in Rheumatology (OMERACT) to further the development of consensus among physicians and patients regarding composite disease activity measures and targets in ps...

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Veröffentlicht in:Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2018-03, Vol.70 (3), p.345-355
Hauptverfasser: Coates, Laura C., FitzGerald, Oliver, Merola, Joseph F., Smolen, Josef, Mens, Leonieke J. J., Bertheussen, Heidi, Boehncke, Wolf‐Henning, Callis Duffin, Kristina, Campbell, Willemina, Wit, Maarten, Gladman, Dafna, Gottlieb, Alice, James, Jana, Kavanaugh, Arthur, Kristensen, Lars Erik, Kvien, Tore K., Luger, Thomas, McHugh, Neil, Mease, Philip, Nash, Peter, Ogdie, Alexis, Rosen, Cheryl F., Strand, Vibeke, Tillett, William, Veale, Douglas J., Helliwell, Philip S.
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container_issue 3
container_start_page 345
container_title Arthritis & rheumatology (Hoboken, N.J.)
container_volume 70
creator Coates, Laura C.
FitzGerald, Oliver
Merola, Joseph F.
Smolen, Josef
Mens, Leonieke J. J.
Bertheussen, Heidi
Boehncke, Wolf‐Henning
Callis Duffin, Kristina
Campbell, Willemina
Wit, Maarten
Gladman, Dafna
Gottlieb, Alice
James, Jana
Kavanaugh, Arthur
Kristensen, Lars Erik
Kvien, Tore K.
Luger, Thomas
McHugh, Neil
Mease, Philip
Nash, Peter
Ogdie, Alexis
Rosen, Cheryl F.
Strand, Vibeke
Tillett, William
Veale, Douglas J.
Helliwell, Philip S.
description Objective A meeting was convened by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and Outcome Measures in Rheumatology (OMERACT) to further the development of consensus among physicians and patients regarding composite disease activity measures and targets in psoriatic arthritis (PsA). Methods Prior to the meeting, physicians and patients completed surveys on outcome measures. A consensus meeting of 26 rheumatologists, dermatologists, and patient research partners reviewed evidence on composite measures and potential treatment targets plus results of the surveys. The meeting consisted of plenary presentations, breakout sessions, and group discussions. International experts including members of GRAPPA and OMERACT were invited to the meeting, including the developers of all of the measures discussed. After discussions, participants voted on proposals for use, and consensus was established in a second survey. Results Survey results from 128 health care professionals and 139 patients were analyzed alongside a systematic literature review summarizing evidence. A weighted vote was cast for composite measures. For randomized controlled trials, the most popular measures were the PsA disease activity score (40 votes) and the GRAPPA composite index (28 votes). For clinical practice, the most popular measures were an average of scores on 3 visual analog scales (45 votes) and the disease activity in PsA score (26 votes). After discussion, there was no consensus on a composite measure. The group agreed that several composite measures could be used and that future studies should allow further validation and comparison. The group unanimously agreed that remission should be the ideal target, with minimal disease activity (MDA)/low disease activity as a feasible alternative. The target should include assessment of musculoskeletal disease, skin disease, and health‐related quality of life. The group recommended a treatment target of very low disease activity (VLDA) or MDA. Conclusion Consensus was not reached on a continuous measure of disease activity. In the interim, the group recommended several composites. Consensus was reached on a treatment target of VLDA/MDA. An extensive research agenda was composed and recommends that data on all PsA clinical domains be collected in ongoing studies.
