9.4T and 17.6T MRI of Retinoblastoma: Ex Vivo evaluation of microstructural anatomy and disease extent compared with histopathology
Background Retinoblastoma is the most common intraocular tumor in childhood with a good prognosis in terms of mortality, but detailed information about tumor morphology and disease extent in retinoblastoma is important for treatment decision making. Purpose To demonstrate ultrahigh‐field MRI tumor m...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2018-06, Vol.47 (6), p.1487-1497 |
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| creator | Jong, Marcus C. Graaf, Pim Pouwels, Petra J.W. Beenakker, Jan‐Willem Jansen, Robin W. Geurts, Jeroen J.G. Moll, Annette C. Castelijns, Jonas A. Valk, Paul Weerd, Louise |
| description | Background
Retinoblastoma is the most common intraocular tumor in childhood with a good prognosis in terms of mortality, but detailed information about tumor morphology and disease extent in retinoblastoma is important for treatment decision making.
Purpose
To demonstrate ultrahigh‐field MRI tumor morphology and tumor extent in retinoblastoma correlating with in and ex vivo images with histopathology.
Study Type
Prospective case series.
Population
Six retinoblastoma patients (median age 5.5 months, range 2–14) were prospectively included in this study. Median time between diagnosis and enucleation was 8 days (range 7–19).
Field Strength/Sequence
In vivo pre‐enucleation at 1.5T MRI with a circular surface coil. Ex vivo imaging (FLASH T1‐weighted and RARE T2‐weighted) was performed at field strengths of 9.4T and 17.6T.
Assessment
After ex vivo imaging, the eyes were histopathologically analyzed and morphologically matched with MRI findings by three authors (two with respectively 14 and 4 years of experience in ocular MRI and one with 16 years of experience in ophthalmopathology).
Results
Small submillimeter morphological aspects of intraocular retinoblastoma were successfully depicted with higher‐resolution MRI and matched with histopathology images. With ex vivo MRI a small subretinal tumor seed (300 μm) adjacent to the choroid was morphologically matched with histopathology. Also, a characteristic geographical pattern of vital tumor tissue (400 μm) surrounding a central vessel interspersed with necrotic areas correlated with histopathology images. Tumor invasion into the optic nerve showed a higher signal intensity on T1‐weighted higher‐resolution MRI.
Data Conclusion
Higher‐resolution MRI allows for small morphological aspects of intraocular retinoblastoma and extraocular disease extent not visible on currently used clinical in vivo MRI to be depicted.
Level of Evidence: 4
Technical Efficacy: Stage 2
J. Magn. Reson. Imaging 2018;47:1487–1497. |
| doi_str_mv | 10.1002/jmri.25913 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1971643425</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1971643425</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3573-34466e41c093bfea30b2ebab52fe7a14cdd6aba7e50cba9e981d82159d8f7ae83</originalsourceid><addsrcrecordid>eNp90T9v1DAYx3ELFdFSWHgBlSUWhJTDf5OYrapKKSpCqg5W60nypOdTEh-20_bmvnF8vcLA0MkePvrK8o-Qd5wtOGPi03oMbiG04fIFOeJaiELoujzId6ZlwWtWHZLXMa4ZY8Yo_YocCsON1KU5Ig9moZYUpo7yalEu6ffrS-p7eo3JTb4ZICY_wmd6fk9_uVtP8RaGGZLz006Nrg0-pjC3aQ4w5Axkvn3MdS4iRKR4n3BKtPXjBgJ29M6lFV253N1AWvnB32zfkJc9DBHfPp3H5OeX8-XZ1-Lqx8Xl2elV0UpdyUIqVZaoeMuMbHoEyRqBDTRa9FgBV23XldBAhZq1DRg0Ne9qwbXp6r4CrOUx-bDvboL_PWNMdnSxxWGACf0cLTcVL5VUQmf6_j-69nOY8uusYKpSohRcZfVxr3bfEAP2dhPcCGFrObO7aexuGvs4TcYnT8m5GbH7R_9ukQHfgzs34PaZlP2WV9pH_wCNHJpE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2047426214</pqid></control><display><type>article</type><title>9.4T and 17.6T MRI of Retinoblastoma: Ex Vivo evaluation of microstructural anatomy and disease extent compared with histopathology</title><source>Wiley Free Content</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Jong, Marcus C. ; Graaf, Pim ; Pouwels, Petra J.W. ; Beenakker, Jan‐Willem ; Jansen, Robin W. ; Geurts, Jeroen J.G. ; Moll, Annette C. ; Castelijns, Jonas A. ; Valk, Paul ; Weerd, Louise</creator><creatorcontrib>Jong, Marcus C. ; Graaf, Pim ; Pouwels, Petra J.W. ; Beenakker, Jan‐Willem ; Jansen, Robin W. ; Geurts, Jeroen J.G. ; Moll, Annette C. ; Castelijns, Jonas A. ; Valk, Paul ; Weerd, Louise</creatorcontrib><description>Background
Retinoblastoma is the most common intraocular tumor in childhood with a good prognosis in terms of mortality, but detailed information about tumor morphology and disease extent in retinoblastoma is important for treatment decision making.
