The beneficial effects of probiotic administration on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial
Background This study was conducted to evaluate the effects of probiotic supplementation on wound healing and metabolic status in subjects with diabetic foot ulcer (DFU). Methods This randomized, double‐blind, placebo‐controlled trial was conducted among 60 subjects (aged 40‐85 years old) with grade...
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| Veröffentlicht in: | Diabetes/metabolism research and reviews 2018-03, Vol.34 (3), p.n/a |
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| description | Background
This study was conducted to evaluate the effects of probiotic supplementation on wound healing and metabolic status in subjects with diabetic foot ulcer (DFU).
Methods
This randomized, double‐blind, placebo‐controlled trial was conducted among 60 subjects (aged 40‐85 years old) with grade 3 diabetic foot ulcer. Individuals were randomly divided into 2 groups (30 subjects each group) to receive either probiotic or placebo daily for 12 weeks.
Results
After the 12‐week intervention, compared with the placebo, probiotic supplementation led to significant reductions in ulcer length (−1.3 ± 0.9 vs. −0.8 ± 0.7 cm, P = .01), width (−1.1 ± 0.7 vs. −0.7 ± 0.7 cm, P = .02), and depth (−0.5 ± 0.3 vs. −0.3 ± 0.3 cm, P = .02). Furthermore, significant reductions in fasting plasma glucose (−29.6 ± 30.3 vs. −5.8 ± 39.8 mg/dL, P = .01), serum insulin concentrations (−4.3 ± 7.9 vs. +0.4 ± 8.5 μIU/mL, P = .03), and haemoglobin A1c (−0.6 ± 0.5 vs. −0.2 ± 0.4%, P = .003) and a significant rise in the quantitative insulin sensitivity check index (+0.01 ± 0.01 vs. −0.01 ± 0.02, P = .003) were seen following supplementation of probiotic compared with the placebo. Additionally, compared with the placebo, probiotic supplementation resulted in significant decreases in serum total cholesterol (−4.8 ± 16.1 vs. +7.0 ± 27.1 mg/dL, P = .04), high‐sensitivity C‐reactive protein (−9.0 ± 14.7 vs. −1.7 ± 8.6 mg/L, P = .02), plasma malondialdehyde (−0.8 ± 0.8 vs. −0.2 ± 0.8 μmol/L, P = .001), and significant increases in plasma nitric oxide (+6.2 ± 8.2 vs. +0.8 ± 8.0 μmol/L, P = .01) and total antioxidant capacity concentrations (+179.3 ± 97.2 vs. −85.1 ± 203.4 mmol/L, P |
| doi_str_mv | 10.1002/dmrr.2970 |
| format | Article |
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This study was conducted to evaluate the effects of probiotic supplementation on wound healing and metabolic status in subjects with diabetic foot ulcer (DFU).
Methods
This randomized, double‐blind, placebo‐controlled trial was conducted among 60 subjects (aged 40‐85 years old) with grade 3 diabetic foot ulcer. Individuals were randomly divided into 2 groups (30 subjects each group) to receive either probiotic or placebo daily for 12 weeks.
Results
After the 12‐week intervention, compared with the placebo, probiotic supplementation led to significant reductions in ulcer length (−1.3 ± 0.9 vs. −0.8 ± 0.7 cm, P = .01), width (−1.1 ± 0.7 vs. −0.7 ± 0.7 cm, P = .02), and depth (−0.5 ± 0.3 vs. −0.3 ± 0.3 cm, P = .02). Furthermore, significant reductions in fasting plasma glucose (−29.6 ± 30.3 vs. −5.8 ± 39.8 mg/dL, P = .01), serum insulin concentrations (−4.3 ± 7.9 vs. +0.4 ± 8.5 μIU/mL, P = .03), and haemoglobin A1c (−0.6 ± 0.5 vs. −0.2 ± 0.4%, P = .003) and a significant rise in the quantitative insulin sensitivity check index (+0.01 ± 0.01 vs. −0.01 ± 0.02, P = .003) were seen following supplementation of probiotic compared with the placebo. Additionally, compared with the placebo, probiotic supplementation resulted in significant decreases in serum total cholesterol (−4.8 ± 16.1 vs. +7.0 ± 27.1 mg/dL, P = .04), high‐sensitivity C‐reactive protein (−9.0 ± 14.7 vs. −1.7 ± 8.6 mg/L, P = .02), plasma malondialdehyde (−0.8 ± 0.8 vs. −0.2 ± 0.8 μmol/L, P = .001), and significant increases in plasma nitric oxide (+6.2 ± 8.2 vs. +0.8 ± 8.0 μmol/L, P = .01) and total antioxidant capacity concentrations (+179.3 ± 97.2 vs. −85.1 ± 203.4 mmol/L, P < .001).