doi_str_mv 10.1002/art.40391
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J. ; Bertheussen, Heidi ; Boehncke, Wolf‐Henning ; Callis Duffin, Kristina ; Campbell, Willemina ; Wit, Maarten ; Gladman, Dafna ; Gottlieb, Alice ; James, Jana ; Kavanaugh, Arthur ; Kristensen, Lars Erik ; Kvien, Tore K. ; Luger, Thomas ; McHugh, Neil ; Mease, Philip ; Nash, Peter ; Ogdie, Alexis ; Rosen, Cheryl F. ; Strand, Vibeke ; Tillett, William ; Veale, Douglas J. ; Helliwell, Philip S.</creator><creatorcontrib>Coates, Laura C. ; FitzGerald, Oliver ; Merola, Joseph F. ; Smolen, Josef ; Mens, Leonieke J. J. ; Bertheussen, Heidi ; Boehncke, Wolf‐Henning ; Callis Duffin, Kristina ; Campbell, Willemina ; Wit, Maarten ; Gladman, Dafna ; Gottlieb, Alice ; James, Jana ; Kavanaugh, Arthur ; Kristensen, Lars Erik ; Kvien, Tore K. ; Luger, Thomas ; McHugh, Neil ; Mease, Philip ; Nash, Peter ; Ogdie, Alexis ; Rosen, Cheryl F. ; Strand, Vibeke ; Tillett, William ; Veale, Douglas J. ; Helliwell, Philip S.</creatorcontrib><description>Objective A meeting was convened by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and Outcome Measures in Rheumatology (OMERACT) to further the development of consensus among physicians and patients regarding composite disease activity measures and targets in psoriatic arthritis (PsA). Methods Prior to the meeting, physicians and patients completed surveys on outcome measures. A consensus meeting of 26 rheumatologists, dermatologists, and patient research partners reviewed evidence on composite measures and potential treatment targets plus results of the surveys. The meeting consisted of plenary presentations, breakout sessions, and group discussions. International experts including members of GRAPPA and OMERACT were invited to the meeting, including the developers of all of the measures discussed. After discussions, participants voted on proposals for use, and consensus was established in a second survey. Results Survey results from 128 health care professionals and 139 patients were analyzed alongside a systematic literature review summarizing evidence. A weighted vote was cast for composite measures. For randomized controlled trials, the most popular measures were the PsA disease activity score (40 votes) and the GRAPPA composite index (28 votes). For clinical practice, the most popular measures were an average of scores on 3 visual analog scales (45 votes) and the disease activity in PsA score (26 votes). After discussion, there was no consensus on a composite measure. The group agreed that several composite measures could be used and that future studies should allow further validation and comparison. The group unanimously agreed that remission should be the ideal target, with minimal disease activity (MDA)/low disease activity as a feasible alternative. The target should include assessment of musculoskeletal disease, skin disease, and health‐related quality of life. The group recommended a treatment target of very low disease activity (VLDA) or MDA. Conclusion Consensus was not reached on a continuous measure of disease activity. In the interim, the group recommended several composites. Consensus was reached on a treatment target of VLDA/MDA. An extensive research agenda was composed and recommends that data on all PsA clinical domains be collected in ongoing studies.</description><identifier>ISSN: 2326-5191</identifier><identifier>EISSN: 2326-5205</identifier><identifier>DOI: 10.1002/art.40391</identifier><identifier>PMID: 29193765</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Arthritis ; Arthritis, Psoriatic - diagnosis ; Arthritis, Psoriatic - drug therapy ; Biomedical Research ; Clinical trials ; Consensus ; Disease control ; Feasibility studies ; Health care ; Humans ; Literature reviews ; Medical personnel ; Medical treatment ; Musculoskeletal diseases ; Outcome Assessment, Health Care - methods ; Pain Measurement ; Patients ; Physicians ; Polls &amp; surveys ; Psoriasis ; Psoriatic arthritis ; Quality of Life ; Remission ; Rheumatology ; Severity of Illness Index ; Skin diseases ; Surveys and Questionnaires ; Therapeutic applications</subject><ispartof>Arthritis &amp; rheumatology (Hoboken, N.J.), 2018-03, Vol.70 (3), p.345-355</ispartof><rights>2017, American College of Rheumatology</rights><rights>2017, American College of Rheumatology.