Purpose
To demonstrate ultrahigh‐field MRI tumor morphology and tumor extent in retinoblastoma correlating with in and ex vivo images with histopathology.
Study Type
Prospective case series.
Population
Six retinoblastoma patients (median age 5.5 months, range 2–14) were prospectively included in this study. Median time between diagnosis and enucleation was 8 days (range 7–19).
Field Strength/Sequence
In vivo pre‐enucleation at 1.5T MRI with a circular surface coil. Ex vivo imaging (FLASH T1‐weighted and RARE T2‐weighted) was performed at field strengths of 9.4T and 17.6T.
Assessment
After ex vivo imaging, the eyes were histopathologically analyzed and morphologically matched with MRI findings by three authors (two with respectively 14 and 4 years of experience in ocular MRI and one with 16 years of experience in ophthalmopathology).
Results
Small submillimeter morphological aspects of intraocular retinoblastoma were successfully depicted with higher‐resolution MRI and matched with histopathology images. With ex vivo MRI a small subretinal tumor seed (300 μm) adjacent to the choroid was morphologically matched with histopathology. Also, a characteristic geographical pattern of vital tumor tissue (400 μm) surrounding a central vessel interspersed with necrotic areas correlated with histopathology images. Tumor invasion into the optic nerve showed a higher signal intensity on T1‐weighted higher‐resolution MRI.
Data Conclusion
Higher‐resolution MRI allows for small morphological aspects of intraocular retinoblastoma and extraocular disease extent not visible on currently used clinical in vivo MRI to be depicted.
Level of Evidence: 4
Technical Efficacy: Stage 2
J. Magn. Reson. Imaging 2018;47:1487–1497.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.25913</identifier><identifier>PMID: 29193569</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>17.6 Tesla ; 9.4 Tesla ; Cancer ; Children ; Decision making ; diagnostic accuracy ; Enucleation ; Eye (anatomy) ; Field strength ; Histopathology ; Magnetic resonance imaging ; Medical imaging ; Medical treatment ; Morphology ; MR microscopy ; Optic nerve ; Retina ; Retinoblastoma ; tumor seeding ; Tumors</subject><ispartof>Journal of magnetic resonance imaging, 2018-06, Vol.47 (6), p.1487-1497</ispartof><rights>2017 International Society for Magnetic Resonance in Medicine</rights><rights>2017 International Society for Magnetic Resonance in Medicine.</rights><rights>2018 International Society for Magnetic Resonance in Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3573-34466e41c093bfea30b2ebab52fe7a14cdd6aba7e50cba9e981d82159d8f7ae83</citedby><cites>FETCH-LOGICAL-c3573-34466e41c093bfea30b2ebab52fe7a14cdd6aba7e50cba9e981d82159d8f7ae83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.25913$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.25913$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29193569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jong, Marcus C.</creatorcontrib><creatorcontrib>Graaf, Pim</creatorcontrib><creatorcontrib>Pouwels, Petra J.W.</creatorcontrib><creatorcontrib>Beenakker, Jan‐Willem</creatorcontrib><creatorcontrib>Jansen, Robin W.</creatorcontrib><creatorcontrib>Geurts, Jeroen J.G.</creatorcontrib><creatorcontrib>Moll, Annette C.</creatorcontrib><creatorcontrib>Castelijns, Jonas A.</creatorcontrib><creatorcontrib>Valk, Paul</creatorcontrib><creatorcontrib>Weerd, Louise</creatorcontrib><title>9.4T and 17.6T MRI of Retinoblastoma: Ex Vivo evaluation of microstructural anatomy and disease extent compared with histopathology</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>Background
Retinoblastoma is the most common intraocular tumor in childhood with a good prognosis in terms of mortality, but detailed information about tumor morphology and disease extent in retinoblastoma is important for treatment decision making.