Conclusions
Overall, probiotic supplementation for 12 weeks among subjects with diabetic foot ulcer had beneficial effects on ulcer size, glycaemic control, total cholesterol, high‐sensitivity C‐reactive protein, plasma nitric oxide, total antioxidant capacity, and malondialdehyde levels.</description><identifier>ISSN: 1520-7552</identifier><identifier>ISSN: 1520-7560</identifier><identifier>EISSN: 1520-7560</identifier><identifier>DOI: 10.1002/dmrr.2970</identifier><identifier>PMID: 29193662</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antioxidants ; Antioxidants - metabolism ; Biomarkers - metabolism ; C-Reactive Protein - metabolism ; Cholesterol ; Diabetes ; Diabetes mellitus ; diabetic foot ; Diabetic Foot - drug therapy ; Diabetic Foot - metabolism ; Diabetic Foot - pathology ; Double-Blind Method ; Double-blind studies ; Evidence-based medicine ; Feet ; Female ; Follow-Up Studies ; Foot diseases ; Hemoglobin ; Humans ; Insulin ; Insulin Resistance ; Leg ulcers ; Male ; Malondialdehyde ; metabolic status ; Metabolism ; Middle Aged ; Nitric oxide ; Oxidative Stress - drug effects ; probiotic administration ; Probiotics ; Probiotics - administration & dosage ; Prognosis ; Supplements ; Wound healing ; Wound Healing - drug effects</subject><ispartof>Diabetes/metabolism research and reviews, 2018-03, Vol.34 (3), p.n/a</ispartof><rights>Copyright © 2017 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3880-cf47474cef0aa6f4bb7796f07fac5f78196ee6c0efcf8d18151b9edc796edb1b3</citedby><cites>FETCH-LOGICAL-c3880-cf47474cef0aa6f4bb7796f07fac5f78196ee6c0efcf8d18151b9edc796edb1b3</cites><orcidid>0000-0001-5265-4792</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdmrr.2970$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdmrr.2970$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29193662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohseni, Sima</creatorcontrib><creatorcontrib>Bayani, Masomeh</creatorcontrib><creatorcontrib>Bahmani, Fereshteh</creatorcontrib><creatorcontrib>Tajabadi‐Ebrahimi, Maryam</creatorcontrib><creatorcontrib>Bayani, Mohammad Ali</creatorcontrib><creatorcontrib>Jafari, Parvaneh</creatorcontrib><creatorcontrib>Asemi, Zatollah</creatorcontrib><title>The beneficial effects of probiotic administration on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial</title><title>Diabetes/metabolism research and reviews</title><addtitle>Diabetes Metab Res Rev</addtitle><description>Background
This study was conducted to evaluate the effects of probiotic supplementation on wound healing and metabolic status in subjects with diabetic foot ulcer (DFU).
Methods
This randomized, double‐blind, placebo‐controlled trial was conducted among 60 subjects (aged 40‐85 years old) with grade 3 diabetic foot ulcer. Individuals were randomly divided into 2 groups (30 subjects each group) to receive either probiotic or placebo daily for 12 weeks.
Results
After the 12‐week intervention, compared with the placebo, probiotic supplementation led to significant reductions in ulcer length (−1.3 ± 0.9 vs. −0.8 ± 0.7 cm, P = .01), width (−1.1 ± 0.7 vs. −0.7 ± 0.7 cm, P = .02), and depth (−0.5 ± 0.3 vs. −0.3 ± 0.3 cm, P = .02). Furthermore, significant reductions in fasting plasma glucose (−29.6 ± 30.3 vs. −5.8 ± 39.8 mg/dL, P = .01), serum insulin concentrations (−4.3 ± 7.9 vs. +0.4 ± 8.5 μIU/mL, P = .03), and haemoglobin A1c (−0.6 ± 0.5 vs. −0.2 ± 0.4%, P = .003) and a significant rise in the quantitative insulin sensitivity check index (+0.01 ± 0.01 vs. −0.01 ± 0.02, P = .003) were seen following supplementation of probiotic compared with the placebo. Additionally, compared with the placebo, probiotic supplementation resulted in significant decreases in serum total cholesterol (−4.8 ± 16.1 vs. +7.0 ± 27.1 mg/dL, P = .04), high‐sensitivity C‐reactive protein (−9.0 ± 14.7 vs. −1.7 ± 8.6 mg/L, P = .02), plasma malondialdehyde (−0.8 ± 0.8 vs. −0.2 ± 0.8 μmol/L, P = .001), and significant increases in plasma nitric oxide (+6.2 ± 8.2 vs. +0.8 ± 8.0 μmol/L, P = .01) and total antioxidant capacity concentrations (+179.3 ± 97.2 vs. −85.1 ± 203.4 mmol/L, P < .001).