</rights><rights>2018, American College of Rheumatology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3881-90beb6d6ab3b630c2e6ea758b57d00aa9117781ead7e4734e6286c441271b413</citedby><cites>FETCH-LOGICAL-c3881-90beb6d6ab3b630c2e6ea758b57d00aa9117781ead7e4734e6286c441271b413</cites><orcidid>0000-0002-4756-663X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.40391$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.40391$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29193765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coates, Laura C.</creatorcontrib><creatorcontrib>FitzGerald, Oliver</creatorcontrib><creatorcontrib>Merola, Joseph F.</creatorcontrib><creatorcontrib>Smolen, Josef</creatorcontrib><creatorcontrib>Mens, Leonieke J. J.</creatorcontrib><creatorcontrib>Bertheussen, Heidi</creatorcontrib><creatorcontrib>Boehncke, Wolf‐Henning</creatorcontrib><creatorcontrib>Callis Duffin, Kristina</creatorcontrib><creatorcontrib>Campbell, Willemina</creatorcontrib><creatorcontrib>Wit, Maarten</creatorcontrib><creatorcontrib>Gladman, Dafna</creatorcontrib><creatorcontrib>Gottlieb, Alice</creatorcontrib><creatorcontrib>James, Jana</creatorcontrib><creatorcontrib>Kavanaugh, Arthur</creatorcontrib><creatorcontrib>Kristensen, Lars Erik</creatorcontrib><creatorcontrib>Kvien, Tore K.</creatorcontrib><creatorcontrib>Luger, Thomas</creatorcontrib><creatorcontrib>McHugh, Neil</creatorcontrib><creatorcontrib>Mease, Philip</creatorcontrib><creatorcontrib>Nash, Peter</creatorcontrib><creatorcontrib>Ogdie, Alexis</creatorcontrib><creatorcontrib>Rosen, Cheryl F.</creatorcontrib><creatorcontrib>Strand, Vibeke</creatorcontrib><creatorcontrib>Tillett, William</creatorcontrib><creatorcontrib>Veale, Douglas J.</creatorcontrib><creatorcontrib>Helliwell, Philip S.</creatorcontrib><title>Group for Research and Assessment of Psoriasis and Psoriatic Arthritis/Outcome Measures in Rheumatology Consensus‐Based Recommendations and Research Agenda for Use of Composite Measures and Treatment Targets in Psoriatic Arthritis</title><title>Arthritis &amp; rheumatology (Hoboken, N.J.)</title><addtitle>Arthritis Rheumatol</addtitle><description>Objective A meeting was convened by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and Outcome Measures in Rheumatology (OMERACT) to further the development of consensus among physicians and patients regarding composite disease activity measures and targets in psoriatic arthritis (PsA). Methods Prior to the meeting, physicians and patients completed surveys on outcome measures. A consensus meeting of 26 rheumatologists, dermatologists, and patient research partners reviewed evidence on composite measures and potential treatment targets plus results of the surveys. The meeting consisted of plenary presentations, breakout sessions, and group discussions. International experts including members of GRAPPA and OMERACT were invited to the meeting, including the developers of all of the measures discussed. After discussions, participants voted on proposals for use, and consensus was established in a second survey. Results Survey results from 128 health care professionals and 139 patients were analyzed alongside a systematic literature review summarizing evidence. A weighted vote was cast for composite measures. For randomized controlled trials, the most popular measures were the PsA disease activity score (40 votes) and the GRAPPA composite index (28 votes). For clinical practice, the most popular measures were an average of scores on 3 visual analog scales (45 votes) and the disease activity in PsA score (26 votes). After discussion, there was no consensus on a composite measure. The group agreed that several composite measures could be used and that future studies