Purpose
To demonstrate ultrahigh‐field MRI tumor morphology and tumor extent in retinoblastoma correlating with in and ex vivo images with histopathology.
Study Type
Prospective case series.
Population
Six retinoblastoma patients (median age 5.5 months, range 2–14) were prospectively included in this study. Median time between diagnosis and enucleation was 8 days (range 7–19).
Field Strength/Sequence
In vivo pre‐enucleation at 1.5T MRI with a circular surface coil. Ex vivo imaging (FLASH T1‐weighted and RARE T2‐weighted) was performed at field strengths of 9.4T and 17.6T.
Assessment
After ex vivo imaging, the eyes were histopathologically analyzed and morphologically matched with MRI findings by three authors (two with respectively 14 and 4 years of experience in ocular MRI and one with 16 years of experience in ophthalmopathology).
Results
Small submillimeter morphological aspects of intraocular retinoblastoma were successfully depicted with higher‐resolution MRI and matched with histopathology images. With ex vivo MRI a small subretinal tumor seed (300 μm) adjacent to the choroid was morphologically matched with histopathology. Also, a characteristic geographical pattern of vital tumor tissue (400 μm) surrounding a central vessel interspersed with necrotic areas correlated with histopathology images. Tumor invasion into the optic nerve showed a higher signal intensity on T1‐weighted higher‐resolution MRI.
Data Conclusion
Higher‐resolution MRI allows for small morphological aspects of intraocular retinoblastoma and extraocular disease extent not visible on currently used clinical in vivo MRI to be depicted.
Level of Evidence: 4
Technical Efficacy: Stage 2
J. Magn. Reson. Imaging 2018;47:1487–1497.</description><subject>17.6 Tesla</subject><subject>9.4 Tesla</subject><subject>Cancer</subject><subject>Children</subject><subject>Decision making</subject><subject>diagnostic accuracy</subject><subject>Enucleation</subject><subject>Eye (anatomy)</subject><subject>Field strength</subject><subject>Histopathology</subject><subject>Magnetic resonance imaging</subject><subject>Medical imaging</subject><subject>Medical treatment</subject><subject>Morphology</subject><subject>MR microscopy</subject><subject>Optic nerve</subject><subject>Retina</subject><subject>Retinoblastoma</subject><subject>tumor seeding</subject><subject>Tumors</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp90T9v1DAYx3ELFdFSWHgBlSUWhJTDf5OYrapKKSpCqg5W60nypOdTEh-20_bmvnF8vcLA0MkePvrK8o-Qd5wtOGPi03oMbiG04fIFOeJaiELoujzId6ZlwWtWHZLXMa4ZY8Yo_YocCsON1KU5Ig9moZYUpo7yalEu6ffrS-p7eo3JTb4ZICY_wmd6fk9_uVtP8RaGGZLz006Nrg0-pjC3aQ4w5Axkvn3MdS4iRKR4n3BKtPXjBgJ29M6lFV253N1AWvnB32zfkJc9DBHfPp3H5OeX8-XZ1-Lqx8Xl2elV0UpdyUIqVZaoeMuMbHoEyRqBDTRa9FgBV23XldBAhZq1DRg0Ne9qwbXp6r4CrOUx-bDvboL_PWNMdnSxxWGACf0cLTcVL5VUQmf6_j-69nOY8uusYKpSohRcZfVxr3bfEAP2dhPcCGFrObO7aexuGvs4TcYnT8m5GbH7R_9ukQHfgzs34PaZlP2WV9pH_wCNHJpE</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Jong, Marcus C.</creator><creator>Graaf, Pim</creator><creator>Pouwels, Petra J.W.</creator><creator>Beenakker, Jan‐Willem</creator><creator>Jansen, Robin W.</creator><creator>Geurts, Jeroen J.G.</creator><creator>Moll, Annette C.</creator><creator>Castelijns, Jonas A.</creator><creator>Valk, Paul</creator><creator>Weerd, Louise</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201806</creationdate><title>9.4T and 17.6T MRI of Retinoblastoma: Ex Vivo evaluation of microstructural anatomy and disease extent compared with histopathology</title><author>Jong, Marcus C. ; Graaf, Pim ; Pouwels, Petra J.W. ; Beenakker, Jan‐Willem ; Jansen, Robin W. ; Geurts, Jeroen J.G. ; Moll, Annette C. ; Castelijns, Jonas A. ; Valk, Paul ; Weerd, Louise</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3573-34466e41c093bfea30b2ebab52fe7a14cdd6aba7e50cba9e981d82159d8f7ae83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>17.6 Tesla</topic><topic>9.4 Tesla</topic><topic>Cancer</topic><topic>Children</topic><topic>Decision making</topic><topic>diagnostic accuracy</topic><topic>Enucleation</topic><topic>Eye (anatomy)</topic><topic>Field strength</topic><topic>Histopathology</topic><topic>Magnetic resonance imaging</topic><topic>Medical imaging</topic><topic>Medical treatment</topic><topic>Morphology</topic><topic>MR microscopy</topic><topic>Optic nerve</topic><topic>Retina</topic><topic>Retinoblastoma</topic><topic>tumor seeding</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jong, Marcus C.