Conclusions
Overall, probiotic supplementation for 12 weeks among subjects with diabetic foot ulcer had beneficial effects on ulcer size, glycaemic control, total cholesterol, high‐sensitivity C‐reactive protein, plasma nitric oxide, total antioxidant capacity, and malondialdehyde levels.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Biomarkers - metabolism</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>diabetic foot</subject><subject>Diabetic Foot - drug therapy</subject><subject>Diabetic Foot - metabolism</subject><subject>Diabetic Foot - pathology</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Evidence-based medicine</subject><subject>Feet</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Foot diseases</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Leg ulcers</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>metabolic status</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Nitric oxide</subject><subject>Oxidative Stress - drug effects</subject><subject>probiotic administration</subject><subject>Probiotics</subject><subject>Probiotics - administration & dosage</subject><subject>Prognosis</subject><subject>Supplements</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><issn>1520-7552</issn><issn>1520-7560</issn><issn>1520-7560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd1qFDEUx4NYbK1e-AIS8EbBbZPZmcxM70r9aKEilHod8nHipmSSNcmw1CsfwbfxfXwSz3ZrLwRJICfhlx-H8yfkBWdHnLHm2E45HzVjzx6RA941bNF3gj1-qLtmnzwt5YYxtmxF-4TsNyMfl0I0B-TX9QqohgjOG68CBefA1EKTo-uctE_VG6rs5KMvNavqU6S4N2mOlq5ABR-_UoX1BFXpFJAuVdW5UB_pGnmIaNv4uqLWKw1bnUup0jkYyCf0lGb8nSb_HexbatOsA_z-8VOjF-_roAzohA8mxZpTCGBpzdjoM7LnVCjw_P48JF8-vL8-O19cfv54cXZ6uTDLYWAL49oelwHHlBKu1brvR-FY75TpXD_wUQAIw8AZN1g-8I7rEaxBCKzmenlIXu-8OI1vM5QqJ18MhKAipLlIPvZctDhLgeirf9CbNOeI3cmGcd60XcMHpN7sKJNTKRmcXGc_qXwrOZPbNOU2TblNE9mX98ZZT2AfyL_xIXC8AzY-wO3_TfLdp6urO-UfbBuwlg</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Mohseni, Sima</creator><creator>Bayani, Masomeh</creator><creator>Bahmani, Fereshteh</creator><creator>Tajabadi‐Ebrahimi, Maryam</creator><creator>Bayani, Mohammad Ali</creator><creator>Jafari, Parvaneh</creator><creator>Asemi, Zatollah</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5265-4792</orcidid></search><sort><creationdate>201803</creationdate><title>The beneficial effects of probiotic administration on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial</title><author>Mohseni, Sima ; Bayani, Masomeh ; Bahmani, Fereshteh ; Tajabadi‐Ebrahimi, Maryam ; Bayani, Mohammad Ali ; Jafari, Parvaneh ; Asemi, Zatollah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3880-cf47474cef0aa6f4bb7796f07fac5f78196ee6c0efcf8d18151b9edc796edb1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Biomarkers - metabolism</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>diabetic foot</topic><topic>Diabetic Foot - drug therapy</topic><topic>Diabetic Foot - metabolism</topic><topic>Diabetic Foot - pathology</topic><topic>Double-Blind Method</topic><topic>Double-blind studies</topic><topic>Evidence-based medicine</topic><topic>Feet</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Foot diseases</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>Leg ulcers</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>metabolic status</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Nitric oxide</topic><topic>Oxidative Stress - drug effects</topic><topic>probiotic administration</topic><topic>Probiotics</topic><topic>Probiotics - administration & dosage</topic><topic>Prognosis</topic><topic>Supplements</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohseni, Sima</creatorcontrib><creatorcontrib>Bayani, Masomeh</creatorcontrib><creatorcontrib>Bahmani, Fereshteh</creatorcontrib><creatorcontrib>Tajabadi‐Ebrahimi, Maryam</creatorcontrib><creatorcontrib>Bayani, Mohammad Ali</creatorcontrib><creatorcontrib>Jafari, Parvaneh</creatorcontrib><creatorcontrib>Asemi, Zatollah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes/metabolism research and reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohseni, Sima</au><au>Bayani, Masomeh</au><au>Bahmani, Fereshteh</au><au>Tajabadi‐Ebrahimi, Maryam</au><au>Bayani, Mohammad Ali</au><au>Jafari, Parvaneh</au><au>Asemi, Zatollah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The beneficial effects of probiotic administration on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial</atitle><jtitle>Diabetes/metabolism research and reviews</jtitle><addtitle>Diabetes Metab Res Rev</addtitle><date>2018-03</date><risdate>2018</risdate><volume>34</volume><issue>3</issue><epage>n/a</epage><issn>1520-7552</issn><issn>1520-7560</issn><eissn>1520-7560</eissn><abstract>Background
This study was conducted to evaluate the effects of probiotic supplementation on wound healing and metabolic status in subjects with diabetic foot ulcer (DFU).