should allow further validation and comparison. The group unanimously agreed that remission should be the ideal target, with minimal disease activity (MDA)/low disease activity as a feasible alternative. The target should include assessment of musculoskeletal disease, skin disease, and health‐related quality of life. The group recommended a treatment target of very low disease activity (VLDA) or MDA. Conclusion Consensus was not reached on a continuous measure of disease activity. In the interim, the group recommended several composites. Consensus was reached on a treatment target of VLDA/MDA. An extensive research agenda was composed and recommends that data on all PsA clinical domains be collected in ongoing studies.</description><subject>Arthritis</subject><subject>Arthritis, Psoriatic - diagnosis</subject><subject>Arthritis, Psoriatic - drug therapy</subject><subject>Biomedical Research</subject><subject>Clinical trials</subject><subject>Consensus</subject><subject>Disease control</subject><subject>Feasibility studies</subject><subject>Health care</subject><subject>Humans</subject><subject>Literature reviews</subject><subject>Medical personnel</subject><subject>Medical treatment</subject><subject>Musculoskeletal diseases</subject><subject>Outcome Assessment, Health Care - methods</subject><subject>Pain Measurement</subject><subject>Patients</subject><subject>Physicians</subject><subject>Polls &amp; surveys</subject><subject>Psoriasis</subject><subject>Psoriatic arthritis</subject><subject>Quality of Life</subject><subject>Remission</subject><subject>Rheumatology</subject><subject>Severity of Illness Index</subject><subject>Skin diseases</subject><subject>Surveys and Questionnaires</subject><subject>Therapeutic applications</subject><issn>2326-5191</issn><issn>2326-5205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ksFq3DAQhk1paUKSQ1-gCHppD5uVLFuyju7SpIWElMU9G9me3VWwra1GJuytj9BnzKmPUdlOQimJLtIw3_z_D5ooesfoOaM0XmrnzxPKFXsVHcc8Fos0punrxzdT7Cg6Q7yl4ShJBU3fRkexYopLkR5Hfy6dHfZkYx1ZA4J29Y7oviE5IiB20HtiN-Q7Wmc0Gpx6c-VNTXLnd854g8ubwde2A3INGgcHSExP1jsYOu1ta7cHsrI9Qo8D3v_6_VkjNMEvTASHJkiF5iT9lCHfjo0p1w-EMcPKdnuLxv_jMU4UDrSfchbabcFPzs8kPI3ebHSLcPZwn0TFxZdi9XVxdXP5bZVfLWqeZWyhaAWVaISueCU4rWMQoGWaValsKNVaMSZlxkA3EhLJExBxJuokYbFkVcL4SfRxlt07-3MA9GVnsIa21T3YAUumJBMJF0oE9MN_6K0dXB_ClTGlUjGRpaPgp5mqnUV0sCn3znTaHUpGy3EByrAA5bQAgX3_oDhUHTRP5ON3B2A5A3emhcPLSmW-LmbJv5Iiv5U</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Coates, Laura C.</creator><creator>FitzGerald, Oliver</creator><creator>Merola, Joseph F.</creator><creator>Smolen, Josef</creator><creator>Mens, Leonieke J. J.</creator><creator>Bertheussen, Heidi</creator><creator>Boehncke, Wolf‐Henning</creator><creator>Callis Duffin, Kristina</creator><creator>Campbell, Willemina</creator><creator>Wit, Maarten</creator><creator>Gladman, Dafna</creator><creator>Gottlieb, Alice</creator><creator>James, Jana</creator><creator>Kavanaugh, Arthur</creator><creator>Kristensen, Lars Erik</creator><creator>Kvien, Tore K.</creator><creator>Luger, Thomas</creator><creator>McHugh, Neil</creator><creator>Mease, Philip</creator><creator>Nash, Peter</creator><creator>Ogdie, Alexis</creator><creator>Rosen, Cheryl F.</creator><creator>Strand, Vibeke</creator><creator>Tillett, William</creator><creator>Veale, Douglas J.</creator><creator>Helliwell, Philip S.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4756-663X</orcidid></search><sort><creationdate>201803</creationdate><title>Group for Research and Assessment of Psoriasis and Psoriatic Arthritis/Outcome Measures in Rheumatology Consensus‐Based Recommendations and Research Agenda for Use of Composite Measures and Treatment Targets in Psoriatic Arthritis</title><author>Coates, Laura C. ; FitzGerald, Oliver ; Merola, Joseph F. ; Smolen, Josef ; Mens, Leonieke J. J. ; Bertheussen, Heidi ; Boehncke, Wolf‐Henning ; Callis Duffin, Kristina ; Campbell, Willemina ; Wit, Maarten ; Gladman, Dafna ; Gottlieb, Alice ; James, Jana ; Kavanaugh, Arthur ; Kristensen, Lars Erik ; Kvien, Tore K. ; Luger, Thomas ; McHugh, Neil ; Mease, Philip ; Nash, Peter ; Ogdie, Alexis ; Rosen, Cheryl F. ; Strand, Vibeke ; Tillett, William ; Veale, Douglas J. ; Helliwell, Philip S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3881-90beb6d6ab3b630c2e6ea758b57d00aa9117781ead7e4734e6286c441271b413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Arthritis</topic><topic>Arthritis, Psoriatic - diagnosis</topic><topic>Arthritis, Psoriatic - drug therapy</topic><topic>Biomedical Research</topic><topic>Clinical trials</topic><topic>Consensus</topic><topic>Disease control</topic><topic>Feasibility studies</topic><topic>Health care</topic><topic>Humans</topic><topic>Literature reviews</topic><topic>Medical personnel</topic><topic>Medical treatment</topic><topic>Musculoskeletal diseases</topic><topic>Outcome Assessment, Health Care - methods</topic><topic>Pain Measurement</topic><topic>Patients</topic><topic>Physicians</topic><topic>Polls &amp; surveys</topic><topic>Psoriasis</topic><topic>Psoriatic arthritis</topic><topic>Quality of Life</topic><topic>Remission</topic><topic>Rheumatology</topic><topic>Severity of Illness Index</topic><topic>Skin diseases</topic><topic>Surveys and Questionnaires</topic><topic>Therapeutic applications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coates, Laura C.</creatorcontrib><creatorcontrib>FitzGerald, Oliver</creatorcontrib><creatorcontrib>Merola, Joseph F.</creatorcontrib><creatorcontrib>Smolen, Josef</creatorcontrib><creatorcontrib>Mens, Leonieke J. J.</creatorcontrib><creatorcontrib>Bertheussen, Heidi</creatorcontrib><creatorcontrib>Boehncke, Wolf‐Henning</creatorcontrib><creatorcontrib>Callis Duffin, Kristina</creatorcontrib><creatorcontrib>Campbell, Willemina</creatorcontrib><creatorcontrib>Wit, Maarten</creatorcontrib><creatorcontrib>Gladman, Dafna</creatorcontrib><creatorcontrib>Gottlieb, Alice</creatorcontrib><creatorcontrib>James, Jana</creatorcontrib><creatorcontrib>Kavanaugh, Arthur</creatorcontrib><creatorcontrib>Kristensen, Lars Erik</creatorcontrib><creatorcontrib>Kvien, Tore K.</creatorcontrib><creatorcontrib>Luger, Thomas</creatorcontrib><creatorcontrib>McHugh, Neil</creatorcontrib><creatorcontrib>Mease, Philip</creatorcontrib><creatorcontrib>Nash, Peter</creatorcontrib><creatorcontrib>Ogdie, Alexis</creatorcontrib><creatorcontrib>Rosen, Cheryl F.</creatorcontrib><creatorcontrib>Strand, Vibeke</creatorcontrib><creatorcontrib>Tillett, William</creatorcontrib><creatorcontrib>Veale, Douglas J.</creatorcontrib><creatorcontrib>Helliwell, Philip S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis &amp; rheumatology (Hoboken, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coates, Laura C.</au><au>FitzGerald, Oliver</au><au>Merola, Joseph F.</au><au>Smolen, Josef</au><au>Mens, Leonieke J. J.</au><au>Bertheussen, Heidi</au><au>Boehncke, Wolf‐Henning</au><au>Callis Duffin, Kristina</au><au>Campbell, Willemina</au><au>Wit, Maarten</au><au>Gladman, Dafna</au><au>Gottlieb, Alice</au><au>James, Jana</au><au>Kavanaugh, Arthur</au><au>Kristensen, Lars Erik</au><au>Kvien, Tore K.</au><au>Luger, Thomas</au><au>McHugh, Neil</au><au>Mease, Philip</au><au>Nash, Peter</au><au>Ogdie, Alexis</au><au>Rosen, Cheryl F.</au><au>Strand, Vibeke</au><au>Tillett, William</au><au>Veale, Douglas J.</au><au>Helliwell, Philip S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Group for Research and Assessment of Psoriasis and Psoriatic Arthritis/Outcome Measures in Rheumatology Consensus‐Based Recommendations and Research Agenda for Use of Composite Measures and Treatment Targets in Psoriatic Arthritis</atitle><jtitle>Arthritis &amp; rheumatology (Hoboken, N.J.)