</creatorcontrib><creatorcontrib>Graaf, Pim</creatorcontrib><creatorcontrib>Pouwels, Petra J.W.</creatorcontrib><creatorcontrib>Beenakker, Jan‐Willem</creatorcontrib><creatorcontrib>Jansen, Robin W.</creatorcontrib><creatorcontrib>Geurts, Jeroen J.G.</creatorcontrib><creatorcontrib>Moll, Annette C.</creatorcontrib><creatorcontrib>Castelijns, Jonas A.</creatorcontrib><creatorcontrib>Valk, Paul</creatorcontrib><creatorcontrib>Weerd, Louise</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jong, Marcus C.</au><au>Graaf, Pim</au><au>Pouwels, Petra J.W.</au><au>Beenakker, Jan‐Willem</au><au>Jansen, Robin W.</au><au>Geurts, Jeroen J.G.</au><au>Moll, Annette C.</au><au>Castelijns, Jonas A.</au><au>Valk, Paul</au><au>Weerd, Louise</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>9.4T and 17.6T MRI of Retinoblastoma: Ex Vivo evaluation of microstructural anatomy and disease extent compared with histopathology</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2018-06</date><risdate>2018</risdate><volume>47</volume><issue>6</issue><spage>1487</spage><epage>1497</epage><pages>1487-1497</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Background
Retinoblastoma is the most common intraocular tumor in childhood with a good prognosis in terms of mortality, but detailed information about tumor morphology and disease extent in retinoblastoma is important for treatment decision making.
Purpose
To demonstrate ultrahigh‐field MRI tumor morphology and tumor extent in retinoblastoma correlating with in and ex vivo images with histopathology.
Study Type
Prospective case series.
Population
Six retinoblastoma patients (median age 5.5 months, range 2–14) were prospectively included in this study. Median time between diagnosis and enucleation was 8 days (range 7–19).
Field Strength/Sequence
In vivo pre‐enucleation at 1.5T MRI with a circular surface coil. Ex vivo imaging (FLASH T1‐weighted and RARE T2‐weighted) was performed at field strengths of 9.4T and 17.6T.
Assessment
After ex vivo imaging, the eyes were histopathologically analyzed and morphologically matched with MRI findings by three authors (two with respectively 14 and 4 years of experience in ocular MRI and one with 16 years of experience in ophthalmopathology).
Results
Small submillimeter morphological aspects of intraocular retinoblastoma were successfully depicted with higher‐resolution MRI and matched with histopathology images. With ex vivo MRI a small subretinal tumor seed (300 μm) adjacent to the choroid was morphologically matched with histopathology. Also, a characteristic geographical pattern of vital tumor tissue (400 μm) surrounding a central vessel interspersed with necrotic areas correlated with histopathology images. Tumor invasion into the optic nerve showed a higher signal intensity on T1‐weighted higher‐resolution MRI.
Data Conclusion
Higher‐resolution MRI allows for small morphological aspects of intraocular retinoblastoma and extraocular disease extent not visible on currently used clinical in vivo MRI to be depicted.
Level of Evidence: 4
Technical Efficacy: Stage 2
J. Magn. Reson. Imaging 2018;47:1487–1497.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29193569</pmid><doi>10.1002/jmri.25913</doi><tpages>11</tpages></addata></record> |
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| source | Wiley Free Content; Wiley Online Library Journals Frontfile Complete |
| subjects | 17.6 Tesla 9.4 Tesla Cancer Children Decision making diagnostic accuracy Enucleation Eye (anatomy) Field strength Histopathology Magnetic resonance imaging Medical imaging Medical treatment Morphology MR microscopy Optic nerve Retina Retinoblastoma tumor seeding Tumors |
| title | 9.4T and 17.6T MRI of Retinoblastoma: Ex Vivo evaluation of microstructural anatomy and disease extent compared with histopathology |
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