Methods
This randomized, double‐blind, placebo‐controlled trial was conducted among 60 subjects (aged 40‐85 years old) with grade 3 diabetic foot ulcer. Individuals were randomly divided into 2 groups (30 subjects each group) to receive either probiotic or placebo daily for 12 weeks.
Results
After the 12‐week intervention, compared with the placebo, probiotic supplementation led to significant reductions in ulcer length (−1.3 ± 0.9 vs. −0.8 ± 0.7 cm, P = .01), width (−1.1 ± 0.7 vs. −0.7 ± 0.7 cm, P = .02), and depth (−0.5 ± 0.3 vs. −0.3 ± 0.3 cm, P = .02). Furthermore, significant reductions in fasting plasma glucose (−29.6 ± 30.3 vs. −5.8 ± 39.8 mg/dL, P = .01), serum insulin concentrations (−4.3 ± 7.9 vs. +0.4 ± 8.5 μIU/mL, P = .03), and haemoglobin A1c (−0.6 ± 0.5 vs. −0.2 ± 0.4%, P = .003) and a significant rise in the quantitative insulin sensitivity check index (+0.01 ± 0.01 vs. −0.01 ± 0.02, P = .003) were seen following supplementation of probiotic compared with the placebo. Additionally, compared with the placebo, probiotic supplementation resulted in significant decreases in serum total cholesterol (−4.8 ± 16.1 vs. +7.0 ± 27.1 mg/dL, P = .04), high‐sensitivity C‐reactive protein (−9.0 ± 14.7 vs. −1.7 ± 8.6 mg/L, P = .02), plasma malondialdehyde (−0.8 ± 0.8 vs. −0.2 ± 0.8 μmol/L, P = .001), and significant increases in plasma nitric oxide (+6.2 ± 8.2 vs. +0.8 ± 8.0 μmol/L, P = .01) and total antioxidant capacity concentrations (+179.3 ± 97.2 vs. −85.1 ± 203.4 mmol/L, P < .001).
Conclusions
Overall, probiotic supplementation for 12 weeks among subjects with diabetic foot ulcer had beneficial effects on ulcer size, glycaemic control, total cholesterol, high‐sensitivity C‐reactive protein, plasma nitric oxide, total antioxidant capacity, and malondialdehyde levels.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29193662</pmid><doi>10.1002/dmrr.2970</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5265-4792</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antioxidants Antioxidants - metabolism Biomarkers - metabolism C-Reactive Protein - metabolism Cholesterol Diabetes Diabetes mellitus diabetic foot Diabetic Foot - drug therapy Diabetic Foot - metabolism Diabetic Foot - pathology Double-Blind Method Double-blind studies Evidence-based medicine Feet Female Follow-Up Studies Foot diseases Hemoglobin Humans Insulin Insulin Resistance Leg ulcers Male Malondialdehyde metabolic status Metabolism Middle Aged Nitric oxide Oxidative Stress - drug effects probiotic administration Probiotics Probiotics - administration & dosage Prognosis Supplements Wound healing Wound Healing - drug effects |
| title | The beneficial effects of probiotic administration on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial |
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