</jtitle><addtitle>Arthritis Rheumatol</addtitle><date>2018-03</date><risdate>2018</risdate><volume>70</volume><issue>3</issue><spage>345</spage><epage>355</epage><pages>345-355</pages><issn>2326-5191</issn><eissn>2326-5205</eissn><abstract>Objective A meeting was convened by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and Outcome Measures in Rheumatology (OMERACT) to further the development of consensus among physicians and patients regarding composite disease activity measures and targets in psoriatic arthritis (PsA). Methods Prior to the meeting, physicians and patients completed surveys on outcome measures. A consensus meeting of 26 rheumatologists, dermatologists, and patient research partners reviewed evidence on composite measures and potential treatment targets plus results of the surveys. The meeting consisted of plenary presentations, breakout sessions, and group discussions. International experts including members of GRAPPA and OMERACT were invited to the meeting, including the developers of all of the measures discussed. After discussions, participants voted on proposals for use, and consensus was established in a second survey. Results Survey results from 128 health care professionals and 139 patients were analyzed alongside a systematic literature review summarizing evidence. A weighted vote was cast for composite measures. For randomized controlled trials, the most popular measures were the PsA disease activity score (40 votes) and the GRAPPA composite index (28 votes). For clinical practice, the most popular measures were an average of scores on 3 visual analog scales (45 votes) and the disease activity in PsA score (26 votes). After discussion, there was no consensus on a composite measure. The group agreed that several composite measures could be used and that future studies should allow further validation and comparison. The group unanimously agreed that remission should be the ideal target, with minimal disease activity (MDA)/low disease activity as a feasible alternative. The target should include assessment of musculoskeletal disease, skin disease, and health‐related quality of life. The group recommended a treatment target of very low disease activity (VLDA) or MDA. Conclusion Consensus was not reached on a continuous measure of disease activity. In the interim, the group recommended several composites. Consensus was reached on a treatment target of VLDA/MDA. An extensive research agenda was composed and recommends that data on all PsA clinical domains be collected in ongoing studies.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29193765</pmid><doi>10.1002/art.40391</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4756-663X</orcidid><oa>free_for_read</oa></addata></record>
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source MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection
subjects Arthritis
Arthritis, Psoriatic - diagnosis
Arthritis, Psoriatic - drug therapy
Biomedical Research
Clinical trials
Consensus
Disease control
Feasibility studies
Health care
Humans
Literature reviews
Medical personnel
Medical treatment
Musculoskeletal diseases
Outcome Assessment, Health Care - methods
Pain Measurement
Patients
Physicians
Polls & surveys
Psoriasis
Psoriatic arthritis
Quality of Life
Remission
Rheumatology
Severity of Illness Index
Skin diseases
Surveys and Questionnaires
Therapeutic applications
title Group for Research and Assessment of Psoriasis and Psoriatic Arthritis/Outcome Measures in Rheumatology Consensus‐Based Recommendations and Research Agenda for Use of Composite Measures and Treatment Targets in Psoriatic Arthritis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T04%3A26%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Group%20for%20Research%20and%20Assessment%20of%20Psoriasis%20and%20Psoriatic%20Arthritis/Outcome%20Measures%20in%20Rheumatology%20Consensus%E2%80%90Based%20Recommendations%20and%20Research%20Agenda%20for%20Use%20of%20Composite%20Measures%20and%20Treatment%20Targets%20in%20Psoriatic%20Arthritis&rft.jtitle=Arthritis%20&%20rheumatology%20(Hoboken,%20N.J.)&rft.au=Coates,%20Laura%20C.&rft.date=2018-03&rft.volume=70&rft.issue=3&rft.spage=345&rft.epage=355&rft.pages=345-355&rft.issn=2326-5191&rft.eissn=2326-5205&rft_id=info:doi/10.1002/art.40391&rft_dat=%3Cproquest_cross%3E2007916851%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2007916851&rft_id=info:pmid/29193765&rfr_iscdi=true